{"id":7261,"date":"2021-12-16T07:20:04","date_gmt":"2021-12-16T12:20:04","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/enfuvirtide-acetato-cas-159519-65-0-de-enfuvirtide-para-el-vih-anti\/"},"modified":"2021-12-16T07:20:04","modified_gmt":"2021-12-16T12:20:04","slug":"enfuvirtide-acetato-cas-159519-65-0-de-enfuvirtide-para-el-vih-anti","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/es\/product\/enfuvirtide-acetato-cas-159519-65-0-de-enfuvirtide-para-el-vih-anti\/","title":{"rendered":"Enfuvirtide \/ Acetato CAS 159519-65-0 de Enfuvirtide para el VIH anti"},"content":{"rendered":"

Enfuvirtide \/ Acetato CAS 159519-65-0 de Enfuvirtide para el VIH anti<\/strong><\/h2>\n

Nombre del producto: Enfuvirtide
\n Secuencia: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys < &> – Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\n Sin\u00f3nimos: Enfuvirtide; T-2; Acetato de enfuvirtida (T-20); ENFUVIRTIDE (T-20) 98 +%; Enfurvitida (T-20); Pentafusida; Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH {2}; Enfuvirtide; Aids059486
\n CAS: 159519-65-0
\n MF: C204H301N51O64
\n MW: 4491,92
\n EINECS: 641-385-0
\n Categor\u00edas de productos : prote\u00ednas; P\u00e9ptido
\n Mol Archivo: 159519-65-0.mol <\/p>\n

Es un p\u00e9ptido sint\u00e9tico inhibidor de la fusi\u00f3n del VIH, que puede unirse a la glicoprote\u00edna de la envoltura viral y prevenir los cambios conformacionales necesarios para el virus. para fusionarse con la membrana celular, inhibiendo as\u00ed la replicaci\u00f3n del VIH-1. El p\u00e9ptido Enfevir se deriva de una secuencia de amino\u00e1cidos de origen natural en el dominio HR2 de gp41. Al simular la actividad del dominio HR2 y unirse competitivamente al dominio HR1 de gp41, el p\u00e9ptido Enfevir evita la interacci\u00f3n entre HR1 y HR2 y los cambios en la configuraci\u00f3n de Gp41, evitando as\u00ed la fusi\u00f3n del virus con las c\u00e9lulas hu\u00e9sped. <\/p>\n

Enfuvirtide es el primero de una nueva clase de terapias contra el VIH que interfiere con la entrada del VIH-1 al inhibir la fusi\u00f3n de las membranas viral y celular. Se une a la primera repetici\u00f3n de heptada (HR1) en la subunidad ghe gp41 de la glicoprote\u00edna de la envoltura viral y previene los cambios conformacionales necesarios para la fusi\u00f3n con las membranas celulares, lo que representa un nuevo mecanismo. Es un potente inhibidor de esta uni\u00f3n con una CI50 en los aislados primarios y de laboratorio (clados A \u2013 G del VIH-1) que oscilan entre 4 y 280 nM (18\u20131260 ng \/ ml), pero pr\u00e1cticamente no tiene actividad contra el VIH-2. Debido a su mecanismo \u00fanico, no muestra resistencia cruzada a NRTI, NNRTI e IP. Se prepara mediante s\u00edntesis qu\u00edmica, utilizando una combinaci\u00f3n de pasos en soluci\u00f3n y en fase s\u00f3lida. Los pasos de fase s\u00f3lida utilizan protecci\u00f3n fmoc y la resina de cloruro de 2-clorotritilo sensible a los \u00e1cidos para producir p\u00e9ptidos de longitudes que var\u00edan de nueve a diecis\u00e9is amino\u00e1cidos. <\/p>\n

Enfuvirtide \/ Enfuvirtide Acetate CAS 159519-65-0 Propiedades qu\u00edmicas<\/strong>
\n temp. De almacenamiento -20 \u00b0 C
\n forma polvo
\n color blanco a blanquecino <\/p>\n

Usos de Enfuvirtide \/ Acetato de Enfuvirtide CAS 159519-65-0<\/strong>
\n Se usa en combinaci\u00f3n con medicamentos de transcriptasa inversa para humanos infecci\u00f3n por el virus de la inmunodeficiencia (VIH).<\/p>\n","protected":false},"excerpt":{"rendered":"

Nombre del producto: Enfuvirtide
\n CAS: 159519-65-0
\n MF: C204H301N51O64
\n MW: 4491.92
\n EINECS: 641-385-0
\n Mol File: 159519-65-0.mol<\/p>\n","protected":false},"featured_media":2132,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[523],"product_tag":[2499],"class_list":{"0":"post-7261","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-otros-peptidos","7":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-es","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product\/7261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/comments?post=7261"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/media\/2132"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/media?parent=7261"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product_brand?post=7261"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product_cat?post=7261"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product_tag?post=7261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}