{"id":7293,"date":"2021-12-16T07:20:57","date_gmt":"2021-12-16T12:20:57","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/carperitide-acetate-anp-1-28-human-cas-89213-87-6-pro-lecbu-mestnaveho-srdecniho-selhani\/"},"modified":"2021-12-16T07:20:57","modified_gmt":"2021-12-16T12:20:57","slug":"carperitide-acetate-anp-1-28-human-cas-89213-87-6-pro-lecbu-mestnaveho-srdecniho-selhani","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/carperitide-acetate-anp-1-28-human-cas-89213-87-6-pro-lecbu-mestnaveho-srdecniho-selhani\/","title":{"rendered":"Carperitide Acetate\/ANP 1-28, HUMAN CAS 89213-87-6 Pro l\u00e9\u010dbu m\u011bstnav\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed"},"content":{"rendered":"

Carperitide Acetate\/ANP 1-28, HUMAN CAS 89213-87-6 Pro l\u00e9\u010dbu m\u011bstnav\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed<\/strong><\/h2>\n

N\u00e1zev produktu: Carperitide Acetate\/ANP 1-28, HUMAN
\nSekvence\uff1a H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg- Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH\uff0c(disulfidov\u00fd m\u016fstek: Cys-Cys)
\nSynonyma: S\u00cd\u0147OV\u00dd NATRIURETICK\u00dd PEPTID \u010cLOV\u011aK;SER- LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET: O-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER- PHE-ARG-TYR[SLRRSSCFGGR-MET: O-DRIGAQSGLGCNSFRY]DISULFIDE BRIDGE CYS7-CYS23.;Acet\u00e1t karperitidu, karperitida;Atri\u00e1ln\u00ed natriuretick\u00fd peptid (1-28) (\u010dlov\u011bk) (trifluoracet\u00e1tov\u00e1 s\u016fl);ahANF, Carperitide Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe- Arg-Tyr-OH;Atri\u00e1ln\u00ed natriuretick\u00fd peptid-28 (huMan) (9CI);Atri\u00e1ln\u00ed natriuretick\u00fd faktor (1-28) (huMan) ahANF, Carperitid
\nCAS: 89213-87-6
\nMF: C127H203N45O39S3< MW: 3080,44
\nEINECS: 686-482-9
\nKategorie produkt\u016f: peptid
\nMol File: 89213-87-6.mol<\/p>\n

Karperitid je polypeptid s 28 aminokyselinami se stabiln\u00ed sekund\u00e1rn\u00ed struktura a je cir kultiva\u010dn\u00ed hormon, kter\u00fd p\u016fsob\u00ed jako vazodilat\u00e1tor a diuretikum. V klinick\u00e9 praxi je vazodilatace vyvolan\u00e1 karperitidem jako hlavn\u00ed slo\u017ekou zp\u016fsobena vazbou na receptory ANP (atri\u00e1ln\u00ed natriuretick\u00fd polypeptid) v hladk\u00e9m svalstvu c\u00e9v, \u010deho\u017e je dosa\u017eeno zv\u00fd\u0161en\u00edm aktivity guanyl\u00e1tcykl\u00e1zy, co\u017e nazna\u010duje sn\u00ed\u017een\u00ed srde\u010dn\u00edho pre a afterloadu. <\/p>\n

Karperitid je \u03b1-lidsk\u00fd atri\u00e1ln\u00ed natriuretick\u00fd peptid (\u03b1-hANP) vyroben\u00fd rekombinantn\u00ed technologi\u00ed. Byl zaveden v Japonsku jako l\u00e9\u010dba akutn\u00edho m\u011bstnav\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed (CHF). U ps\u016f s CHF karperitida v\u00fdznamn\u011b sn\u00ed\u017eila zv\u00fd\u0161en\u00fd enddiastolick\u00fd tlak lev\u00e9 komory a index spot\u0159eby kysl\u00edku myokardem (systolick\u00fd krevn\u00ed tlak x srde\u010dn\u00ed frekvence). V klinick\u00e9 studii byla karperitida \u00fa\u010dinn\u00e1 ve zlep\u0161en\u00ed hemodynamiky a symptom\u016f u 60 % pacient\u016f s akutn\u00edm CHF. Bylo hl\u00e1\u0161eno, \u017ee karperitid je dob\u0159e sn\u00e1\u0161en bez v\u00fdznamn\u00fdch klinicky ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f. P\u0159\u00edzniv\u00fd \u00fa\u010dinek na hemodynamiku byl pops\u00e1n u pacient\u016f s chronick\u00fdm srde\u010dn\u00edm selh\u00e1n\u00edm. Karperitid je tak\u00e9 v klinick\u00fdch studi\u00edch pro udr\u017een\u00ed krevn\u00edho tlaku b\u011bhem chirurgick\u00fdch operac\u00ed.<\/p>\n

Aplikace<\/strong>
\nL\u00e9\u010dba dekompenzovan\u00e9ho m\u011bstnav\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed.<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Carperitide Acetate\/ANP 1-28, HUMAN
\nCAS: 89213-87-6
\nMF: C127H203N45O39S3
\nMW: 3080,44
\nEINECS: 686-482-9
\nMol File: 89213-87-6.mol<\/p>\n","protected":false},"featured_media":2286,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[491],"product_tag":[2449,2471],"class_list":{"0":"post-7293","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptid-kardiovaskularniho-systemu","7":"product_tag-carperitide-acetate-anp-1-28-cs","8":"product_tag-human-cas-89213-87-6-for-treatment-of-congestive-heart-failure-cs","9":"desktop-align-left","10":"tablet-align-left","11":"mobile-align-left","13":"first","14":"instock","15":"shipping-taxable","16":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/7293","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=7293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2286"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=7293"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=7293"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=7293"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=7293"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}