{"id":8635,"date":"2021-12-17T01:50:43","date_gmt":"2021-12-17T06:50:43","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/glucagon-cas-16941-32-5-podporuje-glykogenolyzu-a-produkci-glukozy-ke-zvyseni-hladiny-cukru-v-krvi\/"},"modified":"2021-12-17T01:50:43","modified_gmt":"2021-12-17T06:50:43","slug":"glucagon-cas-16941-32-5-podporuje-glykogenolyzu-a-produkci-glukozy-ke-zvyseni-hladiny-cukru-v-krvi","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/glucagon-cas-16941-32-5-podporuje-glykogenolyzu-a-produkci-glukozy-ke-zvyseni-hladiny-cukru-v-krvi\/","title":{"rendered":"Glucagon CAS 16941-32-5 Podporuje glykogenol\u00fdzu a produkci gluk\u00f3zy ke zv\u00fd\u0161en\u00ed hladiny cukru v krvi"},"content":{"rendered":"

Glucagon CAS 16941-32-5 Podporuje glykogenol\u00fdzu a produkci gluk\u00f3zy ke zv\u00fd\u0161en\u00ed hladiny cukru v krvi<\/strong><\/h2>\n

N\u00e1zev produktu: Glukagon
\nSynonyma: GLUKAGON 1-37;GLUKAGON (1-37) (PORCINE);GLUKAGON 37;GLUKAGON ACETATE;HSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIA;H-HIS-SER-GLRN-PHEGLY -SER-ASP-TYR-SER-LYS-TYR-LEU-ASP-SER-ARG-ARG-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-LYS-ARG-ASN -LYS-ASN-ASN-ILE-ALA-OH;Glukagon 1-29;Glukagon(1-29) Lidsk\u00e1 HCl
\nCAS: 16941-32-5
\nMF: C153H225N43O49S
\n MW: 3482,75<& >EINECS: 685-611-6
\nKategorie produkt\u016f: Aminokyselinov\u00e9 deriv\u00e1ty;Peptid;Glukagon Biologie kmenov\u00fdch bun\u011bk ostr\u016fvk\u016f;Diferenciace kmenov\u00fdch bun\u011bk ostr\u016fvk\u016f;Hormony;Hormony jin\u00fdch protein\u016f\/peptid\u016f;Glukagon a glukagonov\u00e9 peptidy podobn\u00e9 glukagonov\u00fdm bun\u011b\u010dn\u00fdm peptid\u016fm pro biologii bun\u011bk Glukagonu GlukagonuP Bun\u011b\u010dn\u00e1 biologie;Cytokinov\u00e9 r\u016fstov\u00e9 faktory a hormony (obezita);Gastrointestin\u00e1ln\u00ed peptidy;V\u00fdzkum glukagonov\u00e9 obezity;API;V\u00fdzkum diabetu
\nMol File: 16941-32-5.mol<\/p>\n

Glukagon, tak\u00e9 zn\u00e1m\u00fd jako glukagon, je polypeptidov\u00fd hormon s p\u0159\u00edm\u00fdm \u0159et\u011bzcem vylu\u010dovan\u00fd \u03b1 bu\u0148kami pankreatick\u00fdch ostr\u016fvk\u016f, obsahuj\u00edc\u00ed 29 aminokyselin, s molekul\u00e1rn\u00edm vzorcem a relativn\u00ed molekul\u00e1rn\u00ed hmotnost C153H225N43O49S = 3482,8. \u010c\u00edna tento hormon syntetizovala. Je to druh b\u00edl\u00e9ho jemn\u00e9ho krystalick\u00e9ho pr\u00e1\u0161ku bez z\u00e1pachu a chuti p\u0159i pokojov\u00e9 teplot\u011b. Glukagon je t\u00e9m\u011b\u0159 nerozpustn\u00fd ve vod\u011b a v\u011bt\u0161in\u011b organick\u00fdch rozpou\u0161t\u011bdel, zat\u00edmco je rozpustn\u00fd ve z\u0159ed\u011bn\u00e9 kyselin\u011b a z\u0159ed\u011bn\u00e9m alkalick\u00e9m roztoku. V\u011bt\u0161ina p\u0159\u00edpravku je hydrochlorid, kter\u00fd je rozpu\u0161t\u011bn ve vod\u011b. Je zn\u00e1mo, \u017ee glukagon si mus\u00ed zachovat svou molekul\u00e1rn\u00ed integritu, aby mohl uplatnit svou fyziologickou aktivitu. Struktura glukagonu \u010dlov\u011bka a savce (kr\u00e1l\u00edk, skot, prase, krysa atd.) m\u016f\u017ee b\u00fdt konzistentn\u00ed, zat\u00edmco u pt\u00e1k\u016f se mohou m\u00edrn\u011b li\u0161it.<\/p>\n

