{"id":8570,"date":"2021-12-17T01:47:29","date_gmt":"2021-12-17T06:47:29","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/nesiritide-bnp-32-human-cas-124584-08-3-natriuretisk-hjernepeptid-til-hjertesvigt\/"},"modified":"2021-12-17T01:47:29","modified_gmt":"2021-12-17T06:47:29","slug":"nesiritide-bnp-32-human-cas-124584-08-3-natriuretisk-hjernepeptid-til-hjertesvigt","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/da\/product\/nesiritide-bnp-32-human-cas-124584-08-3-natriuretisk-hjernepeptid-til-hjertesvigt\/","title":{"rendered":"Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Natriuretisk hjernepeptid til hjertesvigt"},"content":{"rendered":"

Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Natriuretisk hjernepeptid til hjertesvigt<\/strong><\/h2>\n

Produktnavn: Nesiritide \/ BNP-32 (HUMAN)
\nSynonymer: Nesiritide, Brain Natriuretic Peptide-32 human, BNP-32, >98%;BNP-32 (humant) hydrochlorid;Nesiritide [USAN:INN] ;SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (DISULFID BRO: 10-26);SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER -SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS;H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY -ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH;H-SER-PRO-LYS -MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL -LEU-ARG-ARG-HIS-OH (DISULFID BRO: 10-26); HJERNE NATRIURETISK PEPTID (1-32), HUMAN
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nProduktkategorier:
\nMol Fil: 124584-08-3.mol<\/p>\n

Nesiritide blev introduceret i USA som en ny intraven\u00f8s behandling til patienter med akut dekompenseret kongestiv hjerteinsufficiens, der har dyspn\u00f8 i hvile eller med minimal aktivitet ity. Nesiritide er den f\u00f8rste humane rekombinante form af det potente vasodilatoriske B-type natriuretiske peptid (ogs\u00e5 kendt som hjernenatriuretisk peptid), et naturligt forekommende 32 aminosyre peptid med en disulfidbundet 17 aminosyre ringstruktur. Nesiritid binder sig til den natriuretiske Atype-peptidreceptor p\u00e5 overfladen af endotelceller og glatte muskelceller, hvilket stimulerer produktionen af den anden messenger cGMP, som prim\u00e6rt medierer afslapning af vaskul\u00e6r glat muskelcelle. Det letter ogs\u00e5 elimineringen af natrium og vand fra nyrerne og reducerer sekretionen af visse hormoner, s\u00e5som adrenalin, angiotensin II, aldosteron og endotelin, som fremkalder langsigtede skadelige virkninger, herunder blodkarsammensn\u00e6vring og blodtryksforh\u00f8jelse. I kliniske fors\u00f8g med hjertesvigtpatienter reducerede nesidtid dosisafh\u00e6ngigt pulmon\u00e6rt kapill\u00e6rkiletryk, h\u00f8jre atrietryk og systemisk vaskul\u00e6r modstand og \u00f8gede hjerteindeks uden at p\u00e5virke hjertefrekvensen. Den st\u00f8rste observerede bivirkninger var dosisafh\u00e6ngig hypotension. I et fase III sammenlignende fors\u00f8g blev nesiritid fundet at v\u00e6re bedre end iv. nitroglycerin i sine h\u00e6modynamiske virkninger samt lettere at administrere og bedre tolereret. Nesiritid udskilles ved proteolytisk spaltning af enzymet neutral endopeptidase NEP24.11 og ved binding til C-type natriuretiske peptidreceptorer efterfulgt af endocytose og intracellul\u00e6r lysosomal hydrolyse. Da det har en kort halveringstid (18 min), administreres nesiritid som en 21\u03bcg\/kg bolusinfusion efterfulgt af en kontinuerlig vedligeholdelsesinfusion ved 0,011\u03bcg\/kg\/min, s\u00e6dvanligvis over 24-48 timer.<\/p>\n

Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Kemiske egenskaber<\/strong>
\nBNP-32 (HUMAN) Kemiske egenskaber
\ndensitet 1,52\u00b10,1 g\/cm3(forudsagt)
\nRTECS EE1534000
\nopbevaringstemp. \u221220\u00b0C
\nform pulver
\nVandopl\u00f8selighed Opl\u00f8seligt i vand ved 1mg\/ml
\nCAS DataBase Reference 124584-08-3<\/p>\n

Funktion og anvendelse af Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3<\/strong>
\nBehandling af kongestiv hjerteinsufficiens (renin-angiotensin-systemantagonist).<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnavn: Nesiritide \/ BNP-32 (HUMAN)
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nProduktkategorier:
\n &>Mol Fil: 124584-08-3.mol<\/p>\n","protected":false},"featured_media":2287,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[493],"product_tag":[1130],"class_list":{"0":"post-8570","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptid-for-det-kardiovaskulaere-system","7":"product_tag-nesiritide-bnp-32-human-cas-124584-08-3-brain-natriuretic-peptide-for-heart-failure-da","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product\/8570","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/comments?post=8570"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/media\/2287"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/media?parent=8570"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_brand?post=8570"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_cat?post=8570"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/da\/wp-json\/wp\/v2\/product_tag?post=8570"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}