{"id":8586,"date":"2021-12-17T01:48:29","date_gmt":"2021-12-17T06:48:29","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/nesiritide-bnp-32-human-cas-124584-08-3-peptido-natriuretico-cerebral-para-insuficiencia-cardiaca\/"},"modified":"2021-12-17T01:48:29","modified_gmt":"2021-12-17T06:48:29","slug":"nesiritide-bnp-32-human-cas-124584-08-3-peptido-natriuretico-cerebral-para-insuficiencia-cardiaca","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/es\/product\/nesiritide-bnp-32-human-cas-124584-08-3-peptido-natriuretico-cerebral-para-insuficiencia-cardiaca\/","title":{"rendered":"Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 P\u00e9ptido natriur\u00e9tico cerebral para insuficiencia card\u00edaca"},"content":{"rendered":"

Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 P\u00e9ptido natriur\u00e9tico cerebral para insuficiencia card\u00edaca<\/strong><\/h2>\n

Nombre del producto: Nesiritide \/ BNP-32 (HUMAN)
\n Sin\u00f3nimos: Nesiritide, Brain Natriuretic Peptide-32 human, BNP-32,> 98%; BNP-32 (human) hydrochloride; Nesiritide [USAN: INN] ; SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (PUENTE DE DISULFURO: 10-26); SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER -SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS; H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY -ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH; H-SER-PRO-LYS -MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL -LEU-ARG-ARG-HIS-OH (PUENTE DE DISULFURO: 10-26); P\u00c9PTIDO CEREBRAL NATRIUR\u00c9TICO (1-32), HUMANO
\n CAS: 124584-08-3
\n MF: C143H244N50O42S4
\n MW: 3464.04
\n EINECS: 1312995-182-4
\n Categor\u00edas de producto:
\n Archivo Mol: 124584-08-3.mol <\/p>\n

Nesiritide se introdujo en los EE. UU. Como un nuevo tratamiento intravenoso para pacientes con Insuficiencia card\u00edaca congestiva agudamente descompensada que tienen disnea en reposo o con actividad m\u00ednima. ity. Nesiritide es la primera forma humana recombinante del potente p\u00e9ptido natriur\u00e9tico vasodilatador de tipo B (tambi\u00e9n conocido como p\u00e9ptido natriur\u00e9tico cerebral), un p\u00e9ptido natural de 32 amino\u00e1cidos con una estructura de anillo de 17 amino\u00e1cidos unidos por enlaces disulfuro. La nesiritida se une al receptor del p\u00e9ptido natriur\u00e9tico de tipo A en la superficie de las c\u00e9lulas endoteliales y del m\u00fasculo liso estimulando la producci\u00f3n del segundo mensajero cGMP que media predominantemente la relajaci\u00f3n de las c\u00e9lulas del m\u00fasculo liso vascular. Tambi\u00e9n facilita la eliminaci\u00f3n de sodio y agua por el ri\u00f1\u00f3n y disminuye la secreci\u00f3n de ciertas hormonas, como adrenalina, angiotensina II, aldosterona y endotelina, que provocan efectos perjudiciales a largo plazo que incluyen la constricci\u00f3n de los vasos sangu\u00edneos y la elevaci\u00f3n de la presi\u00f3n arterial. En ensayos cl\u00ednicos con pacientes con insuficiencia card\u00edaca, la nesidtida redujo de manera dependiente de la dosis la presi\u00f3n de enclavamiento capilar pulmonar, la presi\u00f3n de la aur\u00edcula derecha y la resistencia vascular sist\u00e9mica y aument\u00f3 el \u00edndice card\u00edaco sin afectar la frecuencia card\u00edaca. El principal efecto adverso observado fue la hipotensi\u00f3n dosis-dependiente. En un ensayo comparativo de fase III, se encontr\u00f3 que la nesiritida era superior a la iv. nitroglicerina en sus efectos hemodin\u00e1micos adem\u00e1s de m\u00e1s f\u00e1cil de administrar y mejor tolerada. La nesiritida se aclara por escisi\u00f3n proteol\u00edtica por la enzima endopeptidasa neutra NEP24.11 y por uni\u00f3n al receptor del p\u00e9ptido natriur\u00e9tico de tipo C seguido de endocitosis e hidr\u00f3lisis lisosomal intracelular. Dado que tiene una vida media corta (18 min), la nesiritida se administra como una infusi\u00f3n en bolo de 21 \u03bcg \/ kg seguida de una infusi\u00f3n de mantenimiento continua a 0.011 \u03bcg \/ kg \/ min, generalmente durante 24-48 horas. <\/p>\n

Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Propiedades qu\u00edmicas<\/strong>
\n BNP-32 (HUMAN) Propiedades qu\u00edmicas
\n densidad 1,52 \u00b1 0,1 g \/ cm3 (Previsto)
\n RTECS EE1534000
\n temp. De almacenamiento \u221220 \u00b0 C
\n forma polvo
\n Solubilidad en agua Soluble en agua a 1 mg \/ ml
\n Referencia de la base de datos CAS 124584-08-3 <\/p>\n

Funci\u00f3n y aplicaci\u00f3n de Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3<\/strong>
\n Tratamiento de insuficiencia card\u00edaca congestiva (antagonista del sistema renina-angiotensina).<\/p>\n","protected":false},"excerpt":{"rendered":"

Nombre del producto: Nesiritide \/ BNP-32 (HUMAN)
\n CAS: 124584-08-3
\n MF: C143H244N50O42S4
\n MW: 3464.04
\n EINECS: 1312995-182-4
\n Categor\u00edas de productos: < &> Archivo Mol: 124584-08-3.mol<\/p>\n","protected":false},"featured_media":2300,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[504],"product_tag":[1146],"class_list":{"0":"post-8586","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptido-del-sistema-cardiovascular","7":"product_tag-nesiritide-bnp-32-human-cas-124584-08-3-brain-natriuretic-peptide-for-heart-failure-es","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product\/8586","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/comments?post=8586"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/media\/2300"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/media?parent=8586"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product_brand?post=8586"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product_cat?post=8586"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product_tag?post=8586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}