Glukagon je polypeptid sest\u00e1vaj\u00edc\u00ed z 29 aminokyselin a je vylu\u010dov\u00e1n alfa bu\u0148kami ostr\u016fvk\u016f slinivky b\u0159i\u0161n\u00ed. Glukagon se vyr\u00e1b\u00ed z pro-glukagonov\u00e9ho genu, zpo\u010d\u00e1tku jako prekurzor pro-glukagonu, kter\u00fd je tk\u00e1\u0148ov\u011b specifick\u00fd v alfa bu\u0148k\u00e1ch slinivky b\u0159i\u0161n\u00ed za vzniku glukagonu a ve st\u0159evn\u00edch bu\u0148k\u00e1ch na GLP-1 a GLP-2.
\n<& >Obecn\u011b se uzn\u00e1v\u00e1, \u017ee inzulin a glukagon jsou hlavn\u00edmi hormony zapojen\u00fdmi do patofyziologie diabetu, ale role glukagonu u diabetu je v n\u011bkter\u00fdch p\u0159\u00edpadech komplexn\u00ed a kontroverzn\u00ed. Role glukagonu v aktu\u00e1ln\u011b pou\u017e\u00edvan\u00fdch hypoglykemick\u00fdch l\u00e1tk\u00e1ch je v\u011bnov\u00e1na st\u00e1le v\u011bt\u0161\u00ed pozornost a pokra\u010duj\u00edc\u00ed v\u00fdvoj c\u00edlen\u00e9 terapie glukagonem zd\u016fraz\u0148uje d\u016fle\u017eit\u00fd p\u0159\u00ednos glukagonu p\u0159i optimalizaci l\u00e9\u010dby diabetu.<\/p>\n

Glukagon je kontraregula\u010dn\u00ed hormon, kter\u00fd stimuluje gluk\u00f3zu v j\u00e1trech produkci, aby se zabr\u00e1nilo hypoglyk\u00e9mii. Glukagonov\u00e9 receptory se nach\u00e1zej\u00ed na hepatocytech a vazebn\u00e1 m\u00edsta pro glukagon byla tak\u00e9 identifikov\u00e1na v ledvin\u00e1ch, srdci, gastrointestin\u00e1ln\u00edm traktu, tukov\u00e9 tk\u00e1ni, mozku a slezin\u011b. Na z\u00e1klad\u011b studi\u00ed na psech je p\u0159ibli\u017en\u011b 17 % glukagonu odbour\u00e1v\u00e1no ledvinami a 20 % a\u017e 25 % je odbour\u00e1v\u00e1no v j\u00e1trech. Uvol\u0148ov\u00e1n\u00ed glukagonu v reakci na hypoglyk\u00e9mii bylo dob\u0159e prok\u00e1z\u00e1no a je zprost\u0159edkov\u00e1no autonomn\u00edmi, endokrinn\u00edmi a parakrinn\u00edmi mechanismy a mo\u017en\u00e1 tak\u00e9 p\u0159\u00edm\u00fdm sn\u00edm\u00e1n\u00edm hladiny gluk\u00f3zy v krvi alfa bu\u0148kami. P\u0159esn\u00e9 molekul\u00e1rn\u00ed mechanismy, kter\u00fdmi bu\u0148ky vylu\u010duj\u00ed glukagon, nejsou pln\u011b zn\u00e1my, ale zahrnuj\u00ed kan\u00e1ly adenosintrifosf\u00e1tu draseln\u00e9ho (KATP) a v\u00e1pn\u00edkov\u00e9 kan\u00e1ly.<\/p>\n

