{"id":8371,"date":"2021-12-16T13:25:56","date_gmt":"2021-12-16T18:25:56","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/pramlintide-acetate-cas-196078-30-5-je-antidiabetikum-ktere-lze-take-pouzit-pri-vyzkumu-rakoviny-tlusteho-streva\/"},"modified":"2021-12-16T13:25:56","modified_gmt":"2021-12-16T18:25:56","slug":"pramlintide-acetate-cas-196078-30-5-je-antidiabetikum-ktere-lze-take-pouzit-pri-vyzkumu-rakoviny-tlusteho-streva","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/pramlintide-acetate-cas-196078-30-5-je-antidiabetikum-ktere-lze-take-pouzit-pri-vyzkumu-rakoviny-tlusteho-streva\/","title":{"rendered":"Pramlintide Acetate CAS 196078-30-5 je antidiabetikum, kter\u00e9 lze tak\u00e9 pou\u017e\u00edt p\u0159i v\u00fdzkumu rakoviny tlust\u00e9ho st\u0159eva"},"content":{"rendered":"

Pramlintide Acetate CAS 196078-30-5 je antidiabetikum, kter\u00e9 lze tak\u00e9 pou\u017e\u00edt p\u0159i v\u00fdzkumu rakoviny tlust\u00e9ho st\u0159eva<\/strong><\/h2>\n

N\u00e1zev produktu: Pramlintid acet\u00e1t
\nSynonyma: AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACET\u00c1T (S\u016eL), HYDR\u00c1T;pramlintidacet\u00e1t; hydr\u00e1t pramlintidacet\u00e1tu ;25-L-Prolin-28-L-prolin-29-L-prolin-aMylin (huMan) acet\u00e1t hydr\u00e1t;AC-137 acet\u00e1t hydr\u00e1t, SyMlin acet\u00e1t hydr\u00e1t; Tripo-aMylin acet\u00e1t hydr\u00e1t; Pramlintid acet\u00e1t, Amylin Rat; Pramlintid acet\u00e1t fandachem
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027,46
\nEINECS:
\nKategorie produkt\u016f: Aminokyseliny a deriv\u00e1ty;Z\u00e1klady a p\u0159\u00edbuzn\u00e1 \u010dinidla;Heterov\u00e1 analoga;Heter & Fine Chemicals;Nucleotides;Peptide;Pharmaceuticals
\nMol File: 196078-30-5.mol<\/p>\n

