{"id":8100,"date":"2021-12-16T12:18:39","date_gmt":"2021-12-16T17:18:39","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/zikonotidiasetaatti-cas-107452-89-1-hoito-postherpeettiseen-neuralgiaan-ja-syopakipuun\/"},"modified":"2021-12-16T12:18:39","modified_gmt":"2021-12-16T17:18:39","slug":"zikonotidiasetaatti-cas-107452-89-1-hoito-postherpeettiseen-neuralgiaan-ja-syopakipuun","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fi\/product\/zikonotidiasetaatti-cas-107452-89-1-hoito-postherpeettiseen-neuralgiaan-ja-syopakipuun\/","title":{"rendered":"Zikonotidiasetaatti CAS 107452-89-1 Hoito postherpeettiseen neuralgiaan ja sy\u00f6p\u00e4kipuun"},"content":{"rendered":"

Zikonotidiasetaatti CAS 107452-89-1 Hoito postherpeettiseen neuralgiaan ja sy\u00f6p\u00e4kipuun<\/strong><\/h2>\n

Tuotteen nimi: Zikonotidiasetaatti
\nSynonyymit: OMEGA-CONOTOXIN MVIIA;OMEGA-CGTX MVII A;ZICONOTIDE ACETATE;snx111;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG -LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS -SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDISILTA: 1-16, 8-20 JA 15 -25);CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY- LYS-CYS-NH2;CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFIDISILTA: 1-16,8-20 JA 15-25)
\nCAS: 107452-89-1
\nMF: C102H172N36O32S.1:3&2>32S. >EINECS:
\nTuoteluokat: Peptidi
\nMol File: 107452-89-1.mol<\/p>\n

Ziconotide (Prialt) on 25 aminohapon, kolme disulfidisidoksella sidottu peptiditoksiiniyhdiste, joka on per\u00e4isin etel\u00e4st\u00e4 Tyynenmeren merietana Conusmagus. Se on ensimm\u00e4inen uusi neuroterapeuttinen aine – N-tyypin kalsiumkanavan salpaaja (NCCB). Se vaikuttaa valikoivasti N-tyypin s\u00e4hk\u00f6herkkiin Chemicalbook-kalsiumkanaviin dendriittisiss\u00e4 ja aksonaalisissa terminaalisissa haaroissa ja est\u00e4\u00e4 siten alkuper\u00e4isen vaurion \u00e4rsykkeen afferenteja. Se on tarkoitettu potilaille, joilla on vaikea krooninen kipu, jotka tarvitsevat intratekaalista hoitoa ja jotka eiv\u00e4t sied\u00e4 muita kipua lievitt\u00e4vi\u00e4 hoitoja tai joiden teho on heikko (esim. systeemisten kipul\u00e4\u00e4kkeiden tai intratekaalisen morfiinin k\u00e4ytt\u00f6). Intratekaalista tsikonotidia voidaan k\u00e4ytt\u00e4\u00e4 postherpeettisen neuralgian, haamuraajojen, HIV-per\u00e4isen neuropaattisen kivun, refraktaarisen sy\u00f6p\u00e4kivun ja leikkauksen j\u00e4lkeisen kivun hoitoon.<\/p>\n

Zikonotidiasetaatti CAS 107452-89-1 Kemialliset ominaisuudet<\/strong>
\ntiheys 1,60\u00b10,1 g\/cm3 (ennustettu)
\nvarastointil\u00e4mp\u00f6tila. -20\u00b0C
\nInChIKey BPKIMPVREBSLAJ-QTBYCLKRSA-N<\/p>\n

Zikonotidiasetaatin CAS 107452-89-1 k\u00e4ytt\u00f6tarkoitukset<\/strong>
\nLigandin j\u00e4nniteherkkien kalsiumkanavien sitoutumistutkimuksiin.<\/p>\n

Tsikonotidi ( SNX-111; Prialt, jota kutsutaan my\u00f6s intratekaaliseksi tsikonotidiksi (ITZ) sen antoreitin vuoksi, on ep\u00e4tyypillinen analgeettinen aine vaikean ja kroonisen kivun lievitykseen. Se on johdettu Conus magusista, kartioetanoista, ja se on synteettinen muoto \u03c9-konotoksiinipeptidist\u00e4.[1] Se on 1000 kertaa tehokkaampi kuin morfiini.<\/p>\n

T\u00e4m\u00e4 tuote sopii potilaille, joilla on vaikea krooninen kipu, jotka tarvitsevat intratekaalista hoitoa ja jotka eiv\u00e4t sied\u00e4 muita kipua lievitt\u00e4vi\u00e4 hoitoja tai joiden teho on heikko (kuten systeemisten kipul\u00e4\u00e4kkeiden tai morfiinin intratekaalinen injektio jne.).<\/p>\n

Zikonotidiasetaatin toiminta ja k\u00e4ytt\u00f6 CAS 107452-89-1<\/strong>
\n1. Analgeettinen teho Zikonotidi soveltuu kroonista kipua hoitaville potilaille, jotka eiv\u00e4t sied\u00e4 muita hoitoja tai eiv\u00e4t reagoi niihin, mukaan lukien systeeminen l\u00e4\u00e4kitys, intratekaalisen morfiinin injektion adjuvanttihoito. Tsikonotidin intratekaalisella injektiolla on kliinisesti ja tilastollisesti merkitsev\u00e4 analgeettinen teho sy\u00f6p\u00e4- tai AIDS-potilailla.<\/p>\n

2. Selk\u00e4ytimen suojaus Lyhytaikainen selk\u00e4ytimen iskemia Kun selk\u00e4ytimen hermosolut vaurioituvat, tapahtuu N-tyypin s\u00e4hk\u00f6herk\u00e4n kalsiumreitin aktivaatio. Zikonotidi voi tarjota hermosolujen suojan ja kivunlievityksen aorttaleikkauksen aikana.<\/p>\n","protected":false},"excerpt":{"rendered":"

Tuotteen nimi: Zikonotidiasetaatti
\nCAS: 107452-89-1
\nMF: C102H172N36O32S7
\nMW: 2639.13
\nMol Tiedosto: 107452-89-1.mol<\/p>\n","protected":false},"featured_media":2205,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[532],"product_tag":[1583],"class_list":{"0":"post-8100","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-muut-peptidit","7":"product_tag-ziconotide-acetate-cas-107452-89-1-treat-for-postherpetic-neuralgia-and-cancer-pain-fi","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product\/8100","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/comments?post=8100"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/media\/2205"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/media?parent=8100"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_brand?post=8100"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_cat?post=8100"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_tag?post=8100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}