{"id":8351,"date":"2021-12-16T13:24:44","date_gmt":"2021-12-16T18:24:44","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/puya-supply-calcitonin-losos-cas-47931-85-1-pro-osteoporozu\/"},"modified":"2021-12-16T13:24:44","modified_gmt":"2021-12-16T18:24:44","slug":"puya-supply-calcitonin-losos-cas-47931-85-1-pro-osteoporozu","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/puya-supply-calcitonin-losos-cas-47931-85-1-pro-osteoporozu\/","title":{"rendered":"Puya Supply Calcitonin losos CAS 47931-85-1 pro osteopor\u00f3zu"},"content":{"rendered":"

Puya Supply Calcitonin losos CAS 47931-85-1 pro osteopor\u00f3zu<\/strong><\/h2>\n

N\u00e1zev produktu: Calcitonin losos
\nSynonyma: lososov\u00fd kalcitonin-(i-32);salmoncalcitonini;tz-ct;lososov\u00fd kalcitonin acet\u00e1t;Salcatonin;CALCITONIN LOSOS 250 UG;kalcitoninacet\u00e1t;lososov\u00fd v\u00e1pn\u00edk<-[&>Sekvence: H Cys-Ser-Asn-Leu-Ser-Thr-Cys]-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr -Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2\uff0c(disulfidov\u00fd m\u016fstek: Cys1-Cys7)
\nCAS: 47931-85-1
\nMF: C145H240N44O48S2
\nMW: 3431,85
\n EINECS: 256-342-8
\nKategorie produkt\u016f: Deriv\u00e1ty aminokyselin;Peptid;Kalcitonin a receptor CGRP
\nSoubor Mol: 47931-85-1.mol<\/p>\n

Kalcitonin Losos je polypeptidov\u00fd hormon vylu\u010dovan\u00fd ultimobranchi\u00e1ln\u00ed \u017el\u00e1za lososa. Pat\u0159\u00ed do rodiny protein\u016f podobn\u00fdch kalcitoninu a lze jej pou\u017e\u00edt k l\u00e9\u010db\u011b Pagetovy nemoci kost\u00ed, postmenopauz\u00e1ln\u00ed osteopor\u00f3zy (k\u0159ehk\u00e9 nebo k\u0159ehk\u00e9 kosti) nebo vysok\u00e9 hladiny v\u00e1pn\u00edku v krvi (hyperkalc\u00e9mie). Zd\u00e1 se, \u017ee m\u00e1 \u00fa\u010dinky v podstat\u011b identick\u00e9 s kalcitoniny sav\u010d\u00edho p\u016fvodu, ale jeho \u00fa\u010dinnost na mg je vy\u0161\u0161\u00ed a m\u00e1 del\u0161\u00ed trv\u00e1n\u00ed \u00fa\u010dinku. P\u016fsob\u00ed p\u0159edev\u0161\u00edm inhibic\u00ed osteoklastick\u00e9 kostn\u00ed resorpce, sn\u00ed\u017een\u00edm s\u00e9rov\u00e9ho v\u00e1pn\u00edku a zv\u00fd\u0161en\u00edm ren\u00e1ln\u00edho vylu\u010dov\u00e1n\u00ed fosf\u00e1tu, v\u00e1pn\u00edku, sod\u00edku, ho\u0159\u010d\u00edku a drasl\u00edku sn\u00ed\u017een\u00edm tubul\u00e1rn\u00ed reabsorpce.<\/p>\n

P\u0159irozen\u00fd kalcitonin je bioaktivn\u00ed peptid vylu\u010dovan\u00fd bu\u0148kami p\u0159\u00ed\u0161t\u00edtn\u00fdch t\u011bl\u00edsek savc\u016f nebo zadn\u00ed \u017e\u00e1bry obratlovc\u016f a je hlavn\u00edm regul\u00e1torem metabolismu v\u00e1pn\u00edku v \u017eiv\u00fdch organismech. Lososov\u00fd kalcitonin acet\u00e1t je syntetick\u00fd 32-peptid a v klinick\u00e9m v\u00fdzkumu byl losos\u00ed kalcitonin \u0161iroce pou\u017e\u00edv\u00e1n na klinice jako preventivn\u00ed a l\u00e9\u010debn\u00fd l\u00e9k na osteopor\u00f3zu a dal\u0161\u00ed metabolick\u00e1 onemocn\u011bn\u00ed kost\u00ed.<\/p>\n

Chemick\u00e9 vlastnosti kalcitoninu lososa CAS 47931-85-1<\/strong>
\nkalcitonin losos Chemick\u00e9 vlastnosti
\nhustota 1,54\u00b10,1 g\/cm3 (p\u0159edpoklad)
\ntepl. \u221220 \u00b0C
\nrozpustnost 0,05 M kyselina octov\u00e1: 1 mg\/ml, \u010dir\u00e1, bezbarv\u00e1
\nforma pr\u00e1\u0161ku
\nRozpustnost ve vod\u011b Rozpustn\u00e1 ve vod\u011b p\u0159i 1 mg\/ml
\nMerck 13,1642
\nInChIKey IYTKRMFJECGBRF -LXQLIYPUSA-N
\nCAS DataBase Reference 47931-85-1 (CAS Database Reference)<\/p>\n

