{"id":7270,"date":"2021-12-16T07:20:08","date_gmt":"2021-12-16T12:20:08","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/enfuvirtid-enfuvirtid-acetate-cas-159519-65-0-pro-anti-hiv\/"},"modified":"2021-12-16T07:20:08","modified_gmt":"2021-12-16T12:20:08","slug":"enfuvirtid-enfuvirtid-acetate-cas-159519-65-0-pro-anti-hiv","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/enfuvirtid-enfuvirtid-acetate-cas-159519-65-0-pro-anti-hiv\/","title":{"rendered":"Enfuvirtid\/Enfuvirtid Acetate CAS 159519-65-0 Pro Anti HIV"},"content":{"rendered":"

Enfuvirtid\/Enfuvirtid Acetate CAS 159519-65-0 Pro Anti HIV<\/strong><\/h2>\n

N\u00e1zev produktu: Enfuvirtide
\nSekvence: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys< &>-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\nSynonyma: Enfuvirtid; T-2;Enfuvirtid acet\u00e1t (T-20);ENFUVIRTID(T-20) 98+%;Enfurvitid(T-20);Pentafusid;Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH{2};Enfuvirtide;Aids059486
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491,92
\nEINECS: 641-385-0 Kategorie produkt\u016f : proteiny;Peptid
\nMol File: 159519-65-0.mol<\/p>\n

Je to syntetick\u00fd peptidov\u00fd inhibitor f\u00faze HIV, kter\u00fd se m\u016f\u017ee v\u00e1zat na glykoprotein virov\u00e9ho obalu a zabr\u00e1nit konforma\u010dn\u00edm zm\u011bn\u00e1m nezbytn\u00fdm pro virus f\u00fazovat s bun\u011b\u010dnou membr\u00e1nou a t\u00edm inhibovat replikaci HIV-1. Peptid Enfevir je odvozen z p\u0159irozen\u011b se vyskytuj\u00edc\u00ed aminokyselinov\u00e9 sekvence v HR2 dom\u00e9n\u011b gp41. Simulac\u00ed aktivity dom\u00e9ny HR2 a kompetitivn\u00ed vazbou na dom\u00e9nu HR1 gp41 peptid Enfevir zabra\u0148uje interakci mezi HR1 a HR2 a zm\u011bn\u00e1m v konfiguraci Gp41, \u010d\u00edm\u017e zabra\u0148uje f\u00fazi viru s hostitelsk\u00fdmi bu\u0148kami.<\/p>\n

Enfuvirtid je prvn\u00ed z nov\u00e9 t\u0159\u00eddy HIV terapeutik, kter\u00e1 interferuj\u00ed se vstupem HIV-1 inhibic\u00ed f\u00faze virov\u00fdch a bun\u011b\u010dn\u00fdch membr\u00e1n. V\u00e1\u017ee se na prvn\u00ed sedmi\u010dkovou repetici (HR1) v ghe gp41 podjednotce glykoproteinu virov\u00e9ho obalu a zabra\u0148uje konforma\u010dn\u00edm zm\u011bn\u00e1m pot\u0159ebn\u00fdm pro f\u00fazi s bun\u011b\u010dn\u00fdmi membr\u00e1nami, \u010d\u00edm\u017e p\u0159edstavuje nov\u00fd mechanismus. Je to siln\u00fd inhibitor t\u00e9to vazby s IC50 v laboratorn\u00edch a prim\u00e1rn\u00edch izol\u00e1tech (HIV-1 klade A\u2013G) v rozmez\u00ed od 4 do 280 nM (18\u20131260 ng\/ml), ale nem\u00e1 prakticky \u017e\u00e1dnou aktivitu proti HIV-2. D\u00edky sv\u00e9mu jedine\u010dn\u00e9mu mechanismu nevykazuje zk\u0159\u00ed\u017eenou rezistenci v\u016f\u010di NRTI, NNRTI a PI. P\u0159ipravuje se chemickou synt\u00e9zou za pou\u017eit\u00ed kombinace krok\u016f v roztoku a na pevn\u00e9 f\u00e1zi. Kroky na pevn\u00e9 f\u00e1zi vyu\u017e\u00edvaj\u00ed ochranu fmoc a na kyselinu citlivou 2-chlortritylchloridovou prysky\u0159ici k v\u00fdrob\u011b peptid\u016f o d\u00e9lk\u00e1ch v rozmez\u00ed od dev\u00edti do \u0161estn\u00e1cti aminokyselin. <\/p>\n

Enfuvirtid\/ Enfuvirtid Acetate CAS 159519-65-0 Chemick\u00e9 vlastnosti<\/strong>
\nskladovac\u00ed tepl. -20\u00b0C
\npr\u00e1\u0161kov\u00e1 forma
\nbarva b\u00edl\u00e1 a\u017e t\u00e9m\u011b\u0159 b\u00edl\u00e1<\/p>\n

Pou\u017eit\u00ed enfuvirtidu\/enfuvirtid acet\u00e1tu CAS 159519-65-0<\/strong>
\nPou\u017e\u00edv\u00e1 se v kombinaci s l\u00e9ky s reverzn\u00ed transkript\u00e1zou pro \u010dlov\u011bka infekce virem imunodeficience (HIV).<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Enfuvirtide
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491,92
\nEINECS: 641-385-0
\nMol Soubor: 159519-65-0.mol<\/p>\n","protected":false},"featured_media":2118,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[515],"product_tag":[2505],"class_list":{"0":"post-7270","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-jine-peptidy","7":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-cs","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/7270","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=7270"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2118"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=7270"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=7270"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=7270"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=7270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}