{"id":8413,"date":"2021-12-16T13:28:05","date_gmt":"2021-12-16T18:28:05","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/hot-sale-farmaceuticke-peptidy-pasireotid-cas-396091-73-9\/"},"modified":"2021-12-16T13:28:05","modified_gmt":"2021-12-16T18:28:05","slug":"hot-sale-farmaceuticke-peptidy-pasireotid-cas-396091-73-9","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/hot-sale-farmaceuticke-peptidy-pasireotid-cas-396091-73-9\/","title":{"rendered":"Hot Sale Farmaceutick\u00e9 peptidy Pasireotid CAS 396091-73-9"},"content":{"rendered":"<h2><strong>Hot Sale Farmaceutick\u00e9 peptidy Pasireotid CAS 396091-73-9<\/strong><\/h2>\n<p>N\u00e1zev produktu: PASIREOTIDE<br \/>\nSynonyma: PASIREOTIDE;Cyklo[(2S)-2-fenylglycyl-D-tryptofyl-L-lysyl-O-(fenylmethyl)-L-tyrosyl-L-fenylalanyl-(4R)- 4-[[[(2-aminoethyl)amino]karbonyl]oxy]-L-prolyl];SOM 230;SOM 320;[(3S,6S,9S,12R,15S,18S,20R)-9-(4- aminobutyl)-3-benzyl-12-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-15-fenyl-6-[(4-fenylmethoxyfenyl)methyl]-1, 4,7,10,13,16-hexazabicyklo[16.3.0]henikosan-20-yl] N-(2-aminoethyl)karbam\u00e1t; SOM 230; SOM 320; CYKLO((4R)-4-(2-AMINOETHYLCARBAMOYLOXY) -L-PROLYL-L-FENYLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-FENYLALANYL-)<br \/>\nCAS: 396091-73-9<br \/>\nMF: C58H66N10O9&lt; &gt;MW: 1047,23<br \/>\nEINECS:<br \/>\nKategorie produkt\u016f:<br \/>\nMol File: 396091-73-9.mol<\/p>\n<p>V dubnu 2012 schv\u00e1lila Evropsk\u00e1 komise pasireotid pro l\u00e9\u010dbu Cushingovy choroby ( CD) u dosp\u011bl\u00fdch pacient\u016f, kte\u0159\u00ed nereagovali na chirurgickou intervenci nebo u nich\u017e chirurgick\u00fd z\u00e1krok nen\u00ed mo\u017en\u00fd. Pasireotid byl schv\u00e1len pro stejnou indikaci americkou FDA v prosinci 2012. Pasireotid (tak\u00e9 k nyn\u00ed pod n\u00e1zvem SOM230) je cyklohexapeptid, kter\u00fd p\u016fsob\u00ed jako analog somatostatinu k inhibici uvol\u0148ov\u00e1n\u00ed ACTH. Somatostatiny jsou cyklick\u00e9 peptidy o 14 a 28 aminokyselin\u00e1ch, kter\u00e9 hraj\u00ed d\u016fle\u017eitou roli p\u0159i regulaci endokrinn\u00edho a exokrinn\u00edho uvol\u0148ov\u00e1n\u00ed v mnoha tk\u00e1n\u00edch prost\u0159ednictv\u00edm inhibi\u010dn\u00edho mechanismu. Existuje p\u011bt zn\u00e1m\u00fdch podtyp\u016f somatostatinov\u00fdch receptor\u016f (SSTR). P\u0159\u00edrodn\u00ed somatostatiny se s vysokou afinitou v\u00e1\u017eou na v\u0161ech p\u011bt podtyp\u016f, av\u0161ak jejich terapeutick\u00e9 vyu\u017eit\u00ed je limitov\u00e1no rychlou degradac\u00ed v plazm\u011b. Pasireotid vznikl ze snahy identifikovat somatostatinmimetikum s dlouhodob\u00fdmi inhibi\u010dn\u00edmi \u00fa\u010dinky. Po\u010d\u00ednaje 14-aminokyselinov\u00fdm somatostatinov\u00fdm peptidem, systematick\u00fd alaninov\u00fd sken odhalil zbytky, kter\u00e9 byly nezbytn\u00e9 pro vazbu podtypu receptoru, v\u010detn\u011b kl\u00ed\u010dov\u00fdch oblast\u00ed b-turn a sousedn\u00edch zbytk\u016f. Um\u00edst\u011bn\u00ed kl\u00ed\u010dov\u00fdch strukturn\u00edch prvk\u016f jako nep\u0159irozen\u00e9 aminokyseliny do cyklohexapeptidov\u00e9 kostry poskytlo pasireotid.<\/p>\n<p> <strong>PASIREOTIDE CAS 396091-73-9<\/strong><br \/>\nBod varu 1351,4\u00b165,0 \u00b0C (p\u0159edpokl\u00e1dan\u00e1)<br \/>\nhustota 1,36\u00b10,1 g \/cm3(P\u0159edpov\u011bzeno)<br \/>\npka 11,86\u00b10,46(P\u0159edpov\u011bzeno)<br \/>\nReferen\u010dn\u00ed \u010d\u00edslo datab\u00e1ze CAS 396091-73-9<\/p>\n<p> <strong>Funkce a aplikace PASIREOTIDE CAS 396091-73-9<\/strong><br \/>\nJako inhibitor r\u016fstu analog, kter\u00fd se v\u00e1\u017ee na v\u00edce receptor\u016f, se pasireotid uk\u00e1zal jako \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e analoga inhibitoru r\u016fstu, jako je oktreotid a lanreotid, p\u0159i l\u00e9\u010db\u011b akromegalie, karcinoidn\u00edch n\u00e1dor\u016f a Cushingovy choroby, a to jak v preklinick\u00fdch studi\u00edch, jako jsou bun\u011b\u010dn\u00e9 testy a studie na zv\u00ed\u0159atech, tak v klinick\u00e9 testy. V\u00fdsledky studie f\u00e1ze II a jedna studie f\u00e1ze III t\u00fdkaj\u00edc\u00ed se pasireotidu potvrdily, \u017ee pasireotid je novou l\u00e9\u010dbou nov\u00e9 nebo p\u0159etrv\u00e1vaj\u00edc\u00ed akromegalie a metastatick\u00fdch karcinoidn\u00edch n\u00e1dor\u016f a m\u016f\u017ee b\u00fdt prvn\u00ed volbou l\u00e9kov\u00e9 l\u00e9\u010dby Cushingovy choroby.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>N\u00e1zev produktu: PASIREOTIDE<br \/>\nMF: C58H66N10O9<br \/>\nMW: 1047,23<br \/>\nEINECS:<br \/>\nMol Soubor: 396091-73-9.mol<\/p>\n","protected":false},"featured_media":2202,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[],"product_tag":[],"class_list":{"0":"post-8413","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"desktop-align-left","7":"tablet-align-left","8":"mobile-align-left","10":"first","11":"instock","12":"shipping-taxable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8413"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2202"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8413"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8413"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8413"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}