{"id":8097,"date":"2021-12-16T12:17:40","date_gmt":"2021-12-16T17:17:40","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/ziconotide-acetate-cas-107452-89-1-behandling-til-postherpetisk-neuralgi-og-kraeftsmerter\/"},"modified":"2021-12-16T12:17:40","modified_gmt":"2021-12-16T17:17:40","slug":"ziconotide-acetate-cas-107452-89-1-behandling-til-postherpetisk-neuralgi-og-kraeftsmerter","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/da\/product\/ziconotide-acetate-cas-107452-89-1-behandling-til-postherpetisk-neuralgi-og-kraeftsmerter\/","title":{"rendered":"Ziconotide Acetate CAS 107452-89-1 Behandling til postherpetisk neuralgi og kr\u00e6ftsmerter"},"content":{"rendered":"

Ziconotide Acetate CAS 107452-89-1 Behandling til postherpetisk neuralgi og kr\u00e6ftsmerter<\/strong><\/h2>\n

Produktnavn: Ziconotide acetate
\nSynonymer: OMEGA-CONOTOXIN MVIIA;OMEGA-CGTX MVII A;ZICONOTIDE ACETATE;snx111;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG -LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS -SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDBRO: 1-16, 8-20 OG 15 -25);CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY- LYS-CYS-NH2;CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFID BRIDGE: 1-16,8-20, OG 15-25)
\nCAS: 107452-89-1
\nMF: C102H172N36<6O39W:36O32S:36O32S:36O32S: >EINECS:
\nProduktkategorier: Peptid
\nMol Fil: 107452-89-1.mol<\/p>\n

Ziconotid (Prialt) er en 25 aminosyrer, tre disulfidbundet peptidtoksinforbindelse, der stammer fra syden Stillehavshavssnegl Conusmagus. Det er det f\u00f8rste nye neuroterapeutiske middel – N-type calciumkanalblokker (NCCB). Det virker selektivt p\u00e5 N-type elektrosensitive Chemicalbook-calciumkanaler i dendritiske og axonale terminale grene og h\u00e6mmer derved initiale skadestimulus-afferenter. Det er indiceret til patienter med sv\u00e6re kroniske smerter, som kr\u00e6ver intratekal behandling, og som er intolerante over for eller har ringe effekt af andre analgetiske behandlinger (f.eks. p\u00e5f\u00f8ring af systemiske analgetika eller intrathekal morfin). Intrathecal ziconotid kan bruges til at behandle postherpetisk neuralgi, fantomsmerter i lemmer, HIV-relaterede neuropatiske smerter, refrakt\u00e6r cancersmerter og postkirurgiske smerter.<\/p>\n

Ziconotide Acetate CAS 107452-89-1 Kemiske egenskaber<\/strong>
\ndensitet 1,60\u00b10,1 g\/cm3(forudsagt)
\nopbevaringstemp. -20\u00b0C
\nInChIKey BPKIMPVREBSLAJ-QTBYCLKRSA-N<\/p>\n

Anvendelser af Ziconotide Acetate CAS 107452-89-1<\/strong>
\nLigand til bindingsunders\u00f8gelser af sp\u00e6ndingsf\u00f8lsomme calciumkanaler.<\/p>\n

Ziconotid ( SNX-111; Prialt), ogs\u00e5 kaldet intrathecal ziconotid (ITZ) p\u00e5 grund af dets administrationsvej, er et atypisk smertestillende middel til lindring af alvorlige og kroniske smerter. Afledt af Conus magus, en keglesnegl, er det den syntetiske form af et \u03c9-conotoxin-peptid.[1] Det er 1.000 gange s\u00e5 kraftfuldt som morphinie.<\/p>\n

Dette produkt er velegnet til patienter med sv\u00e6re kroniske smerter, som kr\u00e6ver intratekal behandling, og som er intolerante eller har ringe effekt over for andre smertestillende behandlinger (s\u00e5som anvendelse af systemiske analgetika eller intratekal injektion af morfin osv.).<\/p>\n

Funktion og anvendelse af ziconotidacetat CAS 107452-89-1<\/strong>
\n1. Analgetisk effekt Ziconotide er velegnet til patienter med kroniske smerter, som ikke kan tolerere eller ikke reagerer p\u00e5 andre behandlinger, herunder systemisk medicin, adjuverende behandling af intratekal injektion af morfin. Intratekal injektion af ziconotid har klinisk og statistisk signifikant analgetisk effekt hos patienter med cancer eller AIDS.<\/p>\n

2. Rygmarvsbeskyttelse Kortvarig rygmarvsisk\u00e6mi N\u00e5r rygmarvsneuroner er beskadiget, er der N-type elektrosensitiv calciumpathway-aktivering. Ziconotid kan give neurobeskyttelse og analgesi under aortakirurgi.<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnavn: Ziconotideacetat
\nCAS: 107452-89-1
\nMF: C102H172N36O32S7
\nMW: 2639.13
\nMol Fil: 107452-89-1.mol<\/p>\n","protected":false},"featured_media":2203,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[531],"product_tag":[1581],"class_list":{"0":"post-8097","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-andre-peptider","7":"product_tag-ziconotide-acetate-cas-107452-89-1-treat-for-postherpetic-neuralgia-and-cancer-pain-da","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product\/8097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/comments?post=8097"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/media\/2203"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/media?parent=8097"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_brand?post=8097"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_cat?post=8097"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_tag?post=8097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}