{"id":8572,"date":"2021-12-17T01:47:30","date_gmt":"2021-12-17T06:47:30","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/nesiritide-bnp-32-mensch-cas-124584-08-3-gehirn-natriuretisches-peptid-fuer-herzinsuffizienz\/"},"modified":"2021-12-17T01:47:30","modified_gmt":"2021-12-17T06:47:30","slug":"nesiritide-bnp-32-mensch-cas-124584-08-3-gehirn-natriuretisches-peptid-fuer-herzinsuffizienz","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/de\/product\/nesiritide-bnp-32-mensch-cas-124584-08-3-gehirn-natriuretisches-peptid-fuer-herzinsuffizienz\/","title":{"rendered":"Nesiritide\/BNP-32 (MENSCH) CAS 124584-08-3 Gehirn-natriuretisches Peptid f\u00fcr Herzinsuffizienz"},"content":{"rendered":"

Nesiritide\/BNP-32 (MENSCH) CAS 124584-08-3 Gehirn-natriuretisches Peptid f\u00fcr Herzinsuffizienz<\/strong><\/h2>\n

Produktname: Nesiritide \/ BNP-32 (HUMAN)
\nSynonyme: Nesiritide,Brain Natriuretic Peptide-32 human,BNP-32, >98%;BNP-32 (human) Hydrochlorid;Nesiritid [USAN:INN] ;SPKMVQGSGCFGRKMDRISSSGLGCKVLRRH (DISULFIDBR\u00dcCKE: 10-26);SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER -SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS;H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY -ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH;H-SER-PRO-LYS -MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL -LEU-ARG-ARG-HIS-OH (DISULFIDE BRIDGE: 10-26);BRAIN NATRIURETIC PEPTID (1-32), HUMAN
\nCAS: 124584-08-3
\nMF: C143H244N500O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nProduktkategorien:
\nMol Datei: 124584-08-3.mol<\/p>\n

Nesiritid wurde in den USA als neue intraven\u00f6se Behandlung f\u00fcr Patienten mit akut dekompensierte kongestive Herzinsuffizienz mit Atemnot in Ruhe oder mit minimaler Aktivit\u00e4t it\u00e4t. Nesiritid ist die erste humane rekombinante Form des potenten vasodilatatorischen natriuretischen Peptids vom B-Typ (auch bekannt als natriuretisches Peptid des Gehirns), ein nat\u00fcrlich vorkommendes Peptid mit 32 Aminos\u00e4uren und einer Disulfid-gebundenen 17-Aminos\u00e4ure-Ringstruktur. Nesiritid bindet an den natriuretischen Peptidrezeptor vom Atyp auf der Oberfl\u00e4che von Endothel- und glatten Muskelzellen und stimuliert die Produktion des zweiten Botenstoffs cGMP, der die Relaxation der \u00fcberwiegend vaskul\u00e4ren glatten Muskelzellen vermittelt. Es erleichtert auch die Ausscheidung von Natrium und Wasser durch die Niere und verringert die Sekretion bestimmter Hormone wie Adrenalin, Angiotensin II, Aldosteron und Endothelin, die langfristige sch\u00e4dliche Wirkungen wie Blutgef\u00e4\u00dfverengung und Blutdruckerh\u00f6hung hervorrufen. In klinischen Studien mit Patienten mit Herzinsuffizienz reduzierte Nesidtid dosisabh\u00e4ngig den pulmonalen Kapillardruck, den rechten Vorhofdruck und den systemischen Gef\u00e4\u00dfwiderstand und erh\u00f6hte den Herzindex, ohne die Herzfrequenz zu beeinflussen. Die wichtigste beobachtete Nebenwirkung war eine dosisabh\u00e4ngige Hypotonie. In einer Phase-III-Vergleichsstudie wurde festgestellt, dass Nesiritid der iv \u00fcberlegen ist. Nitroglycerin in seiner h\u00e4modynamischen Wirkung sowie einfacher zu verabreichen und besser vertr\u00e4glich. Nesiritid wird durch proteolytische Spaltung durch das Enzym neutrale Endopeptidase NEP24.11 und durch Bindung an den natriuretischen Peptidrezeptor vom C-Typ gefolgt von Endocytose und intrazellul\u00e4rer lysosomaler Hydrolyse beseitigt. Da es eine kurze Halbwertszeit (18 min) hat, wird Nesiritid als 21 \u03bcg\/kg Bolusinfusion gefolgt von einer kontinuierlichen Erhaltungsinfusion mit 0,011 \u03bcg\/kg\/min in der Regel \u00fcber 24-48 Stunden verabreicht.<\/p>\n

Nesiritid \/ BNP-32 (MENSCH) CAS 124584-08-3 Chemische Eigenschaften<\/strong>
\nBNP-32 (MENSCH) Chemische Eigenschaften
\nDichte 1,52\u00b10,1 g\/cm3 (vorhergesagt)
\nRTECS EE1534000
\nLagertemp. \u221220\u00b0C
\nFormpulver
\nWasserl\u00f6slichkeit Wasserl\u00f6slich bei 1mg\/ml
\nCAS-Datenbank-Referenz 124584-08-3<\/p>\n

Funktion und Anwendung von Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3<\/strong>
\nBehandlung von kongestiver Herzinsuffizienz (Renin-Angiotensin-System-Antagonist).<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktname: Nesiritide \/ BNP-32 (HUMAN)
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nProduktkategorien: < &>Mol-Datei: 124584-08-3.mol<\/p>\n","protected":false},"featured_media":2291,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[496],"product_tag":[1132],"class_list":{"0":"post-8572","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptid-fuer-das-herz-kreislauf-system","7":"product_tag-nesiritide-bnp-32-human-cas-124584-08-3-brain-natriuretic-peptide-for-heart-failure-de","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/product\/8572","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/comments?post=8572"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/media\/2291"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/media?parent=8572"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/product_brand?post=8572"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/product_cat?post=8572"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/product_tag?post=8572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}