{"id":8946,"date":"2021-12-17T03:39:56","date_gmt":"2021-12-17T08:39:56","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/linaclotide-cas-851199-59-2-pro-lecbu-syndromu-drazdiveho-tracniku-se-zacpou-ibs-c-a-chronicke-idiopaticke-zacpy-cic\/"},"modified":"2021-12-17T03:39:56","modified_gmt":"2021-12-17T08:39:56","slug":"linaclotide-cas-851199-59-2-pro-lecbu-syndromu-drazdiveho-tracniku-se-zacpou-ibs-c-a-chronicke-idiopaticke-zacpy-cic","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/cs\/product\/linaclotide-cas-851199-59-2-pro-lecbu-syndromu-drazdiveho-tracniku-se-zacpou-ibs-c-a-chronicke-idiopaticke-zacpy-cic\/","title":{"rendered":"Linaclotide CAS 851199-59-2 pro l\u00e9\u010dbu syndromu dr\u00e1\u017ediv\u00e9ho tra\u010dn\u00edku se z\u00e1cpou (IBS-C) a chronick\u00e9 idiopatick\u00e9 z\u00e1cpy (CIC)"},"content":{"rendered":"

Linaclotide CAS 851199-59-2 pro l\u00e9\u010dbu syndromu dr\u00e1\u017ediv\u00e9ho tra\u010dn\u00edku se z\u00e1cpou (IBS-C) a chronick\u00e9 idiopatick\u00e9 z\u00e1cpy (CIC)<\/strong><\/h2>\n

N\u00e1zev produktu: Linaclotide
\nSynonyma: Linaclotide; Linaclotide; Linaelotide acet\u00e1t; Linaelotide; CY-14; Liklotid; Argpessin; L-tyrosin, L-cysteinyl-L-cysteinyl-L-\u03b1-glutamyl-L-tyrosyl -L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyklick\u00fd (1\u21926),(2\u219210),(5\u2192 13)-tris(disulfid)
\nCAS: 851199-59-2
\nMF: C59H79N15O21S6
\nMW: 1526,74
\nEINECS:
\nKategorie produkt\u016f: Inhibitory
\nMol File: 85919 -2.mol<\/p>\n

Specifikace Linaclotidu<\/strong> <\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Obsah testov\u00e1n\u00ed<\/td>\n Specifikace<\/td>\n<\/tr>\n
Vzhled<\/td>\n B\u00edl\u00fd nebo t\u00e9m\u011b\u0159 b\u00edl\u00fd krystalick\u00fd pr\u00e1\u0161ek<\/td>\n<\/tr>\n
Identita pomoc\u00ed HPLC<\/td>\n Reakce je stejn\u00e1 jako u referen\u010dn\u00ed l\u00e1tky<\/td>\n<\/tr>\n
Aminokyselinov\u00e9 slo\u017een\u00ed<\/td>\n \u00b120 % teoretick\u00e9 hodnoty<\/td>\n<\/tr>\n
\u010cistota (HPLC)<\/td>\n \u2265 98,0 %<\/td>\n<\/tr>\n
P\u0159\u00edbuzn\u00e1 l\u00e1tka (pomoc\u00ed HPLC)<\/td>\n Celkov\u00e9 ne\u010distoty (%)\u2264 2,0 %
\nNejv\u011bt\u0161\u00ed jednotliv\u00e1 ne\u010distota (%)\u2264 1,0 %<\/td>\n<\/tr>\n
Obsah acet\u00e1tu (pomoc\u00ed HPLC)<\/td>\n \u2264 15 %<\/td>\n<\/tr>\n
Obsah vody (pomoc\u00ed HPLC)<\/td>\n \u2264 5,0 %<\/td>\n<\/tr>\n
Bakteri\u00e1ln\u00ed endotoxiny<\/td>\n \u22645 IU\/mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Funkce a aplikace Linaclotidu<\/strong>
\nLinaclotide je peptidov\u00fd agonista guanyl\u00e1tcykl\u00e1zy 2C.<\/p>\n

Tato slou\u010denina sni\u017euje aktivaci senzorick\u00fdch neuron\u016f tlust\u00e9ho st\u0159eva a sni\u017euje bolest; a aktivuje motorick\u00e9 neurony tlust\u00e9ho st\u0159eva, co\u017e zvy\u0161uje kontrakci hladk\u00e9ho svalstva a t\u00edm podporuje pohyby st\u0159ev.<\/p>\n

Byl schv\u00e1len FDA v srpnu 2012 pro l\u00e9\u010dbu chronick\u00e9 idiopatick\u00e9 z\u00e1cpy a syndromu dr\u00e1\u017ediv\u00e9ho tra\u010dn\u00edku s p\u0159evl\u00e1daj\u00edc\u00ed z\u00e1cpou (IBS-C ) u dosp\u011bl\u00fdch.<\/p>\n","protected":false},"excerpt":{"rendered":"

N\u00e1zev produktu: Linaclotide
\nCAS: 851199-59-2
\nMF: C59H79N15O21S6
\nMW: 1526,74
\nEINECS:
\nKategorie produkt\u016f: Inhibitory
\nMol File: 8511299-59 mol<\/p>\n","protected":false},"featured_media":2118,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[446],"product_tag":[],"class_list":{"0":"post-8946","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptid-gastrointestinalniho-systemu","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product\/8946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/comments?post=8946"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media\/2118"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/media?parent=8946"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_brand?post=8946"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_cat?post=8946"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/cs\/wp-json\/wp\/v2\/product_tag?post=8946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}