{"id":8210,"date":"2021-12-16T12:24:47","date_gmt":"2021-12-16T17:24:47","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/thymosin-%ce%b11-thymosin-%ce%b11-acetatethymosin-alpha-1-cas-162304-98-7-pro-lecbu-chronicke-hepatitidy-b-a-posileni-imunitniho-systemu\/"},"modified":"2021-12-16T12:24:47","modified_gmt":"2021-12-16T17:24:47","slug":"thymosin-%ce%b11-thymosin-%ce%b11-acetatethymosin-alpha-1-cas-162304-98-7-pro-lecbu-chronicke-hepatitidy-b-a-posileni-imunitniho-systemu","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/thymosin-%ce%b11-thymosin-%ce%b11-acetatethymosin-alpha-1-cas-162304-98-7-pro-lecbu-chronicke-hepatitidy-b-a-posileni-imunitniho-systemu\/","title":{"rendered":"Thymosin \u03b11\/ Thymosin \u03b11 \/ AcetateThymosin Alpha 1 CAS 162304-98-7 Pro l\u00e9\u010dbu chronick\u00e9 hepatitidy B a pos\u00edlen\u00ed imunitn\u00edho syst\u00e9mu"},"content":{"rendered":"

Thymosin \u03b11\/ Thymosin \u03b11 \/ AcetateThymosin Alpha 1 CAS 162304-98-7 Pro l\u00e9\u010dbu chronick\u00e9 hepatitidy B a pos\u00edlen\u00ed imunitn\u00edho syst\u00e9mu<\/strong><\/h2>\n

N\u00e1zev produktu: Thymosin \u03b11
\nSekvence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu -Lys-Glu-Val-Glu-Glu-Ala-Glu-Ala-Glu-Asn-OH
\nSynonyma: THYMOSIN ALPHA 1;THYMOSIN ALPHA1 BOVINE;THYMOSIN APHA 1;ZADAXIN;Thymosin \u03b11-acet\u00e1t;Thymatesin acetat\u03b1;S\u016fl thymosin; Acet\u00e1tov\u00e1 s\u016fl; Thymosin \u03b1 1 Acetate (Thymalfasin)
\nCAS: 62304-98-7
\nMF: C129H215N33O55
\nMW: 3108,32
\nEINECS: 1592732&453-0 Kategorie produkt\u016f: Aminokyseliny Deriv\u00e1ty;Peptid;R\u016fzn\u00e9 peptidy
\nMol File: 62304-98-7.mol<\/p>\n

Thymosin-al (T-al), syntetick\u00fd peptid s 28 aminokyselinami s mnoha biologick\u00fdmi aktivitami prim\u00e1rn\u011b zam\u011b\u0159en\u00fdmi na imunitn\u00ed odpov\u011b\u010f Tento l\u00e9k se pou\u017e\u00edv\u00e1 k l\u00e9\u010db\u011b infekc\u00ed virem HBV a hepatitidy C (HCV) a je vyv\u00edjen pro l\u00e9\u010dbu nemalobun\u011b\u010dn\u00e9ho karcinomu plic (NSCLC), hepatocelul\u00e1rn\u00edho karcinomu, AIDS a malign\u00edho melanomu. T-\u03b11 je schopen potencovat \u00fa\u010dinek cytokin\u016f a tak\u00e9 sn\u00ed\u017eit hematologickou toxicitu cytotoxick\u00e9 medikament\u00f3zn\u00ed terapie, jako je cyklofosfamid, 5-fluorouracil, dakarbazin.<\/p>\n

Thymosin \u03b11\/ Thymosin \u03b11 \/ AcetateThymosin Alpha 1 CAS 162304- 98-7 Chemick\u00e9 vlastnosti<\/strong>
\nBod varu 2899,7\u00b165,0 \u00b0C (p\u0159edpokl\u00e1dan\u00e1)
\nhustota 1,360\u00b10,06 g\/cm3 (p\u0159edpokl\u00e1dan\u00e1)
\ntepl. \u221220\u00b0C
\nrozpustnost Doporu\u010duje se rekonstituovat lyofilizovan\u00fd Thymosin a1 ve steriln\u00ed 18M\u03a9-cm H2O ne m\u00e9n\u011b ne\u017e 100 \u03bcg\/ml, kter\u00fd pak lze d\u00e1le na\u0159edit na jin\u00e9 vodn\u00e9 roztoky.
\nbarva Steriln\u00ed Filtrovan\u00fd B\u00edl\u00fd lyofilizovan\u00fd (lyofilizovan\u00fd) pr\u00e1\u0161ek.
\nStabilita: Lyofilizovan\u00fd Thymosin a1, i kdy\u017e je stabiln\u00ed p\u0159i pokojov\u00e9 teplot\u011b po dobu 3 t\u00fddn\u016f, by m\u011bl b\u00fdt skladov\u00e1n vysu\u0161en\u00fd pod -18\u00b0C. Po rekonstituci by m\u011bl b\u00fdt Thymalfasin uchov\u00e1v\u00e1n p\u0159i teplot\u011b 4 \u00b0C po dobu 2\u20137 dn\u016f a pro budouc\u00ed pou\u017eit\u00ed p\u0159i teplot\u011b ni\u017e\u0161\u00ed ne\u017e -18 \u00b0C.
\nPro dlouhodob\u00e9 skladov\u00e1n\u00ed se doporu\u010duje p\u0159idat nosn\u00fd protein (0,1 % HSA nebo BSA).<& >Zabra\u0148te cykl\u016fm zmrazov\u00e1n\u00ed a rozmrazov\u00e1n\u00ed.<\/p>\n

