{"id":8314,"date":"2021-12-16T13:22:14","date_gmt":"2021-12-16T18:22:14","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/vysoce-kvalitni-peptid-somatostatin-acetat-15-28-somatostatin-28-cas-38916-34-6\/"},"modified":"2021-12-16T13:22:14","modified_gmt":"2021-12-16T18:22:14","slug":"vysoce-kvalitni-peptid-somatostatin-acetat-15-28-somatostatin-28-cas-38916-34-6","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/vysoce-kvalitni-peptid-somatostatin-acetat-15-28-somatostatin-28-cas-38916-34-6\/","title":{"rendered":"Vysoce kvalitn\u00ed peptid somatostatin acet\u00e1t\/ 15-28-somatostatin-28 CAS 38916-34-6"},"content":{"rendered":"

Vysoce kvalitn\u00ed peptid somatostatin acet\u00e1t\/ 15-28-somatostatin-28 CAS 38916-34-6<\/strong><\/h2>\n

N\u00e1zev produktu: Somatostatin acet\u00e1t\/ 15-28-Somatostatin-28
\nSynonyma: Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH ;Faktor inhibuj\u00edc\u00ed uvol\u0148ov\u00e1n\u00ed SoMatotropinu, SRIF, SRIF-14;Cyklick\u00fd somatostatin;SoMatostatin Acetat;FAKTOR INHIBITUJ\u00cdC\u00cd UVOL\u0147OV\u00c1N\u00cd R\u016eSTOV\u00c9HO HORMONU (\u010cLOV\u011aK, OVCE, PRAS\u00c1TKA, KRAS, MY\u0160);FAKTOR INHIBITUJ\u00cdC\u00cd UVOL\u0147OV\u00c1N\u00cd R\u016eSTOV\u00c9HO HORMONU (INHUBITUJ\u00cdC\u00cd FAKTOR R\u016eSTOV\u00c9HO HORMONU, FAKTOR R\u016eSTOV\u00c9HO HORMU MY\u0160) 2ACOH 6H2O;H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH;H-ALA-GLY-CYS-LYS-ASN-PHE -PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (SPOJENO S BSA)
\nCAS: 38916-34-6
\nMF: C76H104N18O19S2
\nMW: 1637,88
\nEINECS: 254-186-5
\nKategorie produkt\u016f: Deriv\u00e1ty aminokyselin;Aminokyseliny a deriv\u00e1ty;Peptid;Aminokyseliny 13C, 2H, 15N;Meziprodukty a jemn\u00e9 chemik\u00e1lie;Farmaceutika;peptidy pharm
\nMol File: 38-916- 38-916- .mol<\/p>\n

Somatostatin je cyklick\u00fd 14-peptid, kter\u00fd byl poprv\u00e9 izolov\u00e1n Guilleminem v roce 1973 a je pravd\u011bpodobn\u011b nejd\u016fkladn\u011bji prozkouman\u00fdm a nejd\u016fle\u017eit\u011bj\u0161\u00edm z inhibi\u010dn\u00edch faktor\u016f produkovan\u00fdch hypothou. lamus. Hlavn\u00ed aktivitou somatostatinu, kter\u00fd je hypotalamick\u00e9ho p\u016fvodu, je inhibice uvol\u0148ov\u00e1n\u00ed r\u016fstov\u00e9ho hormonu (GH) z p\u0159edn\u00edho laloku hypof\u00fdzy. P\u0159\u00edli\u0161 mnoho GH, jako u n\u00e1dor\u016f hypof\u00fdzy, zp\u016fsobuje akromegalii, formu gigantismu. Na druhou stranu p\u0159\u00edli\u0161 m\u00e1lo GH vede k nanismu. Somatostatin byl tak\u00e9 nalezen ve slinivce b\u0159i\u0161n\u00ed a v gastrointestin\u00e1ln\u00edm traktu, kde inhibuje sekreci inzul\u00ednu a glukagonu ze slinivky b\u0159i\u0161n\u00ed a tak\u00e9 sekreci r\u016fzn\u00fdch st\u0159evn\u00edch peptid\u016f (nap\u0159. gastrin, sekretin, pepsin a renin). Kr\u00e1tk\u00fd polo\u010das somatostatinu, kter\u00fd je m\u00e9n\u011b ne\u017e 3 minuty, znemo\u017e\u0148uje jeho pou\u017eit\u00ed jako terapeutick\u00e9ho \u010dinidla. Bylo p\u0159ipraveno mnoho deriv\u00e1t\u016f somatostatinu, aby se prodlou\u017eila doba jeho p\u016fsoben\u00ed a\/nebo aby se zv\u00fd\u0161ila jeho selektivita p\u016fsoben\u00ed. Vyvrcholen\u00edm t\u011bchto strukturn\u011b-aktivitn\u00edch studi\u00ed byl v\u00fdvoj octreotidacet\u00e1tu.<\/p>\n

