{"id":7264,"date":"2021-12-16T07:20:05","date_gmt":"2021-12-16T12:20:05","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/enfuvirtide-acetate-denfuvirtide-cas-159519-65-0-pour-lanti-vih\/"},"modified":"2021-12-16T07:20:05","modified_gmt":"2021-12-16T12:20:05","slug":"enfuvirtide-acetate-denfuvirtide-cas-159519-65-0-pour-lanti-vih","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fr\/product\/enfuvirtide-acetate-denfuvirtide-cas-159519-65-0-pour-lanti-vih\/","title":{"rendered":"Enfuvirtide\/ac\u00e9tate d'Enfuvirtide CAS 159519-65-0 pour l'anti VIH"},"content":{"rendered":"

Enfuvirtide\/ac\u00e9tate d'Enfuvirtide CAS 159519-65-0 pour l'anti VIH<\/strong><\/h2>\n

Nom du produit\u00a0: Enfuvirtide
\nS\u00e9quence\u00a0: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys< &>-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\nSynonymes : Enfuvirtide; T-2;Enfuvirtide Ac\u00e9tate (T-20);ENFUVIRTIDE(T-20) 98+%;Enfurvitide(T-20);Pentafuside;Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH{2};Enfuvirtide;Aids059486
\nCAS\u00a0: 159519-65-0
\nMF\u00a0: C204H301N51O64
\nMW\u00a0: 4491.92
\nEINECS\u00a0: 641-385-0
\nCat\u00e9gories de produits : proteines;Peptide
\nMol File: 159519-65-0.mol<\/p>\n

C'est un inhibiteur peptidique synth\u00e9tique de la fusion du VIH, qui peut se lier \u00e0 la glycoprot\u00e9ine de l'enveloppe virale et emp\u00eacher les changements de conformation n\u00e9cessaires au virus fusionner avec la membrane cellulaire, inhibant ainsi la r\u00e9plication du VIH-1. Le peptide d'Enfevir est d\u00e9riv\u00e9 d'une s\u00e9quence d'acides amin\u00e9s naturelle dans le domaine HR2 de gp41. En simulant l'activit\u00e9 du domaine HR2 et en se liant de mani\u00e8re comp\u00e9titive au domaine HR1 de la gp41, le peptide Enfevir emp\u00eache l'interaction entre HR1 et HR2 et les changements de configuration de la Gp41, emp\u00eachant ainsi la fusion du virus avec les cellules h\u00f4tes.<\/p>\n

L'enfuvirtide est le premier d'une nouvelle classe de th\u00e9rapies contre le VIH qui interf\u00e8re avec l'entr\u00e9e du VIH-1 en inhibant la fusion des membranes virales et cellulaires. Il se lie \u00e0 la premi\u00e8re r\u00e9p\u00e9tition heptadique (HR1) dans la sous-unit\u00e9 ghe gp41 de la glycoprot\u00e9ine d'enveloppe virale et emp\u00eache les changements de conformation n\u00e9cessaires \u00e0 la fusion avec les membranes cellulaires, repr\u00e9sentant ainsi un nouveau m\u00e9canisme. C'est un puissant inhibiteur de cette liaison avec une CI50 en laboratoire et des isolats primaires (VIH-1 clades A\u2013G) allant de 4 \u00e0 280 nM (18\u20131260 ng\/mL), mais n'a pratiquement aucune activit\u00e9 contre le VIH-2. En raison de son m\u00e9canisme unique, il ne pr\u00e9sente pas de r\u00e9sistance crois\u00e9e aux INTI, NNRTI et IP. Il est pr\u00e9par\u00e9 par synth\u00e8se chimique, en utilisant une combinaison d'\u00e9tapes en solution et en phase solide. Les \u00e9tapes en phase solide utilisent la protection fmoc et la r\u00e9sine de chlorure de 2-chlorotrityle sensible aux acides pour produire des peptides de longueurs allant de neuf \u00e0 seize acides amin\u00e9s. <\/p>\n

Enfuvirtide\/ ac\u00e9tate d'Enfuvirtide CAS 159519-65-0 Propri\u00e9t\u00e9s chimiques<\/strong>
\n temp\u00e9rature de stockage. -20\u00b0C
\nforme de poudre
\ncouleur blanc \u00e0 blanc cass\u00e9<\/p>\n

Utilisations d'Enfuvirtide\/Enfuvirtide Acetate CAS 159519-65-0<\/strong>
\nIl est utilis\u00e9 en combinaison avec des m\u00e9dicaments de la transcriptase inverse pour l'homme infection par le virus de l'immunod\u00e9ficience (VIH).<\/p>\n","protected":false},"excerpt":{"rendered":"

Nom du produit : Enfuvirtide
\nCAS : 159519-65-0
\nMF : C204H301N51O64
\nMW : 4491.92
\nEINECS : 641-385-0
\nMol Fichier : 159519-65-0.mol<\/p>\n","protected":false},"featured_media":2122,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[526],"product_tag":[2502],"class_list":{"0":"post-7264","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-autres-peptides","7":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-fr","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product\/7264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/comments?post=7264"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media\/2122"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media?parent=7264"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_brand?post=7264"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_cat?post=7264"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_tag?post=7264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}