{"id":7263,"date":"2021-12-16T07:20:05","date_gmt":"2021-12-16T12:20:05","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/enfuvirtidi-enfuvirtide-acetate-cas-159519-65-0-hivn-torjuntaan\/"},"modified":"2021-12-16T07:20:05","modified_gmt":"2021-12-16T12:20:05","slug":"enfuvirtidi-enfuvirtide-acetate-cas-159519-65-0-hivn-torjuntaan","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fi\/product\/enfuvirtidi-enfuvirtide-acetate-cas-159519-65-0-hivn-torjuntaan\/","title":{"rendered":"Enfuvirtidi \/ Enfuvirtide Acetate CAS 159519-65-0 HIV:n torjuntaan"},"content":{"rendered":"

Enfuvirtidi \/ Enfuvirtide Acetate CAS 159519-65-0 HIV:n torjuntaan<\/strong><\/h2>\n

Tuotteen nimi: Enfuvirtide
\nSekvenssi: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys< &>-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\nSynonyymit: Enfuvirtidi; T-2; Enfuvirtidiasetaatti (T-20); ENFUVIRTIDE (T-20) 98+ %; Enfurvitidi (T-20); pentafusidi; Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH{2};Enfuvirtidi;Aids059486
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-385-0 Ca<gories : proteiinit;Peptidi
\nMol Tiedosto: 159519-65-0.mol<\/p>\n

Se on HIV-fuusion synteettinen peptidi-inhibiittori, joka voi sitoutua viruksen vaipan glykoproteiiniin ja est\u00e4\u00e4 virukselle v\u00e4ltt\u00e4m\u00e4tt\u00f6mi\u00e4 konformaatiomuutoksia fuusioimaan solukalvon kanssa, est\u00e4en siten HIV-1:n replikaatiota. Enfevir-peptidi on per\u00e4isin gp41:n HR2-domeenissa luonnollisesti esiintyv\u00e4st\u00e4 aminohapposekvenssist\u00e4. Simuloimalla HR2-domeenin aktiivisuutta ja sitoutumalla kilpailevasti gp41:n HR1-domeeniin, Enfevir-peptidi est\u00e4\u00e4 HR1:n ja HR2:n v\u00e4list\u00e4 vuorovaikutusta ja muutoksia Gp41:n konfiguraatiossa, mik\u00e4 est\u00e4\u00e4 viruksen fuusion is\u00e4nt\u00e4solujen kanssa.<\/p>\n

Enfuvirtidi on ensimm\u00e4inen uudesta HIV-l\u00e4\u00e4kkeiden luokasta, joka h\u00e4iritsee HIV-1:n p\u00e4\u00e4sy\u00e4 sis\u00e4\u00e4n est\u00e4m\u00e4ll\u00e4 virus- ja solukalvojen fuusiota. Se sitoutuu viruksen vaippaglykoproteiinin ghe gp41 -alayksik\u00f6n ensimm\u00e4iseen heptad-toistoon (HR1) ja est\u00e4\u00e4 konformaatiomuutoksia, joita tarvitaan fuusiossa solukalvojen kanssa, edustaen siten uutta mekanismia. Se on voimakas t\u00e4m\u00e4n sitoutumisen est\u00e4j\u00e4, ja sen IC50-arvo laboratorio- ja prim\u00e4\u00e4risolaateissa (HIV-1-kladit A\u2013G) on v\u00e4lill\u00e4 4\u2013280 nM (18\u20131260 ng\/ml), mutta sill\u00e4 ei ole k\u00e4yt\u00e4nn\u00f6ss\u00e4 lainkaan aktiivisuutta HIV-2:ta vastaan. Ainutlaatuisen mekanisminsa ansiosta se ei osoita ristiresistenssi\u00e4 NRTI:lle, NNRTI:lle ja PI:ille. Se valmistetaan kemiallisella synteesill\u00e4 k\u00e4ytt\u00e4m\u00e4ll\u00e4 liuos- ja kiinte\u00e4faasivaiheiden yhdistelm\u00e4\u00e4. Kiinte\u00e4n faasin vaiheissa k\u00e4ytet\u00e4\u00e4n fmoc-suojausta ja happoherkk\u00e4\u00e4 2-klooritrityylikloridihartsia tuottamaan peptidej\u00e4, joiden pituus vaihtelee yhdeks\u00e4st\u00e4 kuuteentoista aminohappoon. <\/p>\n

Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 Kemialliset ominaisuudet<\/strong>
\nvarastointil\u00e4mp\u00f6tila. -20\u00b0C
\njauheen muoto
\nv\u00e4ri valkoinen tai luonnonvalkoinen<\/p>\n

Enfuvirtidi\/enfuvirtidiasetaatin CAS 159519-65-0 k\u00e4ytt\u00f6tarkoitukset<\/strong>
\nK\u00e4ytet\u00e4\u00e4n yhdess\u00e4 ihmisille tarkoitettujen k\u00e4\u00e4nteiskopioijal\u00e4\u00e4kkeiden kanssa immuunikatovirus (HIV) -infektio.<\/p>\n","protected":false},"excerpt":{"rendered":"

Tuotenimi: Enfuvirtidi
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-385-0
\nMol Tiedosto: 159519-65-0.moll<\/p>\n","protected":false},"featured_media":2121,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[532],"product_tag":[2501],"class_list":{"0":"post-7263","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-muut-peptidit","7":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-fi","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product\/7263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/comments?post=7263"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/media\/2121"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/media?parent=7263"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_brand?post=7263"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_cat?post=7263"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_tag?post=7263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}