{"id":8382,"date":"2021-12-16T13:26:55","date_gmt":"2021-12-16T18:26:55","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/pramlintide-acetate-cas-196078-30-5-on-diabeteslaake-jota-voidaan-kayttaa-myos-suolistosyopatutkimuksessa\/"},"modified":"2021-12-16T13:26:55","modified_gmt":"2021-12-16T18:26:55","slug":"pramlintide-acetate-cas-196078-30-5-on-diabeteslaake-jota-voidaan-kayttaa-myos-suolistosyopatutkimuksessa","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fi\/product\/pramlintide-acetate-cas-196078-30-5-on-diabeteslaake-jota-voidaan-kayttaa-myos-suolistosyopatutkimuksessa\/","title":{"rendered":"Pramlintide Acetate CAS 196078-30-5 on diabetesl\u00e4\u00e4ke, jota voidaan k\u00e4ytt\u00e4\u00e4 my\u00f6s suolistosy\u00f6p\u00e4tutkimuksessa"},"content":{"rendered":"

Pramlintide Acetate CAS 196078-30-5 on diabetesl\u00e4\u00e4ke, jota voidaan k\u00e4ytt\u00e4\u00e4 my\u00f6s suolistosy\u00f6p\u00e4tutkimuksessa<\/strong><\/h2>\n

Tuotteen nimi: Pramlintide-asetaatti
\nSynonyymit: AMYLIN (IHMIS), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE; pramlintide acetate; pramlintide asetaattihydraatti ;25-L-proliini-28-L-proliini-29-L-proliini-amyliini (ihmisen) asetaattihydraatti; AC-137-asetaattihydraatti, syMlin-asetaattihydraatti; tripo-amyliiniasetaattihydraatti; pramlintidiasetaatti P, amylintidirotti; fandachem
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027.46
\nEINECS:
\nTuoteluokat: Aminohapot ja johdannaiset;Em\u00e4kset ja niihin liittyv\u00e4t analogisyklit; & Fine Chemicals; Nucleotids;Peptide;Pharmaceuticals;Mol File: 196078-30-5.mol<\/p>\n

Pramlintide-asetaatti on injektoitava ihmisen amyliinianalogi, joka on tuotu markkinoille sek\u00e4 tyypin 1 ett\u00e4 tyypin 2 hoitoon. diabetes, yhdess\u00e4 insuliinin kanssa. Vaikka se on my\u00f6s 37 aminohapon peptidi, se eroaa alkuper\u00e4isest\u00e4 edelt\u00e4j\u00e4st\u00e4\u00e4n substituoimalla Ala-25, Ser-28 ja Ser-29 proliinilla. N\u00e4m\u00e4 modifikaatiot eiv\u00e4t ainoastaan paranna peptidin liukoisuutta, vaan ne my\u00f6s eliminoivat amyliinin kanssa havaitun aggregaation, mik\u00e4 johtaa stabiiliin synteettiseen analogiin, joka s\u00e4ilytt\u00e4\u00e4 biologisen aktiivisuuden ja joka sopii farmaseuttiseen k\u00e4ytt\u00f6\u00f6n. Tehon osoituksena Pramlintide-asetaatti est\u00e4\u00e4 radiojodatun rotan amyliinin sitoutumisen rotan nucleus accumbens -kalvoihin Ki-arvolla 23 pM. Sen vaikutusmekanismi j\u00e4ljittelee amyliini\u00e4; neurohormonina, joka erittyy yhdess\u00e4 insuliinin kanssa haiman \u03b2-soluista vastauksena aterioihin, se osallistuu glukoosin homeostaasiin. Molemmat peptidit alentavat aterian j\u00e4lkeist\u00e4 glukoositasoa est\u00e4m\u00e4ll\u00e4 glukagonia ja hillitsem\u00e4ll\u00e4 vagus-v\u00e4litteist\u00e4 mahalaukun tyhjenemisnopeutta, mik\u00e4 hidastaa hiilihydraattien imeytymist\u00e4 suolistosta. Lis\u00e4ksi amyliinilla tai pramlintide-asetaatilla on lis\u00e4etu, joka indusoi aterian j\u00e4lkeist\u00e4 kyll\u00e4isyytt\u00e4, mik\u00e4 johtaa painon laskuun potilailla, joilla on tyypin 2 diabetes. Koska Pramlintide-asetaatti hidastaa mahalaukun tyhjenemist\u00e4, se on vasta-aiheinen potilailla, joilla on gastropareesi, ja potilaille, jotka k\u00e4ytt\u00e4v\u00e4t l\u00e4\u00e4kkeit\u00e4, jotka muuttavat ruoansulatuskanavan motiliteettia (antikolinergiset aineet, kuten atropiini) tai hidastavat ravintoaineiden imeytymist\u00e4 suolistosta (kuten \u03b1-glukosidaasi-inhibiittorit). Pramlintide-asetaatti on my\u00f6s vasta-aiheinen potilailla, joilla on hypoglykeemisi\u00e4 taipumuksia; insuliinin samanaikaisen annon vuoksi vakava insuliinin aiheuttama hypoglykemia on riski. Yleisimmin raportoituja haittavaikutuksia ovat pahoinvointi, oksentelu, ruokahaluttomuus, p\u00e4\u00e4ns\u00e4rky, vatsakipu, v\u00e4symys, huimaus, ysk\u00e4 ja nielutulehdus.<\/p>\n

CAS 196078-30-5:n toiminta ja k\u00e4ytt\u00f6<\/strong> <\/p>\n

Pramlintide asetaatti on haiman amyloidipolypeptidin (amyliini, amylopektiini) synteettinen analogi ja toinen tyypin 1 diabeteksen hoitoon hyv\u00e4ksytty l\u00e4\u00e4ke insuliinin j\u00e4lkeen. Kliinisess\u00e4 k\u00e4yt\u00e4nn\u00f6ss\u00e4 pramlintidia k\u00e4ytet\u00e4\u00e4n adjuvanttil\u00e4\u00e4kkeen\u00e4 tyypin 1 ja tyypin 2 diabeteksen hoidossa p\u00e4\u00e4asiassa diabeetikoilla, jotka eiv\u00e4t ole saavuttaneet odotettuja tuloksia pelk\u00e4ll\u00e4 insuliinilla sek\u00e4 insuliinin ja sulfonyyliureoiden ja metformiinin yhdistelm\u00e4ll\u00e4. Pramlintidea voidaan k\u00e4ytt\u00e4\u00e4 yhdess\u00e4 insuliinin kanssa, mutta se ei voi korvata insuliinia.<\/p>\n","protected":false},"excerpt":{"rendered":"

Tuotteen nimi: Pramlintide asetaatti
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027.46
\nMol Tiedosto: 196078-30-5.mol<\/p>\n","protected":false},"featured_media":2205,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[340,340,340,340],"product_tag":[1295],"class_list":{"0":"post-8382","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-diabetes-peptidi","10":"product_tag-pramlintide-acetate-cas-196078-30-5-is-an-antidiabetic-agent-that-can-also-be-used-in-bowel-cancer-research-fi","11":"desktop-align-left","12":"tablet-align-left","13":"mobile-align-left","15":"first","16":"instock","17":"shipping-taxable","18":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product\/8382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/comments?post=8382"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/media\/2205"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/media?parent=8382"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_brand?post=8382"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_cat?post=8382"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_tag?post=8382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}