{"id":8578,"date":"2021-12-17T01:47:32","date_gmt":"2021-12-17T06:47:32","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/nesiritide-bnp-32-human-cas-124584-08-3-aivojen-natriureettinen-peptidi-sydamen-vajaatoimintaan\/"},"modified":"2021-12-17T01:47:32","modified_gmt":"2021-12-17T06:47:32","slug":"nesiritide-bnp-32-human-cas-124584-08-3-aivojen-natriureettinen-peptidi-sydamen-vajaatoimintaan","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fi\/product\/nesiritide-bnp-32-human-cas-124584-08-3-aivojen-natriureettinen-peptidi-sydamen-vajaatoimintaan\/","title":{"rendered":"Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Aivojen natriureettinen peptidi syd\u00e4men vajaatoimintaan"},"content":{"rendered":"

Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3 Aivojen natriureettinen peptidi syd\u00e4men vajaatoimintaan<\/strong><\/h2>\n

Tuotteen nimi: Nesiritide \/ BNP-32 (IHMINEN)
\nSynonyymit: Nesiritide,Brain Natriuretic Peptide-32 human,BNP-32,>98%;BNP-32 (ihmis)hydrokloridi;nesiritidi [USAN:INN] ;SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (DISULFIDISILTA: 10-26);SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER -SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS;H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY -ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH;H-SER-PRO-LYS -MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL -LEU-ARG-ARG-HIS-OH (DISULFIDISILTA: 10-26);aivojen NATRIUREETTINEN PEPTIDI (1-32), IHMISEN
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nTuoteluokat:
\nMol-tiedosto: 124584-08-3.mol<\/p>\n

Nesiritidi otettiin k\u00e4ytt\u00f6\u00f6n Yhdysvalloissa uutena suonensis\u00e4isen\u00e4 hoitona potilaille, joilla on akuutisti dekompensoitunut kongestiivinen syd\u00e4men vajaatoiminta, joilla on hengenahdistusta levossa tai v\u00e4h\u00e4isell\u00e4 aktiivisuudella ity. Nesiritidi on voimakkaan verisuonia laajentavan B-tyypin natriureettisen peptidin (tunnetaan my\u00f6s nimell\u00e4 aivojen natriureettinen peptidi), luonnossa esiintyv\u00e4 32 aminohapon peptidi, jolla on disulfidisidottu 17 aminohapon rengasrakenne, ensimm\u00e4inen ihmisen rekombinanttimuoto. Nesiritidi sitoutuu Atypen natriureettiseen peptidireseptoriin endoteelisolujen ja sileiden lihassolujen pinnalla stimuloiden toisen l\u00e4hetti-cGMP:n tuotantoa, joka v\u00e4litt\u00e4\u00e4 p\u00e4\u00e4asiassa verisuonten sile\u00e4n lihaksen solujen rentoutumista. Se my\u00f6s helpottaa natriumin ja veden poistumista munuaisista ja v\u00e4hent\u00e4\u00e4 tiettyjen hormonien, kuten adrenaliinin, angiotensiini II:n, aldosteronin ja endoteliinin, erityst\u00e4, mik\u00e4 aiheuttaa pitk\u00e4aikaisia haitallisia vaikutuksia, kuten verisuonten supistumista ja verenpaineen nousua. Kliinisiss\u00e4 tutkimuksissa syd\u00e4men vajaatoimintapotilailla nesididi alensi annoksesta riippuvaisesti keuhkokapillaarin painetta, oikean eteisen painetta ja systeemist\u00e4 verisuonivastusta sek\u00e4 suurensi syd\u00e4nindeksi\u00e4 ilman, ett\u00e4 se vaikutti sykeen. Suurin havaittu haittavaikutus oli annoksesta riippuvainen hypotensio. Vaiheen III vertailututkimuksessa nesiritidin todettiin olevan parempi kuin iv. nitroglyseriini\u00e4 sen hemodynaamisissa vaikutuksissa sek\u00e4 helpompi antaa ja paremmin siedetty. Nesiritidi puhdistuu proteolyyttisell\u00e4 pilkkoutumisella neutraalin endopeptidaasin NEP24.11 toimesta ja sitoutumalla C-tyypin natriureettiseen peptidireseptoriin, mit\u00e4 seuraa endosytoosi ja solunsis\u00e4inen lysosomaalinen hydrolyysi. Koska nesiritidill\u00e4 on lyhyt puoliintumisaika (18 min), se annetaan 21 \u03bcg\/kg bolusinfuusiona, jota seuraa jatkuva yll\u00e4pitoinfuusio 0,011 \u03bcg\/kg\/min, yleens\u00e4 24-48 tunnin aikana.<\/p>\n

Nesiritidi \/ BNP-32 (HUMAN) CAS 124584-08-3 Kemialliset ominaisuudet<\/strong>
\nBNP-32 (IHMINEN) Kemialliset ominaisuudet
\ntiheys 1,52\u00b10,1 g\/cm3 (ennustettu)
\nRTECS EE1534000
\nvarastointil\u00e4mp\u00f6tila. \u221220\u00b0C
\njauhemainen
\nVesiliukoisuus Liukenee veteen 1 mg\/ml
\nCAS-tietokannan viite 124584-08-3<\/p>\n

Nesiritidin \/ BNP-32 (ihminen) toiminta ja k\u00e4ytt\u00f6 CAS 124584-08-3<\/strong>
\nCongestiivisen syd\u00e4men vajaatoiminnan hoito (reniini-angiotensiinij\u00e4rjestelm\u00e4n antagonisti).<\/p>\n","protected":false},"excerpt":{"rendered":"

Tuotteen nimi: Nesiritide \/ BNP-32 (HUMAN)
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4 Kate&>Tuote: &>Mol Tiedosto: 124584-08-3.mol<\/p>\n","protected":false},"featured_media":2289,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[494],"product_tag":[1138],"class_list":{"0":"post-8578","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-sydan-ja-verisuonijarjestelman-peptidi","7":"product_tag-nesiritide-bnp-32-human-cas-124584-08-3-brain-natriuretic-peptide-for-heart-failure-fi","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product\/8578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/comments?post=8578"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/media\/2289"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/media?parent=8578"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_brand?post=8578"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_cat?post=8578"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fi\/wp-json\/wp\/v2\/product_tag?post=8578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}