{"id":8098,"date":"2021-12-16T12:17:41","date_gmt":"2021-12-16T17:17:41","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/traiter-lacetate-de-ziconotide-cas-107452-89-1-pour-la-nevralgie-post-zosterienne-et-la-douleur-cancereuse\/"},"modified":"2021-12-16T12:17:41","modified_gmt":"2021-12-16T17:17:41","slug":"traiter-lacetate-de-ziconotide-cas-107452-89-1-pour-la-nevralgie-post-zosterienne-et-la-douleur-cancereuse","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fr\/product\/traiter-lacetate-de-ziconotide-cas-107452-89-1-pour-la-nevralgie-post-zosterienne-et-la-douleur-cancereuse\/","title":{"rendered":"Traiter l'ac\u00e9tate de ziconotide CAS 107452-89-1 pour la n\u00e9vralgie post-zost\u00e9rienne et la douleur canc\u00e9reuse"},"content":{"rendered":"

Traiter l'ac\u00e9tate de ziconotide CAS 107452-89-1 pour la n\u00e9vralgie post-zost\u00e9rienne et la douleur canc\u00e9reuse<\/strong><\/h2>\n

Nom du produit\u00a0: Ac\u00e9tate de ziconotide
\nSynonymes\u00a0: OMEGA-CONOTOXIN MVIIA;OMEGA-CGTX MVII A;ACETATE DE ZICONOTIDE;snx111;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG -LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS -SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (PONT DISULFURE\u00a0: 1-16, 8-20 ET 15 -25);CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY- LYS-CYS-NH2;CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (PONT DISULFURE\u00a0: 1-16,8-20 ET 15-25)
\nCAS\u00a0: 107452-89-1
\nMF\u00a0: C102H172N36O32S7
\nMW\u00a0: 2639.13<& >EINECS :
\nCat\u00e9gories de produits : Peptide
\nMol File : 107452-89-1.mol<\/p>\n

Ziconotide (Prialt) est un compos\u00e9 de 25 acides amin\u00e9s, trois toxine peptidique \u00e0 pont disulfure d\u00e9riv\u00e9 du Sud Escargot marin du Pacifique Conusmagus. Il s'agit du premier nouvel agent neuroth\u00e9rapeutique – bloqueur des canaux calciques de type N (NCCB). Il agit s\u00e9lectivement sur les canaux calciques \u00e9lectrosensibles de type N de Chemicalbook dans les branches terminales dendritiques et axonales, inhibant ainsi les aff\u00e9rences de stimulus initial de blessure. Il est indiqu\u00e9 chez les patients souffrant de douleurs chroniques s\u00e9v\u00e8res qui n\u00e9cessitent un traitement intrath\u00e9cal et qui sont intol\u00e9rants ou peu efficaces aux autres traitements analg\u00e9siques (par exemple, application d'analg\u00e9siques syst\u00e9miques ou de morphine intrath\u00e9cale). Le ziconotide intrath\u00e9cal peut \u00eatre utilis\u00e9 pour traiter la n\u00e9vralgie post-zost\u00e9rienne, la douleur du membre fant\u00f4me, la douleur neuropathique li\u00e9e au VIH, la douleur canc\u00e9reuse r\u00e9fractaire et la douleur post-chirurgicale.<\/p>\n

Ac\u00e9tate de ziconotide CAS 107452-89-1 Propri\u00e9t\u00e9s chimiques<\/strong>
\n densit\u00e9 1,60\u00b10,1 g\/cm3 (pr\u00e9vu)
\ntemp\u00e9rature de stockage. -20\u00b0C
\nInChIKey BPKIMPVREBSLAJ-QTBYCLKRSA-N<\/p>\n

Utilisations de l'ac\u00e9tate de ziconotide CAS 107452-89-1<\/strong>
\nLigand pour les \u00e9tudes de liaison des canaux calciques sensibles au voltage.<\/p>\n

Ziconotide ( SNX-111; Prialt), \u00e9galement appel\u00e9 ziconotide intrath\u00e9cal (ITZ) en raison de sa voie d'administration, est un agent analg\u00e9sique atypique pour l'am\u00e9lioration de la douleur s\u00e9v\u00e8re et chronique. D\u00e9riv\u00e9 de Conus magus, un escargot conique, c'est la forme synth\u00e9tique d'un peptide -conotoxine.[1] Il est 1 000 fois plus puissant que la morphine.<\/p>\n

Ce produit convient aux patients souffrant de douleurs chroniques s\u00e9v\u00e8res qui n\u00e9cessitent un traitement intrath\u00e9cal et qui sont intol\u00e9rants ou peu efficaces aux autres traitements antalgiques (comme l'application d'antalgiques syst\u00e9miques ou injection intrath\u00e9cale de morphine, etc.).<\/p>\n

Fonction et application de l'ac\u00e9tate de ziconotide CAS 107452-89-1<\/strong>
\n1. Efficacit\u00e9 analg\u00e9sique Le ziconotide convient aux patients souffrant de douleur chronique qui ne tol\u00e8rent pas ou ne r\u00e9pondent pas aux autres traitements, y compris les m\u00e9dicaments syst\u00e9miques, le traitement adjuvant de l'injection intrath\u00e9cale de morphine. L'injection intrath\u00e9cale de ziconotide a une efficacit\u00e9 analg\u00e9sique cliniquement et statistiquement significative chez les patients atteints de cancer ou du SIDA.<\/p>\n

2. Protection de la moelle \u00e9pini\u00e8re Isch\u00e9mie \u00e0 court terme de la moelle \u00e9pini\u00e8re Lorsque les neurones de la moelle \u00e9pini\u00e8re sont endommag\u00e9s, il y a activation de la voie \u00e9lectrosensible du calcium de type N. Le ziconotide peut fournir une neuroprotection et une analg\u00e9sie pendant la chirurgie aortique.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nom du produit : Ac\u00e9tate de ziconotide
\nCAS : 107452-89-1
\nMF : C102H172N36O32S7
\nMW : 2639.13
\nMol Dossier : 107452-89-1.mol<\/p>\n","protected":false},"featured_media":2206,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[],"product_tag":[1582],"class_list":{"0":"post-8098","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_tag-ziconotide-acetate-cas-107452-89-1-treat-for-postherpetic-neuralgia-and-cancer-pain-fr","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product\/8098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/comments?post=8098"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media\/2206"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media?parent=8098"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_brand?post=8098"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_cat?post=8098"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_tag?post=8098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}