{"id":8415,"date":"2021-12-16T13:28:05","date_gmt":"2021-12-16T18:28:05","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/hot-sale-farmaseuttiset-peptidit-pasireotidi-cas-396091-73-9\/"},"modified":"2021-12-16T13:28:05","modified_gmt":"2021-12-16T18:28:05","slug":"hot-sale-farmaseuttiset-peptidit-pasireotidi-cas-396091-73-9","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fi\/product\/hot-sale-farmaseuttiset-peptidit-pasireotidi-cas-396091-73-9\/","title":{"rendered":"Hot Sale farmaseuttiset peptidit Pasireotidi CAS 396091-73-9"},"content":{"rendered":"

Hot Sale farmaseuttiset peptidit Pasireotidi CAS 396091-73-9<\/strong><\/h2>\n

Tuotteen nimi: PASIREOTIDE
\nSynonyymit: PASIREOTIDE;Syklo[(2S)-2-fenyyliglysyyli-D-tryptofyyli-L-lysyyli-O-(fenyylimetyyli)-L-tyrosyyli-L-fenyylialanyyli-(4R)- 4-[[[(2-aminoetyyli)amino]karbonyyli]oksi]-L-prolyyli]; SOM 230; SOM 320; [(3S,6S,9S,12R,15S,18S,20R)-9-(4- aminobutyyli)-3-bentsyyli-12-(1 H-indol-3-yylimetyyli)-2,5,8,11,14,17-heksaokso-15-fenyyli-6-[(4-fenyylimetoksifenyyli)metyyli]-1, 4,7,10,13,16-heksatsabisyklo[16.3.0]henikosan-20-yyli]-N-(2-aminoetyyli)karbamaatti; SOM 230; SOM 320; SYKLO((4R)-4-(2-aminoetyylikarbamoyloksi) -L-PROLYYLI-L-FENYLGLYSYYLI-D-TRYPTOFYYLI-L-LYSYYLI-4-O-BENTSYYLI-L-TYROSYLI-L-FENYLLANYLI-)
\nCAS: 396091-73-9
\nMF: C58H66<&N10O9 >MW: 1047.23
\nEINECS:
\nTuoteluokat:
\nMol Tiedosto: 396091-73-9.mol<\/p>\n

Euroopan komissio hyv\u00e4ksyi huhtikuussa 2012 pasireotidin Cushingin taudin hoitoon ( CD). nyt SOM230) on sykloheksapeptidi, joka toimii somatostatiinianalogina ACTH:n vapautumisen est\u00e4miseksi. Somatostatiinit ovat 14 ja 28 aminohapon syklisi\u00e4 peptidej\u00e4, joilla on t\u00e4rke\u00e4 rooli endokriinisen ja deksokriinisen aineen vapautumisen s\u00e4\u00e4telyss\u00e4 useissa kudoksissa estomekanismin kautta. Somatostatiinireseptoreista (SSTR:t) tunnetaan viisi alatyyppi\u00e4. Luonnolliset somatostatiinit sitoutuvat suurella affiniteetilla kaikkiin viiteen alatyyppiin, mutta niiden terapeuttista k\u00e4ytt\u00f6\u00e4 rajoittaa nopea hajoaminen plasmassa. Pasireotidi syntyi yrityksist\u00e4 tunnistaa somatostatiinia j\u00e4ljittelev\u00e4 aine, jolla on pitk\u00e4kestoisia est\u00e4vi\u00e4 vaikutuksia. Alkaen 14 aminohapon somatostatiinipeptidist\u00e4, systemaattinen alaniiniskannaus paljasti t\u00e4hteit\u00e4, jotka olivat v\u00e4ltt\u00e4m\u00e4tt\u00f6mi\u00e4 reseptorin alatyypin sitoutumiselle, mukaan lukien keskeiset b-k\u00e4\u00e4nn\u00f6salueet ja viereiset t\u00e4hteet. Avainrakenneosien sijoittaminen ep\u00e4luonnollisina aminohappoina sykloheksapeptidirunkoon tuotti pasireotidin.<\/p>\n

PASIREOTIDE CAS 396091-73-9<\/strong>
\nKiehumispiste 1351,4\u00b165,0 \u00b0C (ennustettu)
\ntiheys 1,36\u00b10,1 g. \/cm3(ennustettu)
\npka 11,86\u00b10,46(ennustettu)
\nCAS-tietokannan viite 396091-73-9<\/p>\n

PASIREOTIDE CAS 396091-73-9:n toiminta ja k\u00e4ytt\u00f6<\/strong>
\nKasvun est\u00e4j\u00e4n\u00e4 Useisiin reseptoreihin sitoutuvan analogin pasireotidin on osoitettu olevan tehokkaampi kuin kasvua inhibiittorianalogit, kuten oktreotidi ja lanreotidi, akromegalian, karsinoidikasvaimien ja Cushingin taudin hoidossa sek\u00e4 prekliinisiss\u00e4 kokeissa, kuten solutesteiss\u00e4 ja el\u00e4intutkimuksissa, sek\u00e4 kliiniset tutkimukset. Pasireotidilla tehdyn faasin II tutkimuksen ja yhden vaiheen III tutkimuksen tulokset ovat vahvistaneet, ett\u00e4 pasireotidi on uusi hoito uusille tai jatkuville akromegalialle ja metastaattisille karsinoidikasvaimille, ja se voi olla ensimm\u00e4inen l\u00e4\u00e4kehoitovaihtoehto Cushingin taudin hoitoon.<\/p>\n","protected":false},"excerpt":{"rendered":"

Tuotteen nimi: PASIREOTIDE
\nMF: C58H66N10O9
\nMW: 1047.23
\nEINECS:
\nMol Tiedosto: 396091-73-9.mol<\/p>\n","protected":false},"featured_media":2205,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[532],"product_tag":[1241],"class_list":{"0":"post-8415","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-muut-peptidit","7":"product_tag-hot-sale-pharmaceutical-peptidespasireotide-cas-396091-73-9-fi","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product\/8415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/comments?post=8415"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/media\/2205"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/media?parent=8415"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_brand?post=8415"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_cat?post=8415"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_tag?post=8415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}