{"id":8368,"date":"2021-12-16T13:25:55","date_gmt":"2021-12-16T18:25:55","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/pramlintide-acetate-cas-196078-30-5-er-et-antidiabetisk-middel-der-ogsaa-kan-bruges-i-tarmkraeftforskning\/"},"modified":"2021-12-16T13:25:55","modified_gmt":"2021-12-16T18:25:55","slug":"pramlintide-acetate-cas-196078-30-5-er-et-antidiabetisk-middel-der-ogsaa-kan-bruges-i-tarmkraeftforskning","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/da\/product\/pramlintide-acetate-cas-196078-30-5-er-et-antidiabetisk-middel-der-ogsaa-kan-bruges-i-tarmkraeftforskning\/","title":{"rendered":"Pramlintide Acetate CAS 196078-30-5 er et antidiabetisk middel, der ogs\u00e5 kan bruges i tarmkr\u00e6ftforskning"},"content":{"rendered":"

Pramlintide Acetate CAS 196078-30-5 er et antidiabetisk middel, der ogs\u00e5 kan bruges i tarmkr\u00e6ftforskning<\/strong><\/h2>\n

Produktnavn: Pramlintideacetat
\nSynonymer: AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETAT (SALT), HYDRAT;pramlintideacetat; pramlintidacetathydrat ;25-L-prolin-28-L-prolin-29-L-prolin-aMylin (huMan) Acetathydrat;AC-137 Acetathydrat, SyMlin Acetathydrat;Tripo-aMylinacetathydrat;Pramlintideacetat, Amylinrotteacetat;Pramlintide fandachem
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027.46
\nEINECS:
\nProduktkategorier: Aminosyrer & derivater;Baser og relaterede reagenser;Drugetanaloger;Mellemiddelanaloger; & Finkemikalier;Nukleotider;Peptid;Pharmaceuticals
\nMol Fil: 196078-30-5.mol<\/p>\n

Pramlintideacetat er en injicerbar human amylinanalog, der er blevet lanceret til behandling af b\u00e5de type 1 og type 2 diabetes, i forbindelse med insulin. Selvom det ogs\u00e5 er et peptid p\u00e5 37 aminosyrer, adskiller det sig fra dets moderforg\u00e6nger ved at erstatte Ala-25, Ser-28 og Ser-29 med proliner. Ikke alene forbedrer disse modifikationer opl\u00f8seligheden af peptidet, de eliminerer ogs\u00e5 aggregeringen observeret med amylin, hvilket resulterer i en stabil syntetisk analog med bibeholdelse af biologisk aktivitet, der er egnet til farmaceutisk anvendelse. Som en indikation af styrke h\u00e6mmer Pramlintide-acetat bindingen af radioioderet rotteamylin til rotte nucleus accumbens-membraner med en Ki-v\u00e6rdi p\u00e5 23 pM. Dens virkningsmekanisme efterligner amylin; som et neurohormon, der udskilles sammen med insulin fra pancreas-\u03b2-cellerne som reaktion p\u00e5 m\u00e5ltider, er det involveret i glukose-homeostase. Begge peptider s\u00e6nker postprandiale glukoseniveauer ved at h\u00e6mme glucagon og ved at begr\u00e6nse den vagus-medierede hastighed af gastrisk t\u00f8mning, hvorved absorptionen af kulhydrat i tarmen s\u00e6nkes. Ydermere har amylin, eller Pramlintide-acetat, den ekstra fordel at inducere postprandial m\u00e6thed, hvilket resulterer i v\u00e6gttab hos patienter med type 2-diabetes. Da Pramlintideacetat forsinker mavet\u00f8mningen, er det kontraindiceret hos patienter med gastroparese og hos patienter, der tager medicin, der \u00e6ndrer gastrointestinal motilitet (antikolinerge midler, s\u00e5som atropin) eller forsinker tarmens absorption af n\u00e6ringsstoffer (s\u00e5som \u03b1-glucosidaseh\u00e6mmere). Pramlintideacetat er ogs\u00e5 kontraindiceret hos patienter med hypoglyk\u00e6miske tendenser; p\u00e5 grund af samtidig administration med insulin er alvorlig insulin-induceret hypoglyk\u00e6mi en risiko. De mest almindeligt rapporterede bivirkninger omfatter kvalme, opkastning, anoreksi, hovedpine, mavesmerter, tr\u00e6thed, svimmelhed, hoste og pharyngitis.<\/p>\n

Funktion og anvendelse af CAS 196078-30-5<\/strong> <\/p>\n

Pramlintide acetat er en syntetisk analog af pancreas amyloid polypeptid (Amylin, amylopectin) og er det andet l\u00e6gemiddel godkendt til behandling af type 1 diabetes efter insulin. I klinisk praksis anvendes pramlintid som et adjuverende l\u00e6gemiddel til behandling af type 1- og type 2-diabetes, hovedsageligt til patienter med diabetes, som ikke har opn\u00e5et de forventede resultater med insulin alene, og med kombinationen af insulin og sulfonylurinstoffer og metformin. Pramlintide kan bruges i kombination med insulin, men det kan ikke erstatte insulin.<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnavn: Pramlintideacetat
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027.46
\nMol Fil: 196078-30-5.mol<\/p>\n","protected":false},"featured_media":2203,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[338],"product_tag":[1282],"class_list":{"0":"post-8368","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-diabetes-peptid","7":"product_tag-pramlintide-acetate-cas-196078-30-5-is-an-antidiabetic-agent-that-can-also-be-used-in-bowel-cancer-research-da","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product\/8368","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/comments?post=8368"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/media\/2203"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/media?parent=8368"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_brand?post=8368"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_cat?post=8368"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_tag?post=8368"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}