V norm\u00e1ln\u00ed fyziologii je sekrece glukagonu b\u011bhem hyperglyk\u00e9mie inhibov\u00e1na produkty bun\u011b\u010dn\u00e9 sekrece inzul\u00ednem, zinek a kyselina gama-aminom\u00e1seln\u00e1 (GABA), kter\u00e9 se uvol\u0148uj\u00ed v reakci na j\u00eddlo a zv\u00fd\u0161enou hladinu gluk\u00f3zy v krvi. Kdy\u017e hladina gluk\u00f3zy v krvi kles\u00e1, beta bu\u0148ky sni\u017euj\u00ed produkci t\u011bchto produkt\u016f, \u010d\u00edm\u017e eliminuj\u00ed jejich inhibi\u010dn\u00ed \u00fa\u010dinek na alfa bu\u0148ky. Tento mechanismus, zn\u00e1m\u00fd jako hypot\u00e9za \u201evypnut\u00ed\u201c, nakonec vede ke zv\u00fd\u0161en\u00ed sekrece glukagonu, kdy\u017e je hladina gluk\u00f3zy v krvi p\u0159\u00edli\u0161 n\u00edzk\u00e1. R\u016fstov\u00fd inhibi\u010dn\u00ed hormon, kter\u00fd je produkov\u00e1n \u03b4 bu\u0148kami a GLP-1 v ostr\u016fvc\u00edch, tak\u00e9 inhibuje sekreci glukagonu.<\/p>\n

Jak u diabetes mellitus 1. typu (T1DM), tak u diabetes mellitus 2. typu (T2DM), hladiny glukagonu v plazm\u011b jsou p\u0159\u00edli\u0161 vysok\u00e9. Glukagon, regula\u010dn\u00ed hormon, kter\u00fd podporuje produkci gluk\u00f3zy v j\u00e1trech, zabra\u0148uje hypoglyk\u00e9mii za norm\u00e1ln\u00edch fyziologick\u00fdch podm\u00ednek. U pacient\u016f s diabetem m\u016f\u017ee b\u00fdt sekrece glukagonu nekontrolovan\u00e1, co\u017e vede k probl\u00e9m\u016fm s homeost\u00e1zou gluk\u00f3zy. N\u011bkter\u00e9 zp\u016fsoby l\u00e9\u010dby diabetu jsou \u00fa\u010dinn\u00e9 t\u00edm, \u017ee inhibuj\u00ed sekreci nebo p\u016fsoben\u00ed glukagonu, stejn\u011b jako glukagonov\u011b specifick\u00e1 c\u00edlen\u00e1 terapie.<\/p>\n

Glucagon CAS 16941-32-5 Chemick\u00e9 vlastnosti<\/strong>
\nhustota 1,53\u00b10,1 g\/cm3( P\u0159edpokl\u00e1dan\u00e1)
\ntepl. Uchov\u00e1vejte na tmav\u00e9m m\u00edst\u011b, zape\u010det\u011bno v suchu, 2-8\u00b0C
\nrozpustnost Prakticky nerozpustn\u00fd ve vod\u011b a ve v\u011bt\u0161in\u011b organick\u00fdch rozpou\u0161t\u011bdel. Je rozpustn\u00fd ve z\u0159ed\u011bn\u00fdch miner\u00e1ln\u00edch kyselin\u00e1ch a ve z\u0159ed\u011bn\u00fdch roztoc\u00edch alkalick\u00fdch hydroxid\u016f.
\nforma pr\u00e1\u0161ku<\/p>\n

