{"id":8775,"date":"2021-12-17T03:04:37","date_gmt":"2021-12-17T08:04:37","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/vysoce-kvalitni-goserelin-acetat-cas-145781-92-6-pouzivany-k-lecbe-rakoviny-prsu\/"},"modified":"2021-12-17T03:04:37","modified_gmt":"2021-12-17T08:04:37","slug":"vysoce-kvalitni-goserelin-acetat-cas-145781-92-6-pouzivany-k-lecbe-rakoviny-prsu","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/vysoce-kvalitni-goserelin-acetat-cas-145781-92-6-pouzivany-k-lecbe-rakoviny-prsu\/","title":{"rendered":"Vysoce kvalitn\u00ed goserelin acet\u00e1t CAS 145781-92-6 pou\u017e\u00edvan\u00fd k l\u00e9\u010db\u011b rakoviny prsu"},"content":{"rendered":"

Vysoce kvalitn\u00ed goserelin acet\u00e1t CAS 145781-92-6 pou\u017e\u00edvan\u00fd k l\u00e9\u010db\u011b rakoviny prsu<\/strong><\/h2>\n

N\u00e1zev produktu: Goserelin acet\u00e1t
\nSynonyma: PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2;[(T-BU)DSER6, (AZA ( T-BU)-LEU-ARG-PRO-AZAGLY-NH2];1-9-Faktor uvol\u0148uj\u00edc\u00ed luteiniza\u010dn\u00ed hormon (prase), 6-(o-(1,1-dimethylethyl)-D-serin)-, 2- (aminokarbonyl)hydrazid, acet\u00e1t (s\u016fl);Fertilan;GLP-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZA-GLY-NH2
\nCAS: 145781-92-6
\nMF: C59H84N18O14
\nMW: 1269,41
\nEINECS: 652-995-1
\nKategorie produkt\u016f: Peptidy;Pepetidy; Deriv\u00e1ty aminokyselin; Meziprodukty a jemn\u00e9 chemik\u00e1lie; Peptidy:Pharmaceu Files 145781-92-6.mol<\/p>\n

Goserelinacet\u00e1t, stejn\u011b jako leuprolidacet\u00e1t, je syntetick\u00fd superagonistick\u00fd nonapeptidov\u00fd analog GnRH, kter\u00fd m\u00e1 v\u011bt\u0161\u00ed \u00fa\u010dinnost ne\u017e p\u0159irozen\u00fd hormon. V\u0161imn\u011bte si, \u017ee obsahuje D-Ser(But) a NH-NHCONH2 m\u00edsto Gly6 a Gly10-NH2, v dan\u00e9m po\u0159ad\u00ed. To znamen\u00e1, \u017ee C-termin\u00e1ln\u00ed modifikace m\u00e1 jednodu\u0161e NH nahrazuj\u00edc\u00ed CH2 Gly, a stejn\u011b jako C-termin\u00e1ln\u00ed zm\u011bna v leuprolidacet\u00e1tu inhibuje enzymatickou degradaci peptidu postprolinkarboxyamidpeptid\u00e1zou.
\nGoserelin acet\u00e1t je dostupn\u00fd v ve form\u011b mal\u00e9 pevn\u00e9 pelety, kter\u00e1 se pod\u00e1v\u00e1 jako SC implant\u00e1t pro paliativn\u00ed l\u00e9\u010dbu pokro\u010dil\u00e9ho metastatick\u00e9ho karcinomu prsu u pre- a perimenopauz\u00e1ln\u00edch \u017een nebo obdobn\u011b jako paliativn\u00ed prost\u0159edek u pokro\u010dil\u00e9ho karcinomu prostaty. D\u016fvodem pro pou\u017eit\u00ed tohoto l\u00e9ku je, jak je pops\u00e1no v\u00fd\u0161e, jeho schopnost jako superagonisty p\u0159iv\u00e9st hladiny estradiolu nebo testosteronu t\u00e9m\u011b\u0159 k kastra\u010dn\u00edm hladin\u00e1m, \u010d\u00edm\u017e se zpomal\u00ed progrese karcinomu prsu nebo prostaty. Nav\u00edc je goserelin acet\u00e1t schv\u00e1len pro pou\u017eit\u00ed p\u0159i l\u00e9\u010db\u011b endometri\u00f3zy po dobu a\u017e 6 m\u011bs\u00edc\u016f.<\/p>\n

Goserelin acet\u00e1t CAS 145781-92-6 Chemick\u00e9 vlastnosti<\/strong>
\nBod t\u00e1n\u00ed >190\u00b0C (rozkl.)
\nskladov\u00e1n\u00ed tepl. -20\u00b0C
\nrozpustnost H2O: 20 mg\/mL, \u010dir\u00fd, bezbarv\u00fd
\nforma b\u00edl\u00e9ho pr\u00e1\u0161ku
\nInChIKey IKDXDQDKCZPQSZ-JHYYTBFNSA-N
\nCAS DataBase Reference 145781-92-6<\/p>\n

Funkce a pou\u017eit\u00ed Goserelin acet\u00e1t CAS 145781-92-6<\/strong>
\n1. Protirakovinn\u00e9
\n2. injek\u010dn\u00ed superagonista hormonu uvol\u0148uj\u00edc\u00edho gonadotropin (agonista GnRH) nebo antiproliferativn\u00ed aktivita luteiniza\u010dn\u00edho hormonu u rakoviny prsu, prostaty a endometria
\n3. Syntetick\u00fd peptidov\u00fd agonistick\u00fd analog LH-RH. Antineoplastick\u00fd (hormon\u00e1ln\u00ed).<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Goserelin acet\u00e1t
\nCAS: 145781-92-6
\nMF: C59H84N18O14
\nMW: 1269,41
\nEINECS: 652-995-1
\nMol Soubor: 145781-92-6.mol<\/p>\n","protected":false},"featured_media":2202,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[397],"product_tag":[961],"class_list":{"0":"post-8775","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-protinadorovy-peptid","7":"product_tag-goserelin-acetate-cas-145781-92-6-used-for-treat-breast-cancer-cs","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8775","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8775"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2202"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8775"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8775"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8775"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8775"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}