{"id":8774,"date":"2021-12-17T03:04:37","date_gmt":"2021-12-17T08:04:37","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/hochwertiges-goserelinacetat-cas-145781-92-6-zur-behandlung-von-brustkrebs\/"},"modified":"2021-12-17T03:04:37","modified_gmt":"2021-12-17T08:04:37","slug":"hochwertiges-goserelinacetat-cas-145781-92-6-zur-behandlung-von-brustkrebs","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/de\/product\/hochwertiges-goserelinacetat-cas-145781-92-6-zur-behandlung-von-brustkrebs\/","title":{"rendered":"Hochwertiges Goserelinacetat CAS 145781-92-6 zur Behandlung von Brustkrebs"},"content":{"rendered":"

Hochwertiges Goserelinacetat CAS 145781-92-6 zur Behandlung von Brustkrebs<\/strong><\/h2>\n

Produktname: Goserelinacetat
\nSynonyme: PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2;[(T-BU)DSER6, (AZA .) )GLY10]-LH-RH;[(T-BU)DSER6, (AZA)GLY10]-LUTEINISIERENDES HORMON FREISETZENDES HORMON;ICI-118630 Acetat;GOSERELIN HCL[PYR-HIS-TRP-SER-TYR-D-SER( T-BU)-LEU-ARG-PRO-AZAGLY-NH2];1-9-Luteinisierender Hormon-Releasing-Faktor (Schwein), 6-(o-(1,1-Dimethylethyl)-D-Serin)-, 2- (Aminocarbonyl)hydrazid, Acetat (Salz);Fertilan;GLP-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZA-GLY-NH2
\nCAS: 145781-92-6
\nMF: C59H84N18O14
\nMW: 1269.41
\nEINECS: 652-995-1
\nProduktkategorien: Peptide;Pepetide;Aminos\u00e4urederivate;Zwischenprodukte und Feinchemikalien;Peptide;Pharmazeutika
\nMol-Datei: 145781-92-6.mol<\/p>\n

Goserelinacetat ist wie Leuprolidacetat ein synthetisches Superagonist-Nonapeptid-Analogon von GnRH, das eine gr\u00f6\u00dfere Wirksamkeit als das nat\u00fcrliche Hormon besitzt. Beachten Sie, dass es D-Ser(But) und NH-NHCONH2 anstelle von Gly6 bzw. Gly10-NH2 enth\u00e4lt. Das hei\u00dft, die C-terminale Modifikation hat einfach ein NH, das das CH2 von Gly ersetzt, und wie die C-terminale Ver\u00e4nderung in Leuprolidacetat hemmt dies den enzymatischen Abbau des Peptids durch die Postprolin-Carboxyamid-Peptidase.
\nGoserelinacetat ist erh\u00e4ltlich in die Form eines kleinen, festen Pellets, das als SC-Implantat zur palliativen Behandlung von fortgeschrittenem, metastasiertem Brustkrebs bei pr\u00e4- und perimenopausalen Frauen oder \u00e4hnlich als Palliativum bei fortgeschrittenem Prostatakrebs verabreicht wird. Der Grund f\u00fcr die Verwendung dieses Arzneimittels ist, wie oben beschrieben, seine F\u00e4higkeit als Superagonist, den \u00d6stradiol- oder Testosteronspiegel auf fast kastrierte Spiegel zu bringen, wodurch das Fortschreiten des Brust- bzw. Prostatakarzinoms verlangsamt wird. Dar\u00fcber hinaus ist Goserelinacetat zur Behandlung von Endometriose f\u00fcr bis zu 6 Monate zugelassen.<\/p>\n

Goserelinacetat CAS 145781-92-6 Chemische Eigenschaften<\/strong>
\nSchmelzpunkt >190\u00b0C (Zers.)
\nLagerung temp. -20\u00b0C
\nL\u00f6slichkeit H2O: 20 mg\/mL, klar, farblos
\nwei\u00dfes Pulver
\nInChIKey IKDXDQDKCZPQSZ-JHYYTBFNSA-N
\nCAS DataBase Reference 145781-92-6<\/p>\n

Funktion und Anwendung Goserelinacetat CAS 145781-92-6<\/strong>
\n1. Antikrebs
\n2. injizierbarer Gonadotropin-Releasing-Hormon-Superagonist (GnRH-Agonist) oder antiproliferative Aktivit\u00e4t des luteinisierenden Hormons bei Brust-, Prostata- und Endometriumkrebs
\n3. Synthetisches Peptid-Agonisten-Analogon von LH-RH. Antineoplastisch (hormonell).<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktname: Goserelinacetat
\nCAS: 145781-92-6
\nMF: C59H84N18O14
\nMW: 1269.41
\nEINECS: 652-995-1
\nMol Datei: 145781-92-6.mol<\/p>\n","protected":false},"featured_media":2207,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[396],"product_tag":[960],"class_list":{"0":"post-8774","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-tumor-peptid-de","7":"product_tag-goserelin-acetate-cas-145781-92-6-used-for-treat-breast-cancer-de","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/product\/8774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/comments?post=8774"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/media\/2207"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/media?parent=8774"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/product_brand?post=8774"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/product_cat?post=8774"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/de\/wp-json\/wp\/v2\/product_tag?post=8774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}