{"id":8569,"date":"2021-12-17T01:47:29","date_gmt":"2021-12-17T06:47:29","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/nesiritid-bnp-32-human-cas-124584-08-3-mozkovy-natriureticky-peptid-pro-srdecni-selhani\/"},"modified":"2021-12-17T01:47:29","modified_gmt":"2021-12-17T06:47:29","slug":"nesiritid-bnp-32-human-cas-124584-08-3-mozkovy-natriureticky-peptid-pro-srdecni-selhani","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/nesiritid-bnp-32-human-cas-124584-08-3-mozkovy-natriureticky-peptid-pro-srdecni-selhani\/","title":{"rendered":"Nesiritid \/ BNP-32 (HUMAN) CAS 124584-08-3 Mozkov\u00fd natriuretick\u00fd peptid pro srde\u010dn\u00ed selh\u00e1n\u00ed"},"content":{"rendered":"

Nesiritid \/ BNP-32 (HUMAN) CAS 124584-08-3 Mozkov\u00fd natriuretick\u00fd peptid pro srde\u010dn\u00ed selh\u00e1n\u00ed<\/strong><\/h2>\n

N\u00e1zev produktu: Nesiritide \/ BNP-32 (HUMAN)
\nSynonyma: Nesiritid,Brain Natriuretic Peptide-32 \u010dlov\u011bk,BNP-32, >98%;BNP-32 (lidsk\u00fd) hydrochlorid;Nesiritid [USAN:INN] ;SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (DISULFIDOV\u00dd MOST: 10-26);SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER -SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS;H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY -ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH;H-SER-PRO-LYS -MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL -LEU-ARG-ARG-HIS-OH (DISULFIDOV\u00dd MOST: 10-26);BRAIN NATRIURETICK\u00dd PEPTID (1-32), LIDSK\u00dd
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nKategorie produkt\u016f:
\nMol File: 124584-08-3.mol<\/p>\n

Nesiritid byl zaveden v USA jako nov\u00e1 intraven\u00f3zn\u00ed l\u00e9\u010dba pro pacienty s akutn\u011b dekompenzovan\u00e9 m\u011bstnav\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed, kte\u0159\u00ed maj\u00ed du\u0161nost v klidu nebo s minim\u00e1ln\u00ed aktivitou ity. Nesiritid je prvn\u00ed lidsk\u00e1 rekombinantn\u00ed forma siln\u00e9ho vazodilata\u010dn\u00edho natriuretick\u00e9ho peptidu typu B (tak\u00e9 zn\u00e1m\u00e9ho jako mozkov\u00fd natriuretick\u00fd peptid), p\u0159irozen\u011b se vyskytuj\u00edc\u00edho peptidu o 32 aminokyselin\u00e1ch se strukturou kruhu o 17 aminokyselin\u00e1ch v\u00e1zanou disulfidovou vazbou. Nesiritid se v\u00e1\u017ee na receptor natriuretick\u00e9ho peptidu Atype na povrchu endoteli\u00e1ln\u00edch bun\u011bk a bun\u011bk hladk\u00e9ho svalstva, \u010d\u00edm\u017e stimuluje produkci druh\u00e9ho posla cGMP, kter\u00fd zprost\u0159edkov\u00e1v\u00e1 p\u0159ev\u00e1\u017en\u011b relaxaci bun\u011bk hladk\u00e9ho svalstva c\u00e9v. Usnad\u0148uje tak\u00e9 vylu\u010dov\u00e1n\u00ed sod\u00edku a vody ledvinami a sni\u017euje sekreci n\u011bkter\u00fdch hormon\u016f, jako je adrenalin, angiotensin II, aldosteron a endotelin, kter\u00e9 vyvol\u00e1vaj\u00ed dlouhodob\u00e9 \u0161kodliv\u00e9 \u00fa\u010dinky v\u010detn\u011b konstrikce krevn\u00edch c\u00e9v a zv\u00fd\u0161en\u00ed krevn\u00edho tlaku. V klinick\u00fdch studi\u00edch s pacienty se srde\u010dn\u00edm selh\u00e1n\u00edm nesidtid v z\u00e1vislosti na d\u00e1vce sni\u017eoval tlak v plicn\u00edch kapil\u00e1r\u00e1ch, tlak v prav\u00e9 s\u00edni a syst\u00e9movou vaskul\u00e1rn\u00ed rezistenci a zvy\u0161oval srde\u010dn\u00ed index bez ovlivn\u011bn\u00ed srde\u010dn\u00ed frekvence. Hlavn\u00edm pozorovan\u00fdm ne\u017e\u00e1douc\u00edm \u00fa\u010dinkem byla hypotenze z\u00e1visl\u00e1 na d\u00e1vce. Ve srovn\u00e1vac\u00ed studii f\u00e1ze III bylo zji\u0161t\u011bno, \u017ee nesiritid je lep\u0161\u00ed ne\u017e iv. nitroglycerin v jeho hemodynamick\u00fdch \u00fa\u010dinc\u00edch, stejn\u011b jako snadn\u011bj\u0161\u00ed pod\u00e1v\u00e1n\u00ed a lep\u0161\u00ed sn\u00e1\u0161enlivost. Nesiritid je odstra\u0148ov\u00e1n proteolytick\u00fdm \u0161t\u011bpen\u00edm enzymem neutr\u00e1ln\u00ed endopeptid\u00e1zou NEP24.11 a vazbou na natriuretick\u00fd peptidov\u00fd receptor typu C s n\u00e1slednou endocyt\u00f3zou a intracelul\u00e1rn\u00ed lysozom\u00e1ln\u00ed hydrol\u00fdzou. Proto\u017ee m\u00e1 kr\u00e1tk\u00fd polo\u010das (18 minut), nesiritid se pod\u00e1v\u00e1 jako bolusov\u00e1 infuze 21 \u03bcg\/kg, po n\u00ed\u017e n\u00e1sleduje kontinu\u00e1ln\u00ed udr\u017eovac\u00ed infuze rychlost\u00ed 0,011 \u03bcg\/kg\/min obvykle po dobu 24\u201348 hodin.<\/p>\n

Nesiritid \/ BNP-32 (HUMAN) CAS 124584-08-3 Chemick\u00e9 vlastnosti<\/strong>
\nBNP-32 (HUMAN) Chemick\u00e9 vlastnosti
\nhustota 1,52\u00b10,1 g\/cm3 (p\u0159edpoklad)
\nRTECS EE1534000
\ntepl. \u221220\u00b0C
\nforma pr\u00e1\u0161ku
\nRozpustnost ve vod\u011b Rozpustn\u00e1 ve vod\u011b p\u0159i 1 mg\/ml
\nCAS DataBase Reference 124584-08-3<\/p>\n

Funkce a aplikace Nesiritidu \/ BNP-32 (HUMAN) CAS 124584-08-3<\/strong>
\nL\u00e9\u010dba m\u011bstnav\u00e9ho srde\u010dn\u00edho selh\u00e1n\u00ed (antagonista renin-angiotenzinov\u00e9ho syst\u00e9mu).<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Nesiritide \/ BNP-32 (HUMAN)
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464,04
\nEINECS: 1312995-182-4
\nKategorie produktu
\nKategorie produktu &>Soubor Mol: 124584-08-3.mol<\/p>\n","protected":false},"featured_media":2286,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[491],"product_tag":[1129],"class_list":{"0":"post-8569","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptid-kardiovaskularniho-systemu","7":"product_tag-nesiritide-bnp-32-human-cas-124584-08-3-brain-natriuretic-peptide-for-heart-failure-cs","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8569"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2286"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8569"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8569"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8569"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}