{"id":8432,"date":"2021-12-16T13:29:10","date_gmt":"2021-12-16T18:29:10","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/venta-caliente-de-peptidos-farmaceuticos-pasireotide-cas-396091-73-9\/"},"modified":"2021-12-16T13:29:10","modified_gmt":"2021-12-16T18:29:10","slug":"venta-caliente-de-peptidos-farmaceuticos-pasireotide-cas-396091-73-9","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/es\/product\/venta-caliente-de-peptidos-farmaceuticos-pasireotide-cas-396091-73-9\/","title":{"rendered":"Venta caliente de p\u00e9ptidos farmac\u00e9uticos Pasireotide CAS 396091-73-9"},"content":{"rendered":"

Venta caliente de p\u00e9ptidos farmac\u00e9uticos Pasireotide CAS 396091-73-9<\/strong><\/h2>\n

Nombre del producto: PASIREOTIDE
\n Sin\u00f3nimos: PASIREOTIDE; Ciclo [(2S) -2-fenilglicil-D-triptofil-L-lisil-O- (fenilmetil) -L-tirosil-L-fenilalanil- (4R) – 4 – [[[(2-aminoetil) amino] carbonil] oxi] -L-prolilo]; SOM 230; SOM 320; [(3S, 6S, 9S, 12R, 15S, 18S, 20R) -9- (4- aminobutil) -3-bencil-12- (1H-indol-3-ilmetil) -2,5,8,11,14,17-hexaoxo-15-fenil-6 – [(4-fenilmetoxifenil) metil] -1, 4,7,10,13,16-hexazabiciclo [16.3.0] henicosan-20-il] N- (2-aminoetil) carbamato; SOM 230; SOM 320; CICLO ((4R) -4- (2-AMINOETILLCARBAMOILOXIA) -L-PROLYL-L-PHENYLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-PHENYLALANYL -)
\n CAS: 396091-73-9
\n MF: C58H66N10O9 <& > MW: 1047.23
\n EINECS:
\n Categor\u00edas de productos:
\n Mol Archivo: 396091-73-9.mol <\/p>\n

En abril de 2012, la Comisi\u00f3n Europea aprob\u00f3 la pasireotida para el tratamiento de la enfermedad de Cushing ( CD) en pacientes adultos que no han respondido a la intervenci\u00f3n quir\u00fargica o para los que la cirug\u00eda no es una opci\u00f3n. La pasireotida fue aprobada para la misma indicaci\u00f3n por la FDA de EE. UU. En diciembre de 2012. (conocido como SOM230) es un ciclohexap\u00e9ptido que act\u00faa como un an\u00e1logo de la somatostatina para inhibir la liberaci\u00f3n de ACTH. Las somatostatinas son p\u00e9ptidos c\u00edclicos de 14 y 28 amino\u00e1cidos que desempe\u00f1an un papel importante en la regulaci\u00f3n de la liberaci\u00f3n endocrina y exocrina en muchos tejidos a trav\u00e9s de un mecanismo inhibidor. Hay cinco subtipos conocidos de receptores de somatostatina (SSTR). Las somatostatinas naturales se unen con alta afinidad a los cinco subtipos, sin embargo, su uso terap\u00e9utico est\u00e1 limitado por la r\u00e1pida degradaci\u00f3n en plasma. La pasireotida surgi\u00f3 de los esfuerzos para identificar un somatostatinmim\u00e9tico con efectos inhibidores de larga duraci\u00f3n. Comenzando con un p\u00e9ptido de somatostatina de 14 amino\u00e1cidos, una exploraci\u00f3n sistem\u00e1tica de alanina revel\u00f3 residuos que eran esenciales para la uni\u00f3n del subtipo de receptor, incluidas regiones clave de giro b y residuos adyacentes. La colocaci\u00f3n de los elementos estructurales clave como amino\u00e1cidos no naturales en una cadena principal de ciclohexap\u00e9ptido dio pasireotida. <\/p>\n

PASIREOTIDE CAS 396091-73-9<\/strong>
\n Punto de ebullici\u00f3n 1351,4 \u00b1 65,0 \u00b0 C (predicho)
\n densidad 1,36 \u00b1 0,1 g \/ cm3 (Previsto)
\n pka 11,86 \u00b1 0,46 (Previsto)
\n Referencia de la base de datos CAS 396091-73-9 <\/p>\n

Funci\u00f3n y aplicaci\u00f3n de PASIREOTIDE CAS 396091-73-9<\/strong>
\n Como inhibidor del crecimiento Como an\u00e1logo que se une a m\u00faltiples receptores, se ha demostrado que la pasireotida es m\u00e1s eficaz que los an\u00e1logos inhibidores del crecimiento como la octreotida y la lanreotida en el tratamiento de la acromegalia, los tumores carcinoides y la enfermedad de Cushing, tanto en ensayos precl\u00ednicos como en ensayos celulares y estudios en animales, y en ensayos cl\u00ednicos. Los resultados del ensayo de fase II y un ensayo de fase III sobre pasireotida han confirmado que pasireotide es un nuevo tratamiento para la acromegalia persistente y los tumores carcinoides metast\u00e1sicos nuevos o persistentes, y puede ser la primera opci\u00f3n de tratamiento farmacol\u00f3gico para la enfermedad de Cushing.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nombre del producto: PASIREOTIDE
\n MF: C58H66N10O9
\n MW: 1047.23
\n EINECS:
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