Funkce a aplikace kalcitoninov\u00e9ho lososa CAS 47931-85-1<\/strong>
\n1. Kalcitoninov\u00fd losos lze pou\u017e\u00edt pro test kalcitoninov\u00e9ho receptoru\/cAMP pro hodnocen\u00ed p\u0159\u00edtomnosti kalcitoninov\u00fdch receptor\u016f exprimovan\u00fdch bu\u0148kami TRAP+. Produkt lze tak\u00e9 pou\u017e\u00edt jako testovac\u00ed slou\u010deninu pro studium a tak\u00e9 pro porovn\u00e1n\u00ed vlivu peptidu souvisej\u00edc\u00edho s genem kalcitoninu (CGRP) a losos\u00ed kalcitonin (sCT) na \u017ealude\u010dn\u00ed slizni\u010dn\u00ed bari\u00e9\u0159e u potkan\u016f vystaven\u00fdch chladu + omezovac\u00edho stresu (CRS). [sigma-aldrich]
\n2. Calcitonin, Losos je v\u00e1pn\u00edk reguluj\u00edc\u00ed hormon vylu\u010dovan\u00fd z parafolikul\u00e1rn\u00edch bun\u011bk \u0161t\u00edtn\u00e9 \u017el\u00e1zy savc\u016f a u jin\u00fdch ne\u017e sav\u010d\u00edch druh\u016f z ultimobranchi\u00e1ln\u00ed \u017el\u00e1zy. Kalcitoniny jsou jedno\u0159et\u011bzcov\u00e9 polypeptidy obsahuj\u00edc\u00ed 32 aminokyselinov\u00fdch zbytk\u016f, vykazuj\u00edc\u00ed hypokalcemick\u00fd a hypofosfatemick\u00fd \u00fa\u010dinek, s odli\u0161nou strukturou aminokyselin mezi druhy savc\u016f. Losos\u00ed kalcitonin (salcatonin je syntetick\u00fd analog) vykazuje v\u00fdrazn\u011b odli\u0161nou sekvenci ne\u017e u vy\u0161\u0161\u00edch obratlovc\u016f a tak\u00e9 siln\u011bj\u0161\u00ed aktivitu. \u00daho\u0159\u00ed kalcitonin (Elcatonin) m\u00e1 podobnou aminokyselinu jako losos\u00ed forma, ale je stabiln\u011bj\u0161\u00ed ne\u017e p\u0159\u00edrodn\u00ed kalcitoniny kv\u016fli absenci disulfidov\u00fdch m\u016fstk\u016f. [Biotechnologie Santa Cruz]
\n3. Vykazuje hypokalcemick\u00fd a hypofosfatemick\u00fd \u00fa\u010dinek, p\u0159i\u010dem\u017e struktura aminokyselin se mezi druhy savc\u016f li\u0161\u00ed. Losos\u00ed kalcitonin (salcatonin je syntetick\u00fd analog) vykazuje v\u00fdrazn\u011b odli\u0161nou sekvenci ne\u017e u vy\u0161\u0161\u00edch obratlovc\u016f a tak\u00e9 siln\u011bj\u0161\u00ed aktivitu. Sni\u017euje hladinu v\u00e1pn\u00edku a fosf\u00e1tu v krvi v d\u016fsledku inhibice resorpce osteoblasty a osteocyty. [alfa-aesar]
\n4. Peptidov\u00fd hormon reguluj\u00edc\u00ed v\u00e1pn\u00edk ze \u0161t\u00edtn\u00e9 \u017el\u00e1zy. Sni\u017euje koncentraci v\u00e1pn\u00edku v krvi a sni\u017euje kostn\u00ed resorpci osteoklasty. Pou\u017e\u00edv\u00e1 se pro terapeutick\u00e9 aplikace p\u0159i osteopor\u00f3ze. Peptidov\u00e1 sekvence losos\u00edho kalcitoninu se li\u0161\u00ed od sav\u010d\u00ed, ale je \u00fa\u010dinn\u011bj\u0161\u00ed.[Enzo Life Sciences, Inc.]<\/p>\n

Pou\u017eit\u00ed losos\u00edho kalcitoninu CAS 47931-85-1<\/strong>
\nOsteopor\u00f3za;Hyperkalc\u00e9mie; Pagetova nemoc; Reflexn\u00ed sympatick\u00e1 dystrofie (algodistrofie nebo Sudeckova choroba)<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Calcitonin losos
\nCAS: 47931-85-1
\nMF: C145H240N44O48S2
\nMW: 3431,85
\nEINECS: 256-342-8
\nMol Soubor: 47931-85-1,mol<\/p>\n","protected":false},"featured_media":2097,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[474],"product_tag":[1313],"class_list":{"0":"post-8351","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptid-osteoporozy","7":"product_tag-puya-supply-calcitonin-salmon-cas-47931-85-1-for-osteoporosis-cs","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8351"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2097"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8351"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8351"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8351"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}