Funkce a pou\u017eit\u00ed glukagonu CAS 16941-32-5<\/strong>
\n1\u3001Zv\u00fd\u0161en\u00ed \u00fa\u010dinku gluk\u00f3zy v krvi: M\u016f\u017ee aktivovat jatern\u00ed fosforyl\u00e1zy, podporuj\u00ed rozklad jatern\u00edho glykogenu a izogenezi glykogenu a zvy\u0161uj\u00ed hladinu gluk\u00f3zy v krvi.
\n2\u3001Pozitivn\u00ed inotropn\u00ed \u00fa\u010dinek: M\u016f\u017ee zv\u00fd\u0161it intracelul\u00e1rn\u00ed obsah cAMP, zv\u00fd\u0161it kontraktilitu myokardu, zv\u00fd\u0161it srde\u010dn\u00ed v\u00fddej a pracovat na jeden \u00fader. Jeho pozitivn\u011b inotropn\u00ed \u00fa\u010dinek se m\u016f\u017ee uplatnit i po aplikaci dostate\u010dn\u00e9ho mno\u017estv\u00ed srde\u010dn\u00edho glykosidu a nen\u00ed blokov\u00e1n propranololem. P\u0159esto\u017ee m\u016f\u017ee zv\u00fd\u0161it srde\u010dn\u00ed frekvenci a krevn\u00ed tlak, nezp\u016fsobuje arytmii. Mechanismy jsou: (1) aktivace adenyl\u00e1tcykl\u00e1zy k p\u0159em\u011bn\u011b adenosintrifosf\u00e1tu na cyklizovan\u00fd adenosinmonofosf\u00e1t, kter\u00fd zvy\u0161uje kontraktilitu myokardu; (2) podpora jatern\u00ed glykogenol\u00fdzy a zv\u00fd\u0161en\u00ed hladiny gluk\u00f3zy v krvi; (3) podpora uvol\u0148ov\u00e1n\u00ed inzul\u00ednu uvol\u0148ov\u00e1n\u00ed podle chemick\u00e9 knihy, zlep\u0161en\u00ed vyu\u017eit\u00ed gluk\u00f3zy v myokardu a podpora myokardi\u00e1ln\u00edch anaerobn\u00edch enzym\u016f, \u010d\u00edm\u017e se zlep\u0161\u00ed energetick\u00fd metabolismus myokardu. V kombinaci se srde\u010dn\u00edmi glykosidy podobn\u00fdmi digitalisu m\u016f\u017ee zv\u00fd\u0161it \u00fa\u010dinnost.
\n3. \u00da\u010dinky na ledviny: dilatuj\u00ed ledvinov\u00e9 krevn\u00ed c\u00e9vy, zlep\u0161uj\u00ed pr\u016ftok krve ledvinami a podporuj\u00ed vylu\u010dov\u00e1n\u00ed sod\u00edku, drasl\u00edku a v\u00e1pn\u00edku.
\n4. \u00da\u010dinky na tr\u00e1vic\u00ed syst\u00e9m: m\u016f\u017ee zp\u016fsobit relaxaci hladk\u00e9ho svalstva \u017ealudku a dvan\u00e1ctn\u00edku, tenk\u00e9ho st\u0159eva a tlust\u00e9ho st\u0159eva, inhibovat peristaltiku \u017ealudku, tenk\u00e9ho st\u0159eva a tlust\u00e9ho st\u0159eva a zv\u00fd\u0161it sekreci \u017elu\u010di a st\u0159evn\u00ed tekutiny.
\n5. \u00da\u010dinky na sekre\u010dn\u00ed syst\u00e9m: excituje d\u0159e\u0148 nadledvin, podporuje uvol\u0148ov\u00e1n\u00ed katecholamin\u016f. M\u016f\u017ee tak\u00e9 podporovat sekreci inzulinu, hormonu \u0161t\u00edtn\u00e9 \u017el\u00e1zy, kalcitoninu a r\u016fstov\u00e9ho hormonu.<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Glucagon
\nCAS: 16941-32-5
\nMF: C153H225N43O49S
\nMW: 3482,75
\nEINECS: 685-611-6
\nMol Soubor: 16941-32-5.mol<\/p>\n","protected":false},"featured_media":2118,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[339],"product_tag":[1085],"class_list":{"0":"post-8635","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptid-diabetu","7":"product_tag-glucagon-cas-16941-32-5-promotes-glycogenolysis-and-glucose-production-to-raise-blood-sugar-cs","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8635","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8635"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2118"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8635"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8635"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8635"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8635"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}