{"id":8715,"date":"2021-12-17T03:00:43","date_gmt":"2021-12-17T08:00:43","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/ganirelix-acetate-cas-123246-29-7-antagoniste-hormonu-uvolnujiciho-gonadotropin-gnrh\/"},"modified":"2021-12-17T03:00:43","modified_gmt":"2021-12-17T08:00:43","slug":"ganirelix-acetate-cas-123246-29-7-antagoniste-hormonu-uvolnujiciho-gonadotropin-gnrh","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/ganirelix-acetate-cas-123246-29-7-antagoniste-hormonu-uvolnujiciho-gonadotropin-gnrh\/","title":{"rendered":"Ganirelix Acetate CAS 123246-29-7 Antagonist\u00e9 hormonu uvol\u0148uj\u00edc\u00edho gonadotropin (GnRH)"},"content":{"rendered":"<h2><strong>Ganirelix Acetate CAS 123246-29-7 Antagonist\u00e9 hormonu uvol\u0148uj\u00edc\u00edho gonadotropin (GnRH)<\/strong><\/h2>\n<p>N\u00e1zev produktu: Ganirelix Acetate<br \/>\nSynonyma: Ac-DNal-DCpa-DPal-Ser-Tyr-DHar(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix acet\u00e1t;GANIRELIX; Ganirelix Acetate USP\/EP\/BP<br \/>\nCAS: 123246-29-7<br \/>\nMF: C80H113ClN18O13<br \/>\nMW: 1570,34<br \/>\nEINECS:<br \/>\nKategorie produkt\u016f: hormony<br \/>\nMol File: 1293246 -7.mol<\/p>\n<p>Ganirelix acet\u00e1t je syntetick\u00e1 dekapeptidov\u00e1 slou\u010denina podobn\u00e1 endogenn\u00edmu hormonu uvol\u0148uj\u00edc\u00edmu gonadotropin (GnRH) (tak\u00e9 zn\u00e1m\u00e9mu jako hormon uvol\u0148uj\u00edc\u00ed luteiniza\u010dn\u00ed hormon (LHRH)) a je antagonistou GnRH, kter\u00fd kompetitivn\u011b antagonizuje gonadotropn\u00ed receptor GnRH, \u010d\u00edm\u017e mutuje dr\u00e1hu a zp\u016fsobuje rychlou a reverzibiln\u00ed inhibici sekrece gonadotropinu (luteiniza\u010dn\u00ed hormon LH a folikuly stimuluj\u00edc\u00ed hormon FSH). Ganirelix acet\u00e1t inhibuje sekreci LH z hypof\u00fdzy v\u00fdrazn\u011bji ne\u017e sekreci FSH, \u010d\u00edm\u017e sni\u017euje produkci pohlavn\u00edch hormon\u016f.<\/p>\n<p> <strong>Funkce a aplikace Ganirelix acet\u00e1tu CAS 123246-29-7<\/strong><br \/>\nGanirelix acet\u00e1t je analogem GnRH se substitucemi ve zbytc\u00edch 1, 2, 3, 6, 8 a 10. Nen\u00ed to superagonista, ale sp\u00ed\u0161e syntetick\u00fd dekapeptid s vysokou antagonistickou aktivitou a prvn\u00ed antagonista GnRH, kter\u00fd byl uveden na trh. Je schv\u00e1len pro potla\u010den\u00ed n\u00e1r\u016fstu LH u \u017een, kter\u00e9 podstupuj\u00ed ovari\u00e1ln\u00ed hyperstimula\u010dn\u00ed l\u00e9\u010dbu plodnosti; N\u00e1r\u016fsty LH norm\u00e1ln\u011b podporuj\u00ed ovulaci. C\u00edlem tohoto l\u00e9ku je v\u00fdrazn\u011b sn\u00ed\u017eit po\u010det dn\u00ed medikace nezbytn\u00fdch k potla\u010den\u00ed n\u00e1r\u016fstu LH, a t\u00edm udr\u017eet vaj\u00ed\u010dka ve vaje\u010dn\u00edc\u00edch. L\u00e9\u010debn\u00e9 cykly in vitro fertilizace (IVF) byly historicky zah\u00e1jeny pod\u00e1v\u00e1n\u00edm leuprolidacet\u00e1tu k potla\u010den\u00ed p\u0159ed\u010dasn\u00e9ho uvol\u0148ov\u00e1n\u00ed LH. To inhibuje ovulaci, tak\u017ee vaj\u00ed\u010dka z\u016fst\u00e1vaj\u00ed k dispozici pro z\u00edsk\u00e1n\u00ed specialistou na plodnost. Za t\u00edmto \u00fa\u010delem se leuprolidacet\u00e1t obvykle aplikuje injek\u010dn\u011b po dobu a\u017e 26 dn\u016f. Klinick\u00e9 studie prok\u00e1zaly, \u017ee ganirelix acet\u00e1t dok\u00e1\u017ee zastavit n\u00e1r\u016fst LH za pouh\u00fdch 5 dn\u016f l\u00e9\u010dby, \u017ee potla\u010den\u00ed LH je v\u00fdrazn\u011bj\u0161\u00ed ne\u017e u FSH a \u017ee krat\u0161\u00ed doba l\u00e9\u010dby minimalizuje nep\u0159\u00edjemn\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky, jako jsou n\u00e1valy horka a bolesti hlavy. .<\/p>\n<p>Pou\u017e\u00edv\u00e1 se hlavn\u011b klinicky v protokolech kontrolovan\u00e9 stimulace vaje\u010dn\u00edk\u016f u \u017een podstupuj\u00edc\u00edch technologii asistovan\u00e9 reprodukce k prevenci p\u0159ed\u010dasn\u00fdch vrchol\u016f luteiniza\u010dn\u00edho hormonu a k l\u00e9\u010db\u011b poruch plodnosti zp\u016fsoben\u00fdch touto p\u0159\u00ed\u010dinou Chemicalbook. L\u00e9k m\u00e1 m\u00e9n\u011b ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f, vysokou m\u00edru t\u011bhotenstv\u00ed a kr\u00e1tk\u00e9 l\u00e9\u010debn\u00e9 cykly a m\u00e1 v\u00fdznamn\u00e9 klinick\u00e9 v\u00fdhody ve srovn\u00e1n\u00ed s podobn\u00fdmi l\u00e9ky.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>N\u00e1zev produktu: Ganirelix Acetate<br \/>\nCAS: 123246-29-7<br \/>\nMF: C80H113ClN18O13<br \/>\nMW: 1570,34<br \/>\nKategorie produkt\u016f: hormony<br \/>\nMol File: 123246-29-7.mol<\/p>\n","protected":false},"featured_media":2097,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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