{"id":8414,"date":"2021-12-16T13:28:05","date_gmt":"2021-12-16T18:28:05","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/hot-sale-farmaceutiske-peptider-pasireotid-cas-396091-73-9\/"},"modified":"2021-12-16T13:28:05","modified_gmt":"2021-12-16T18:28:05","slug":"hot-sale-farmaceutiske-peptider-pasireotid-cas-396091-73-9","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/da\/product\/hot-sale-farmaceutiske-peptider-pasireotid-cas-396091-73-9\/","title":{"rendered":"Hot Sale Farmaceutiske Peptider Pasireotid CAS 396091-73-9"},"content":{"rendered":"

Hot Sale Farmaceutiske Peptider Pasireotid CAS 396091-73-9<\/strong><\/h2>\n

Produktnavn: PASIREOTIDE
\nSynonymer: PASIREOTIDE;Cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-tyrosyl-L-phenylalanyl-(4R)- 4-[[[(2-aminoethyl)amino]carbonyl]oxy]-L-prolyl]; SOM 230; SOM 320; [(3S,6S,9S,12R,15S,18S,20R)-9-(4- aminobutyl)-3-benzyl-12-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-15-phenyl-6-[(4-phenylmethoxyphenyl)methyl]-1, 4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl]N-(2-aminoethyl)carbamat; SOM 230; SOM 320; CYCLO((4R)-4-(2-AMINOETHYLCARBAMOYLOXY) -L-PROLYL-L-PHENYLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-PHENYLALANYL-)
\nCAS: 396091-73-9
\nMF: C58H66N10O9<& >MW: 1047,23
\nEINECS:
\nProduktkategorier:
\nMol Fil: 396091-73-9.mol<\/p>\n

I april 2012 godkendte Europa-Kommissionen pasireotid til behandling af Cushings sygdom ( CD) hos voksne patienter, som ikke har reageret p\u00e5 kirurgisk indgreb, eller for hvem kirurgi ikke er valgfri. Pasireotid blev godkendt til samme indikation af US FDA i december 2012. Pasireotid (ogs\u00e5 k nun som SOM230) er et cyclohexapeptid, der fungerer som en somatostatinanalog til at h\u00e6mme frigivelsen af ACTH. Somatostatiner er cykliske peptider p\u00e5 14 og 28 aminosyrer, der spiller en vigtig rolle ved at regulere endokrin og exokrin frigivelse i mange v\u00e6v gennem en h\u00e6mmende mekanisme. Der er fem kendte undertyper af somatostatinreceptorer (SSTR'er). Naturlige somatostatiner binder med h\u00f8j affinitet til alle fem undertyper, men deres terapeutiske anvendelse er begr\u00e6nset af hurtig nedbrydning i plasma. Pasireotid opstod fra bestr\u00e6belser p\u00e5 at identificere et somatostatinmimetikum med langvarig h\u00e6mmende virkning. Startende med et somatostatinpeptid p\u00e5 14 aminosyrer afsl\u00f8rede en systematisk alanin-scanning rester, der var essentielle for binding af receptorsubtype, inklusive n\u00f8gleb-turn-regioner og tilst\u00f8dende rester. Placering af de vigtigste strukturelle elementer som unaturlige aminosyrer i en cyclohexapeptid-rygrad gav pasireotid.<\/p>\n

PASIREOTIDE CAS 396091-73-9<\/strong>
\nKogepunkt 1351,4\u00b165,0 \u00b0C(Forudsagt)
\ndensitet 1,36 \/cm3(Forudsagt)
\npka 11,86\u00b10,46(Forudsagt)
\nCAS DataBase Reference 396091-73-9<\/p>\n

Funktion og anvendelse af PASIREOTIDE CAS 396091-73-9<\/strong>
\nSom v\u00e6ksth\u00e6mmer analog, der binder til flere receptorer, pasireotid har vist sig at v\u00e6re mere effektiv end v\u00e6ksth\u00e6mmer-analoger s\u00e5som octreotid og lanreotid til behandling af akromegali, carcinoidtumorer og Cushings sygdom, b\u00e5de i pr\u00e6kliniske fors\u00f8g s\u00e5som cellul\u00e6re fors\u00f8g og dyrefors\u00f8g og i kliniske fors\u00f8g. Resultaterne af fase II-fors\u00f8g og et fase III-fors\u00f8g med pasireotid har bekr\u00e6ftet, at pasireotid er en ny behandling for nye eller vedvarende akromegali og metastatiske carcinoidtumorer, og kan v\u00e6re det f\u00f8rste valg af l\u00e6gemiddelbehandling for Cushings sygdom.<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnavn: PASIREOTIDE
\nMF: C58H66N10O9
\nMW: 1047.23
\nEINECS:
\nMol Fil: 396091-73-9.mol<\/p>\n","protected":false},"featured_media":2203,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[531],"product_tag":[1240],"class_list":{"0":"post-8414","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-andre-peptider","7":"product_tag-hot-sale-pharmaceutical-peptidespasireotide-cas-396091-73-9-da","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product\/8414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/comments?post=8414"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/media\/2203"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/media?parent=8414"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_brand?post=8414"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_cat?post=8414"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_tag?post=8414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}