{"id":8452,"date":"2021-12-16T13:30:19","date_gmt":"2021-12-16T18:30:19","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/vysoce-kvalitni-atosiban-cas-90779-69-4-je-kombinovany-antagonista-kontrakcniho-a-presinoveho-receptoru-v1a\/"},"modified":"2021-12-16T13:30:19","modified_gmt":"2021-12-16T18:30:19","slug":"vysoce-kvalitni-atosiban-cas-90779-69-4-je-kombinovany-antagonista-kontrakcniho-a-presinoveho-receptoru-v1a","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/vysoce-kvalitni-atosiban-cas-90779-69-4-je-kombinovany-antagonista-kontrakcniho-a-presinoveho-receptoru-v1a\/","title":{"rendered":"Vysoce kvalitn\u00ed Atosiban CAS 90779-69-4 je kombinovan\u00fd antagonista kontrak\u010dn\u00edho a presinov\u00e9ho receptoru V1A"},"content":{"rendered":"

Vysoce kvalitn\u00ed Atosiban CAS 90779-69-4 je kombinovan\u00fd antagonista kontrak\u010dn\u00edho a presinov\u00e9ho receptoru V1A<\/strong><\/h2>\n

N\u00e1zev produktu: Atosiban
\nSynonyma: RW-22164;RW-22164;RWJ-22164;Atosiban Impurtiy;atosiban price;1-deamino-2d-tyr-(oet)-4-thr-8-orn- oxytocin;oxytocin,1-(3-merkaptopropanov\u00e1 kyselina)-2-(o-ethyl-d-tyrosin)-4-l-threonin-8-l;rwj22164;ATOSIBAN ACETATE
\nCAS: 90779-69-4<& >MF: C43H67N11O12S2
\nMW: 994,19
\nEINECS: 806-815-5
\nKategorie produkt\u016f: hormony;Peptid
\nMol Soubor: 90779-69-4.mol<\/p>\n

Atosiban byl zaveden ve Spojen\u00e9m kr\u00e1lovstv\u00ed jako injek\u010dn\u00ed inhibitor p\u0159ed\u010dasn\u00e9ho porodu, hlavn\u00ed p\u0159\u00ed\u010dina d\u011btsk\u00e9 morbidity a mortality. Tento peptidov\u00fd analog oxytocinu je antagonistou receptoru vasopresinu Vla a receptoru oxytocinu, kter\u00fd se nach\u00e1z\u00ed v dramaticky zv\u00fd\u0161en\u00e9 koncentraci v d\u011blo\u017en\u00edm myometriu t\u011bhotn\u00fdch \u017een t\u011bsn\u011b p\u0159ed porodem. Kompetitivn\u011b inhiboval kontrakce v d\u011bloze b\u0159ez\u00edho mor\u010dete vyvolan\u00e9 oxytocinem a vazopresinem. V multicentrick\u00e9, dvojit\u011b zaslepen\u00e9, placebem kontrolovan\u00e9 studii zp\u016fsobila l\u00e9\u010dba atosibanem prodlou\u017een\u00ed t\u011bhotenstv\u00ed a\u017e o 7 dn\u00ed u \u017een s v\u00edce ne\u017e 28. t\u00fddnem t\u011bhotenstv\u00ed. Ve srovn\u00e1vac\u00ed klinick\u00e9 studii vykazoval atosiban srovnateln\u00fd tokolytick\u00fd \u00fa\u010dinek (uterinn\u00ed relaxant) jako ritodrin, ale prvn\u00ed z nich byl v\u00fdznamn\u011b l\u00e9pe tolerov\u00e1n, zejm\u00e9na s ohledem na kardiovaskul\u00e1rn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky u matky. U zdrav\u00fdch dobrovoln\u00edk\u016f se plazmatick\u00e9 hladiny atosibanu sni\u017eovaly bi-exponenci\u00e1ln\u011b s po\u010d\u00e1te\u010dn\u00edm a termin\u00e1ln\u00edm polo\u010dasem 21 minut a 1,7 h.<\/p>\n

Atosiban je kombinovan\u00fd antagonista receptoru kontraktinu a presinu V1A. Struktura receptoru pro kontraktin a receptoru presinu V1A je podobn\u00e1. Kdy\u017e je receptor kontraktiln\u00edho hormonu zablokov\u00e1n, kontraktiln\u00ed hormon m\u016f\u017ee st\u00e1le p\u016fsobit prost\u0159ednictv\u00edm receptoru V1A, tak\u017ee je nutn\u00e9 blokovat v\u00fd\u0161e uveden\u00e9 dv\u011b cesty p\u016fsoben\u00ed receptoru, kdy\u017e se pou\u017e\u00edv\u00e1 stejn\u00e1 Chemicalbook, a jedin\u00fd antagonismus jednoho receptoru m\u016f\u017ee \u00fa\u010dinn\u011b inhibovat kontrakci d\u011blohy. To je jeden z hlavn\u00edch d\u016fvod\u016f, pro\u010d beta-agonist\u00e9, blok\u00e1tory v\u00e1pn\u00edkov\u00fdch kan\u00e1l\u016f a inhibitory prostaglandin synt\u00e1zy \u00fa\u010dinn\u011b neinhibuj\u00ed d\u011blo\u017en\u00ed kontrakce.<\/p>\n

Atosiban CAS 90779-69-4 Chemick\u00e9 vlastnosti<\/strong>
\nBod varu 1469,0\u00b165,0 \u00b0C (P\u0159edpokl\u00e1dan\u00e1)
\nhustota 1,254\u00b10,06 g\/cm3 (P\u0159edpokl\u00e1dan\u00e1)
\ntepl. -20\u00b0C
\nrozpustnost H2O: \u2264100 mg\/ml
\nforma pevn\u00e1 l\u00e1tka
\npka 12,81\u00b10,70(p\u0159edpoklad)
\nCAS DataBase Reference 90779-69-4(CAS DataBase Reference)
\n< &> Funkce a aplikace Atosibanu CAS 90779-69-4<\/strong>
\n1. P\u0159ed\u010dasn\u00fd porod
\n2. Atosiban je \u010dinidlo blokuj\u00edc\u00ed oxytocinov\u00fd receptor p\u0159i l\u00e9\u010db\u011b experiment\u00e1ln\u00ed endometri\u00f3zy a bylo prok\u00e1z\u00e1no, \u017ee vykazuje v\u00fdznamnou terapeutickou \u00fa\u010dinnost.<\/p>\n

Atosiban Anticancer Research Protin\u00e1dorov\u00e9 \u00fa\u010dinky esenci\u00e1ln\u00edho oleje O. falcata byly testov\u00e1ny u transplantovan\u00fdch my\u0161\u00edch pevn\u00fdch n\u00e1dor\u016f H22 in vivo . Inhibice r\u016fstu u solidn\u00edch n\u00e1dor\u016f H22 byla st\u0159edn\u00ed (Yang et al. 2013).<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Atosiban
\nCAS: 90779-69-4
\nMF: C43H67N11O12S2
\nMW: 994,19
\nEINECS: 806-815-5
\nMol Soubor: 90779-69-4.mol<\/p>\n","protected":false},"featured_media":2118,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[432],"product_tag":[1217],"class_list":{"0":"post-8452","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-urogenitalni-peptid","7":"product_tag-high-quality-atosiban-cas-90779-69-4-is-a-combined-contractin-and-pressin-v1a-receptor-antagonist-cs","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8452"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2118"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8452"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8452"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8452"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}