{"id":7258,"date":"2021-12-16T07:18:57","date_gmt":"2021-12-16T12:18:57","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv\/"},"modified":"2021-12-16T07:18:57","modified_gmt":"2021-12-16T12:18:57","slug":"enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/da\/product\/enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv\/","title":{"rendered":"Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 For Anti HIV"},"content":{"rendered":"

Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 For Anti HIV<\/strong><\/h2>\n

Produktnavn: Enfuvirtide
\nSekvens: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys< &>-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\nSynonymer: Enfuvirtide; T-2;Enfuvirtidacetat (T-20);ENFUVIRTIDE(T-20) 98+%;Enfurvitid(T-20);Pentafusid;Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH{2};Enfuvirtide;Aids059486
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-385-0< Produktkategorier< : proteiner;Peptid
\nMol Fil: 159519-65-0.mol<\/p>\n

Det er en syntetisk peptidh\u00e6mmer af HIV-fusion, som kan binde sig til det virale kappeglycoprotein og forhindre de konformationelle \u00e6ndringer, der er n\u00f8dvendige for virussen at fusionere med cellemembranen og dermed h\u00e6mme replikationen af HIV-1. Enfevir-peptid er afledt af en naturligt forekommende aminosyresekvens i HR2-dom\u00e6net af gp41. Ved at simulere aktiviteten af HR2-dom\u00e6net og kompetitivt binde til HR1-dom\u00e6net af gp41, forhindrer Enfevir-peptidet interaktionen mellem HR1 og HR2 og \u00e6ndringer i konfigurationen af Gp41, hvilket forhindrer fusionen af viruset med v\u00e6rtsceller.<\/p>\n

Enfuvirtide er den f\u00f8rste af en ny klasse af HIV-terapeutika, der interfererer med indtr\u00e6ngen af HIV-1 ved at h\u00e6mme fusion af virale og cellul\u00e6re membraner. Det binder til den f\u00f8rste heptad-repeat (HR1) i ghe gp41-underenhed af det virale kappe-glycoprotein og forhindrer de konformationelle \u00e6ndringer, der er n\u00f8dvendige for fusionen med cellemembraner, og repr\u00e6senterer s\u00e5ledes en ny mekanisme. Det er en potent h\u00e6mmer af denne binding med en IC50 i laboratorie- og prim\u00e6re isolater (HIV-1 clades A-G) i omr\u00e5det fra 4 til 280 nM (18-1260 ng\/mL), men har praktisk talt ingen aktivitet mod HIV-2. P\u00e5 grund af dens unikke mekanisme udviser den ikke krydsresistens over for NRTI, NNRTI og PI'er. Det fremstilles ved kemisk syntese ved hj\u00e6lp af en kombination af opl\u00f8snings- og fastfasetrin. Fastfasetrinene anvender fmoc-beskyttelse og den syref\u00f8lsomme 2-chlortritylchloridharpiks til at producere peptider med l\u00e6ngder fra ni til seksten aminosyrer. <\/p>\n

Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 Kemiske egenskaber<\/strong>
\nopbevaringstemp. -20\u00b0C
\nform pulver
\nfarve hvid til r\u00e5hvid<\/p>\n

Anvendelser af Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0<\/strong>
\nDet bruges i kombination med revers transkriptase-l\u00e6gemidler til mennesker immundefektvirus (HIV) infektion.<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnavn: Enfuvirtide
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-385-0
\nMol Fil: 159519-65-0.mol.<\/p>\n","protected":false},"featured_media":2119,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[531],"product_tag":[2496],"class_list":{"0":"post-7258","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-andre-peptider","7":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-da","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product\/7258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/comments?post=7258"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/media\/2119"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/media?parent=7258"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_brand?post=7258"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_cat?post=7258"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_tag?post=7258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}