Krom\u011b hypotalamu byly pou\u017eity dal\u0161\u00ed \u010d\u00e1sti, jako je mozkov\u00e1 k\u016fra, striatum, amygdala, hippocampus a m\u00edcha, sympatick\u00fd nerv, gastrointestin\u00e1ln\u00ed, ostr\u016fvk\u016f, ledvin, \u0161t\u00edtn\u00e9 \u017el\u00e1zy a p\u0159\u00ed\u0161t\u00edtn\u00fdch t\u011bl\u00edsek jsou \u0161iroce distribuov\u00e1ny v somatostatinu. V mozku a gastrointestin\u00e1ln\u00edm traktu bylo purifikov\u00e1no 28 aminokyselin GHRIH28, co\u017e je vn\u011bj\u0161\u00ed prodlou\u017een\u00ed N-konce GHRIH14. \u00da\u010dinek somatostatinu in vitro je komplikovan\u00fd a m\u016f\u017ee p\u016fsobit jako p\u0159ena\u0161e\u010d nebo modulovat v nervov\u00e9m syst\u00e9mu; somatostatin m\u00e1 ur\u010dit\u00fd inhibi\u010dn\u00ed \u00fa\u010dinek na gastrointestin\u00e1ln\u00ed motilitu a sekreci hormon\u016f tr\u00e1vic\u00edho traktu; inhibuje tak\u00e9 inzul\u00edn a slinivku sekreci glukagonu, reninu, parathormonu a kalcitoninu.<\/p>\n

Somatostatin acet\u00e1t\/15-28-Somatostatin-28 CAS 38916-34-6 Chemick\u00e9 vlastnosti<\/strong>
\n15-28-Somatostatin-28 Chemick\u00e9 vlastnosti
\nBod varu 1970,9\u00b165,0 \u00b0C (p\u0159edpokl\u00e1dan\u00e1)
\nhustota 1,43\u00b10,1 g\/cm3 (p\u0159edpokl\u00e1dan\u00e1)
\ntepl. \u221220\u00b0C
\nrozpustnost H2O: 1 mg\/mL
\npka 2,94\u00b10,70(p\u0159edpov\u011bzen\u00e1)
\nforma pr\u00e1\u0161ku
\nrozpustnost ve vod\u011b Rozpustn\u00fd ve vod\u011b (25,00\u00b0C 1,00 g\/L) , Methanol.
\nMerck 13,8788
\nBRN 6436064
\nInChIKey NHXLMOGPVYXJNR-ATOGVRKGSA-N<\/p>\n

Funkce a aplikace somatostatin acet\u00e1t\/15-28-somatostatin-28 CAS<\/strong> <& >
\n1 M\u016f\u017ee inhibovat sekreci r\u016fstov\u00e9ho hormonu, hormonu stimuluj\u00edc\u00edho \u0161t\u00edtnou \u017el\u00e1zu, inzul\u00ednu, glukagonu.<\/p>\n

2 M\u016f\u017ee inhibovat sekreci \u017ealude\u010dn\u00ed kyseliny stimulovanou testovac\u00edm j\u00eddlem a 5-peptidov\u00fdm gastrinem a m\u016f\u017ee inhibovat uvol\u0148ov\u00e1n\u00ed pepsinu a gastrinu.<\/p>\n

3 M\u016f\u017ee v\u00fdrazn\u011b sn\u00ed\u017eit viscer\u00e1ln\u00ed pr\u016ftok krve, sn\u00ed\u017eit port\u00e1ln\u00ed tlak, sn\u00ed\u017eit pr\u016ftok krve a tlak kolater\u00e1ln\u00edho ob\u011bhu, sn\u00ed\u017eit pr\u016ftok krve j\u00e1try.<\/p>\n

4 Sni\u017euje sekreci slinivky b\u0159i\u0161n\u00ed a sekrece tenk\u00e9ho st\u0159eva a \u017elu\u010dn\u00edku, sni\u017euj\u00ed aktivitu enzym\u016f a maj\u00ed ochrann\u00fd \u00fa\u010dinek na bu\u0148ky slinivky b\u0159i\u0161n\u00ed.<\/p>\n

5 M\u016f\u017ee ovlivnit vst\u0159eb\u00e1v\u00e1n\u00ed a nutri\u010dn\u00ed funkci gastrointestin\u00e1ln\u00edho traktu.<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Somatostatin Acetate\/ 15-28-Somatostatin-28
\nCAS: 38916-34-6
\nMF: C76H104N18O19S2
\nMW: 1637,88
\nEINECS: 254-186-5
\nMol File : 38916-34-6.mol<\/p>\n","protected":false},"featured_media":2118,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[515],"product_tag":[],"class_list":{"0":"post-8314","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-jine-peptidy","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8314"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2118"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8314"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8314"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8314"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}