{"id":8802,"date":"2021-12-17T03:07:19","date_gmt":"2021-12-17T08:07:19","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/acetato-de-goserelina-de-alta-calidad-cas-145781-92-6-usado-para-tratar-el-cancer-de-mama\/"},"modified":"2021-12-17T03:07:19","modified_gmt":"2021-12-17T08:07:19","slug":"acetato-de-goserelina-de-alta-calidad-cas-145781-92-6-usado-para-tratar-el-cancer-de-mama","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/es\/product\/acetato-de-goserelina-de-alta-calidad-cas-145781-92-6-usado-para-tratar-el-cancer-de-mama\/","title":{"rendered":"Acetato de goserelina de alta calidad CAS 145781-92-6 usado para tratar el c\u00e1ncer de mama"},"content":{"rendered":"

Acetato de goserelina de alta calidad CAS 145781-92-6 usado para tratar el c\u00e1ncer de mama<\/strong><\/h2>\n

Nombre del producto: Acetato de goserelina
\n Sin\u00f3nimos: PYR-HIS-TRP-SER-TYR-D-SER (TBU) -LEU-ARG-PRO-AZAGLY-NH2; [(T-BU) DSER6, (AZA ) GLY10] -LH-RH; [(T-BU) DSER6, (AZA) GLY10] -HORMONA LIBERADORA DE HORMONA LUTEINIZADORA; acetato de ICI-118630; GOSERELIN HCL [PYR-HIS-TRP-SER-TYR-D-SER ( T-BU) -LEU-ARG-PRO-AZAGLY-NH2]; 1-9-Factor liberador de hormona luteinizante (porcinos), 6- (o- (1,1-dimetiletil) -D-serina) -, 2- (aminocarbonil) hidrazida, acetato (sal); Fertilan; GLP-HIS-TRP-SER-TYR-D-SER (TBU) -LEU-ARG-PRO-AZA-GLY-NH2
\n CAS: 145781-92-6
\n MF: C59H84N18O14
\n MW: 1269.41
\n EINECS: 652-995-1
\n Categor\u00edas de productos: P\u00e9ptido; P\u00e9ptidos; Derivados de amino\u00e1cidos; Productos qu\u00edmicos intermedios y finos; P\u00e9ptidos; Productos farmac\u00e9uticos
\n Archivo Mol: 145781-92-6.mol ^ {&>
\n El acetato de goserelina, como el acetato de leuprolida, es un an\u00e1logo nonapept\u00eddico superagonista sint\u00e9tico de GnRH que posee mayor potencia que la hormona natural. Tenga en cuenta que contiene D-Ser (But) y NH-NHCONH2 en lugar de Gly6 y Gly10-NH2, respectivamente. Es decir, la modificaci\u00f3n C terminal simplemente tiene un NH que sustituye al CH2 de Gly, y al igual que el cambio C-terminal en el acetato de leuprolida, esto inhibe la degradaci\u00f3n enzim\u00e1tica del p\u00e9ptido por la carboxiamida peptidasa postprolina.
\n El acetato de goserelina est\u00e1 disponible en en forma de un peque\u00f1o gr\u00e1nulo s\u00f3lido que se administra como un implante subcut\u00e1neo para el tratamiento paliativo del c\u00e1ncer de mama metast\u00e1sico avanzado en mujeres pre y perimenop\u00e1usicas o, de manera similar, como paliativo en el c\u00e1ncer de pr\u00f3stata avanzado. La raz\u00f3n fundamental para el uso de este f\u00e1rmaco es, como se describi\u00f3 anteriormente, su capacidad como superagonista para llevar los niveles de estradiol o testosterona a niveles cercanos a la castraci\u00f3n, lo que ralentiza la progresi\u00f3n del carcinoma de mama o de pr\u00f3stata, respectivamente. Adem\u00e1s, el acetato de goserelina est\u00e1 aprobado para su uso en el tratamiento de la endometriosis hasta por 6 meses. <\/p>\n

Acetato de goserelina CAS 145781-92-6 Propiedades qu\u00edmicas<\/strong>
\n Punto de fusi\u00f3n> 190 \u00b0 C (dec.)
\n Almacenamiento temperatura -20 \u00b0 C
\n solubilidad H2O: 20 mg \/ mL, transparente, incoloro
\n en forma de polvo blanco
\n InChIKey IKDXDQDKCZPQSZ-JHYYTBFNSA-N
\n CAS DataBase Reference 145781-92-6 <\/p>\n

Funci\u00f3n y aplicaci\u00f3n Acetato de goserelina CAS 145781-92-6<\/strong>
\n 1. Anticancer\u00edgeno
\n 2. superagonista de hormona liberadora de gonadotropina inyectable (agonista de GnRH) o actividad antiproliferativa de hormona luteinizante en c\u00e1nceres de mama, pr\u00f3stata y endometrio
\n 3. An\u00e1logo agonista de p\u00e9ptido sint\u00e9tico de LH-RH. Antineopl\u00e1sico (hormonal).<\/p>\n","protected":false},"excerpt":{"rendered":"

Nombre del producto: Acetato de goserelina
\n CAS: 145781-92-6
\n MF: C59H84N18O14
\n MW: 1269.41
\n EINECS: 652-995-1
\n Mol Archivo: 145781-92-6.mol<\/p>\n","protected":false},"featured_media":2216,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[385],"product_tag":[973],"class_list":{"0":"post-8802","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptido-antitumoral","7":"product_tag-goserelin-acetate-cas-145781-92-6-used-for-treat-breast-cancer-es","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product\/8802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/comments?post=8802"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/media\/2216"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/media?parent=8802"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product_brand?post=8802"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product_cat?post=8802"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/es\/wp-json\/wp\/v2\/product_tag?post=8802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}