Pramlintide acet\u00e1t je injek\u010dn\u00ed analog lidsk\u00e9ho amylinu, kter\u00fd byl uveden na trh pro l\u00e9\u010dbu typu 1 i typu 2 diabetes ve spojen\u00ed s inzul\u00ednem. I kdy\u017e je to tak\u00e9 37-aminokyselinov\u00fd peptid, li\u0161\u00ed se od sv\u00e9ho p\u016fvodn\u00edho p\u0159edch\u016fdce substituc\u00ed Ala-25, Ser-28 a Ser-29 proliny. Tyto modifikace nejen zlep\u0161uj\u00ed rozpustnost peptidu, ale tak\u00e9 eliminuj\u00ed agregaci pozorovanou u amylinu, co\u017e vede ke stabiln\u00edmu syntetick\u00e9mu analogu se zachov\u00e1n\u00edm biologick\u00e9 aktivity, kter\u00fd je vhodn\u00fd pro farmaceutick\u00e9 pou\u017eit\u00ed. Jako indikace \u00fa\u010dinnosti inhibuje pramlintid acet\u00e1t vazbu radiojodovan\u00e9ho potkan\u00edho amylinu na membr\u00e1ny potkan\u00edho nucleus accumbens s hodnotou Ki 23 pM. Jeho mechanismus \u00fa\u010dinku napodobuje amylin; jako neurohormon, kter\u00fd je spole\u010dn\u011b sekretov\u00e1n s inzul\u00ednem z pankreatick\u00fdch \u03b2 bun\u011bk v reakci na j\u00eddlo, se pod\u00edl\u00ed na homeost\u00e1ze gluk\u00f3zy. Oba peptidy sni\u017euj\u00ed postprandi\u00e1ln\u00ed hladiny gluk\u00f3zy inhibic\u00ed glukagonu a omezen\u00edm vagusem zprost\u0159edkovan\u00e9 rychlosti vyprazd\u0148ov\u00e1n\u00ed \u017ealudku, \u010d\u00edm\u017e zpomaluj\u00ed st\u0159evn\u00ed absorpci sacharid\u016f. Krom\u011b toho m\u00e1 amylin nebo Pramlintid acet\u00e1t dal\u0161\u00ed v\u00fdhodu v navozen\u00ed postprandi\u00e1ln\u00ed sytosti, co\u017e vede ke ztr\u00e1t\u011b hmotnosti u pacient\u016f s diabetem 2. typu. Proto\u017ee pramlintid-acet\u00e1t zpomaluje vyprazd\u0148ov\u00e1n\u00ed \u017ealudku, je kontraindikov\u00e1n u pacient\u016f s gastropar\u00e9zou a u pacient\u016f u\u017e\u00edvaj\u00edc\u00edch l\u00e9ky, kter\u00e9 m\u011bn\u00ed gastrointestin\u00e1ln\u00ed motilitu (anticholinergika, jako je atropin) nebo zpomaluj\u00ed st\u0159evn\u00ed absorpci \u017eivin (jako jsou inhibitory \u03b1-glukosid\u00e1zy). Pramlintid acet\u00e1t je tak\u00e9 kontraindikov\u00e1n u pacient\u016f s hypoglykemick\u00fdmi sklony; vzhledem k sou\u010dasn\u00e9mu pod\u00e1v\u00e1n\u00ed s inzul\u00ednem je rizikem t\u011b\u017ek\u00e1 hypoglyk\u00e9mie vyvolan\u00e1 inzul\u00ednem. Mezi nej\u010dast\u011bji hl\u00e1\u0161en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky pat\u0159\u00ed nevolnost, zvracen\u00ed, anorexie, bolest hlavy, bolest b\u0159icha, \u00fanava, z\u00e1vrat\u011b, ka\u0161el a faryngitida.<\/p>\n

Funkce a aplikace CAS 196078-30-5<\/strong> <\/p>\n

Pramlintide acet\u00e1t je syntetick\u00fd analog pankreatick\u00e9ho amyloidn\u00edho polypeptidu (Amylin, amylopektin) a je po inzul\u00ednu druh\u00fdm l\u00e9kem schv\u00e1len\u00fdm pro l\u00e9\u010dbu diabetu 1. typu. V klinick\u00e9 praxi se pramlintid pou\u017e\u00edv\u00e1 jako adjuvantn\u00ed l\u00e9k k l\u00e9\u010db\u011b diabetu 1. a 2. typu p\u0159edev\u0161\u00edm u pacient\u016f s diabetem, u kter\u00fdch se nepoda\u0159ilo dos\u00e1hnout o\u010dek\u00e1van\u00fdch v\u00fdsledk\u016f se samotn\u00fdm inzulinem a s kombinac\u00ed inzulinu a sulfonylurey a metforminu. Pramlintid lze pou\u017e\u00edt v kombinaci s inzulinem, ale nem\u016f\u017ee nahradit inzulin.<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Pramlintid acet\u00e1t
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027,46
\nMol Soubor: 196078-30-5.mol<\/p>\n","protected":false},"featured_media":2202,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[339],"product_tag":[1285],"class_list":{"0":"post-8371","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptid-diabetu","7":"product_tag-pramlintide-acetate-cas-196078-30-5-is-an-antidiabetic-agent-that-can-also-be-used-in-bowel-cancer-research-cs","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8371","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8371"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2202"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8371"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8371"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8371"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}