{"id":8086,"date":"2021-12-16T12:17:36","date_gmt":"2021-12-16T17:17:36","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/zikonotidacetat-cas-107452-89-1-lecba-pro-postherpetickou-neuralgii-a-rakovinovou-bolest\/"},"modified":"2021-12-16T12:17:36","modified_gmt":"2021-12-16T17:17:36","slug":"zikonotidacetat-cas-107452-89-1-lecba-pro-postherpetickou-neuralgii-a-rakovinovou-bolest","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/zikonotidacetat-cas-107452-89-1-lecba-pro-postherpetickou-neuralgii-a-rakovinovou-bolest\/","title":{"rendered":"Zikonotidacet\u00e1t CAS 107452-89-1 L\u00e9\u010dba pro postherpetickou neuralgii a rakovinovou bolest"},"content":{"rendered":"

Zikonotidacet\u00e1t CAS 107452-89-1 L\u00e9\u010dba pro postherpetickou neuralgii a rakovinovou bolest<\/strong><\/h2>\n

N\u00e1zev produktu: Zikonotidacet\u00e1t
\nSynonyma: OMEGA-CONOTOXIN MVIIA;OMEGA-CGTX MVII A;ZICONOTIDE ACETATE;snx111;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG -LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS -SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDOV\u00dd M\u016eSTEK: 1-16, 8-20 A 15 -25);CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY- LYS-CYS-NH2;CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFIDOV\u00dd M\u016eSTEK: 1-16,8-20, AND 15-25)
\nCAS: 107452-89-1
\nMF: C102H172N36O32W9S7<113O&M32S7<11 >EINECS:
\nKategorie produkt\u016f: Peptid
\nMol Soubor: 107452-89-1.mol<\/p>\n

Zikonotid (Prialt) je 25 aminokyselinov\u00e1, t\u0159i disulfidicky v\u00e1zan\u00e1 peptidov\u00e1 toxinov\u00e1 slou\u010denina odvozen\u00e1 z jihu Pacifick\u00fd mo\u0159sk\u00fd \u0161nek Conusmagus. Je to prvn\u00ed nov\u00e1 neuroterapeutick\u00e1 l\u00e1tka – blok\u00e1tor kalciov\u00e9ho kan\u00e1lu N-typu (NCCB). Selektivn\u011b p\u016fsob\u00ed na elektrosenzitivn\u00ed v\u00e1pn\u00edkov\u00e9 kan\u00e1ly Chemicalbook typu N v dendritick\u00fdch a axon\u00e1ln\u00edch koncov\u00fdch v\u011btv\u00edch, \u010d\u00edm\u017e inhibuje po\u010d\u00e1te\u010dn\u00ed aferentn\u00ed stimuly poran\u011bn\u00ed. Je indikov\u00e1n u pacient\u016f s t\u011b\u017ekou chronickou bolest\u00ed, kte\u0159\u00ed vy\u017eaduj\u00ed intratek\u00e1ln\u00ed l\u00e9\u010dbu a kte\u0159\u00ed netoleruj\u00ed nebo maj\u00ed n\u00edzkou \u00fa\u010dinnost jin\u00e9 analgetick\u00e9 l\u00e9\u010dby (nap\u0159. aplikace syst\u00e9mov\u00fdch analgetik nebo intratek\u00e1ln\u00edho morfinu). Intratek\u00e1ln\u00ed zikonotid lze pou\u017e\u00edt k l\u00e9\u010db\u011b postherpetick\u00e9 neuralgie, fantomov\u00e9 bolesti kon\u010detin, neuropatick\u00e9 bolesti souvisej\u00edc\u00ed s HIV, refraktern\u00ed rakovinov\u00e9 bolesti a poopera\u010dn\u00ed bolesti.<\/p>\n

Zikonotidacet\u00e1t CAS 107452-89-1 Chemick\u00e9 vlastnosti<\/strong>
\nhustota 1,60\u00b10,1 g\/cm3 (p\u0159edpokl\u00e1dan\u00e1)
\ntepl. -20\u00b0C
\nInChIKey BPKIMPVREBSLAJ-QTBYCLKRSA-N<\/p>\n

Pou\u017eit\u00ed zikonotidacet\u00e1tu CAS 107452-89-1<\/strong>
\nLigand pro vazebn\u00e9 studie nap\u011b\u0165ov\u011b citliv\u00fdch v\u00e1pn\u00edkov\u00fdch kan\u00e1l\u016f.<\/p>\n

Zikonotid ( SNX-111; Prialt), tak\u00e9 naz\u00fdvan\u00fd intratek\u00e1ln\u00ed zikonotid (ITZ) kv\u016fli sv\u00e9mu zp\u016fsobu pod\u00e1n\u00ed, je atypick\u00e9 analgetikum pro zm\u00edrn\u011bn\u00ed siln\u00e9 a chronick\u00e9 bolesti. Poch\u00e1z\u00ed z Conus magus, \u0161neka ku\u017eelovit\u00e9ho, je to syntetick\u00e1 forma \u03c9-konotoxinov\u00e9ho peptidu.[1] Je 1000kr\u00e1t siln\u011bj\u0161\u00ed ne\u017e morfinie.<\/p>\n

Tento produkt je vhodn\u00fd pro pacienty s t\u011b\u017ekou chronickou bolest\u00ed, kte\u0159\u00ed vy\u017eaduj\u00ed intratek\u00e1ln\u00ed l\u00e9\u010dbu a kte\u0159\u00ed netoleruj\u00ed nebo maj\u00ed n\u00edzkou \u00fa\u010dinnost jin\u00e9 analgetick\u00e9 l\u00e9\u010dby (jako je aplikace syst\u00e9mov\u00fdch analgetik nebo intratek\u00e1ln\u00ed injekce morfinu atd.).<\/p>\n

Funkce a aplikace zikonotidacet\u00e1tu CAS 107452-89-1<\/strong>
\n1. Analgetick\u00e1 \u00fa\u010dinnost Zikonotid je vhodn\u00fd pro pacienty s chronickou bolest\u00ed, kte\u0159\u00ed netoleruj\u00ed nebo nereaguj\u00ed na jinou l\u00e9\u010dbu, v\u010detn\u011b syst\u00e9mov\u00e9 medikace, adjuvantn\u00ed l\u00e9\u010dby intratek\u00e1ln\u00ed injekc\u00ed morfinu. Intratek\u00e1ln\u00ed injekce zikonotidu m\u00e1 klinicky a statisticky v\u00fdznamnou analgetickou \u00fa\u010dinnost u pacient\u016f s rakovinou nebo AIDS.<\/p>\n

2. Ochrana m\u00edchy Kr\u00e1tkodob\u00e1 ischemie m\u00edchy P\u0159i po\u0161kozen\u00ed m\u00ed\u0161n\u00edch neuron\u016f doch\u00e1z\u00ed k aktivaci elektrosenzitivn\u00ed kalciov\u00e9 dr\u00e1hy typu N. Zikonotid m\u016f\u017ee poskytnout neuroprotekci a analgezii b\u011bhem operace aorty.<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Zikonotidacet\u00e1t
\nCAS: 107452-89-1
\nMF: C102H172N36O32S7
\nMW: 2639,13
\nMol Soubor: 107452-89-1.mol<\/p>\n","protected":false},"featured_media":2202,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[515],"product_tag":[1570],"class_list":{"0":"post-8086","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-jine-peptidy","7":"product_tag-ziconotide-acetate-cas-107452-89-1-treat-for-postherpetic-neuralgia-and-cancer-pain-cs","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8086"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2202"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8086"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8086"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8086"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}