Funkce a aplikace Thymosinu \u03b11\/Tymosinu \u03b11\/Acet\u00e1tuThymosinu Alpha 1 CAS 162304-98-7<\/strong>
\nThymosin \u03b11 je chemicky syntetizovan\u00fd thymosin \u03b11, kter\u00fd je identick\u00fd s lidsk\u00fdm thymosinem \u03b11. Thymosin al je acetylovan\u00fd polypeptid. Thymosin \u03b11 je v sou\u010dasnosti schv\u00e1len pro l\u00e9\u010dbu hepatitidy B a C ve 35 rozvojov\u00fdch zem\u00edch. Thymosin \u03b11 se tak\u00e9 pou\u017e\u00edv\u00e1 k pos\u00edlen\u00ed imunitn\u00ed odpov\u011bdi p\u0159i l\u00e9\u010db\u011b jin\u00fdch onemocn\u011bn\u00ed.<\/p>\n

Thymosin alpha 1 V\u00fdhody<\/strong>
\nThymalfasin (thymosin-alpha 1) je imunomodula\u010dn\u00ed \u010dinidlo schopn\u00e9 zv\u00fd\u0161it Thl imunitn\u00ed odpov\u011b\u010f. In vitro: konjugace thymalfasinu (T\u03b11) s iRGD zachov\u00e1v\u00e1 imunomodula\u010dn\u00ed aktivitu l\u00e9\u010diva zv\u00fd\u0161en\u00edm proliferace lymfocyt\u016f my\u0161\u00ed sleziny. D\u00e1le, ve srovn\u00e1n\u00ed s o\u0161et\u0159en\u00edm Ta1, o\u0161et\u0159en\u00ed bun\u011bk MCF-7 Ta1-iRGD v\u00fdrazn\u011b zvy\u0161uje po\u010det bun\u011bk podl\u00e9haj\u00edc\u00edch apopt\u00f3ze, co\u017e vede k inhibici r\u016fstu rakovinn\u00fdch bun\u011bk v z\u00e1vislosti na d\u00e1vce. <\/p>\n

In vivo: Thymalfasin se uk\u00e1zal jako \u00fa\u010dinn\u00fd u mnoha experiment\u00e1ln\u00edch model\u016f imunitn\u00ed dysfunkce, zejm\u00e9na u infek\u010dn\u00edch onemocn\u011bn\u00ed, jako je hepatitida (sv\u016fj lesn\u00ed) a ch\u0159ipka (my\u0161\u00ed), a rakoviny, jako je melanom (my\u0161) a kolorekt\u00e1ln\u00ed karcinom (krysa), kde thymalfasin prok\u00e1zal protin\u00e1dorov\u00e9 \u00fa\u010dinky. <\/p>\n

Thymosin alpha 1 D\u00e1vkov\u00e1n\u00ed<\/strong>
\nTo z\u00e1vis\u00ed na va\u0161\u00ed t\u011blesn\u00e9 hmotnosti. V\u0161echny dosud proveden\u00e9 v\u00fdzkumy vyu\u017e\u00edvaly studie na hlodavc\u00edch, krys\u00e1m a my\u0161\u00edm se obvykle injek\u010dn\u011b aplikuje \u00fa\u010dinn\u00e1 d\u00e1vka, kter\u00e1 se odhaduje na p\u0159ibli\u017en\u011b 10 \u03bcg (mcg) na kg, u lid\u00ed se p\u0159edpokl\u00e1d\u00e1, \u017ee se jedn\u00e1 o ekvivalentn\u00ed d\u00e1vku 1,6 \u03bcg. na KG u lid\u00ed, tak\u017ee pokud jste: <\/p>\n

60 KG (132 lb.), va\u0161e ide\u00e1ln\u00ed denn\u00ed peror\u00e1ln\u00ed d\u00e1vka BPC-157 by byla 96 \u03bcg (mcg)
\n70 KG (154 lb.) = > 112 \u03bcg
\n80 KG (176 lb.) => 128 \u03bcg
\n90 KG (198 lb.) => 144 \u03bcg<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Thymosin \u03b11
\nCAS: 62304-98-7
\nMF: C129H215N33O55
\nMW: 3108,32
\nEINECS: 1592732-453-0
\nMol Soubor: 627304-98<\/p>\n","protected":false},"featured_media":2097,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[364],"product_tag":[1474],"class_list":{"0":"post-8210","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-imunomodulacni-peptid","7":"product_tag-thymosin-1-thymosin-1-acetatethymosin-alpha-1-cas-162304-98-7-for-treat-chronic-hepatitis-b-and-boosting-the-immune-system-cs","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8210"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2097"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8210"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8210"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8210"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}