{"id":8156,"date":"2021-12-16T12:21:06","date_gmt":"2021-12-16T17:21:06","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/acetate-de-vapreotide-rc-160-cas-103222-11-3-traitement-pour-le-saignement-variqueux-oesophagien-aigu\/"},"modified":"2021-12-16T12:21:06","modified_gmt":"2021-12-16T17:21:06","slug":"acetate-de-vapreotide-rc-160-cas-103222-11-3-traitement-pour-le-saignement-variqueux-oesophagien-aigu","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fr\/product\/acetate-de-vapreotide-rc-160-cas-103222-11-3-traitement-pour-le-saignement-variqueux-oesophagien-aigu\/","title":{"rendered":"Ac\u00e9tate de Vapreotide\/RC 160 CAS 103222-11-3 Traitement pour le saignement variqueux oesophagien aigu"},"content":{"rendered":"

Ac\u00e9tate de Vapreotide\/RC 160 CAS 103222-11-3 Traitement pour le saignement variqueux oesophagien aigu<\/strong><\/h2>\n

Nom du produit\u00a0: VAPREOTIDE
\nSynonymes\u00a0: D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (pont disulfure Cys2-Cys7)\u00a0;HD-Phe-Cys-Tyr-D -Trp-Lys-Val-Cys-Trp-NH2\u00a0; D-Phe-Cys-Trp-D-Trp-Lys-Val-Cys-Trp-CONH2 (disulfure Cys2-Cys7)\u00a0; Vapr\u00e9otide, RC-160\u00a0; RC-160 ;VAPREOTIDE;D-PHE-CYS-TYR-D-TRP-LYS-VAL-CYS-TRP-NH2;FCYWKVCW-NH2
\nCAS : 103222-11-3
\nMF : C57H70N12O9S2
\nMW : 1131.37
\nEINECS\u00a0:
\nCat\u00e9gories de produits\u00a0: r\u00e9cepteur de la somatostatine
\nFichier Mol\u00a0: 103222-11-3.mol<\/p>\n

H3Pharma a acquis la licence mondiale de recherche-d\u00e9veloppement et commerciale pour le vaptan de Debiopharm en Suisse. 2001 New England Journal of Medicine a rapport\u00e9 la formulation \u00e0 lib\u00e9ration imm\u00e9diate, qui a \u00e9t\u00e9 test\u00e9e cliniquement et prouv\u00e9e par Chemicalbook pour une utilisation pr\u00e9coce dans le traitement de l'\u0153sophage aigu En 2004, la filiale de Debiopharm, le sp\u00e9cialiste canadien du cancer et de l'endocrinologie H3Pharma, a d\u00e9velopp\u00e9 et fabriqu\u00e9 un nouveau m\u00e9dicament .<\/p>\n

Ac\u00e9tate de vapr\u00e9otide\/ RC 160 CAS 103222-11-3 Propri\u00e9t\u00e9s chimiques<\/strong>
\nPoint d'\u00e9bullition 1540.9\u00b165.0 \u00b0C(Predicted)
\ndensit\u00e9 1,40\u00b10,1 g\/cm3(Predicted)
\nstockage temp. \u221220\u00b0C
\npka 9.90\u00b10.15(Predicted)<\/p>\n

Fonction et application de l'ac\u00e9tate de vapr\u00e9otide\/ RC 160 CAS 103222-11-3<\/strong>
\n1.La formulation \u00e0 lib\u00e9ration imm\u00e9diate de Sanvar, un analogue de la somatostatine , est utilis\u00e9 dans le traitement des h\u00e9morragies variqueuses aigu\u00ebs de l'\u0153sophage (EVB).
\n2.Sanvar est utilis\u00e9 avant une intervention endoscopique pour contr\u00f4ler l'h\u00e9morragie et pr\u00e9venir les r\u00e9cidives h\u00e9morragiques pendant les cinq jours critiques suivant le d\u00e9but de l'h\u00e9morragie. L'EVB est une maladie potentiellement mortelle et le taux de mortalit\u00e9 est \u00e9lev\u00e9 (environ 15 % \u00e0 25 %) au cours des six premi\u00e8res semaines suivant l'h\u00e9morragie. L'EVB est \u00e0 l'origine d'environ 70\u00a0% des saignements gastro-intestinaux chez les patients souffrant de cirrhose du foie.
\n3.Sanvar (ac\u00e9tate de vapr\u00e9otide) est un analogue octapeptide synth\u00e9tique de l'hormone somatostatine naturelle. Il a des propri\u00e9t\u00e9s pharmacologiques similaires \u00e0 la somatostatine native, mais pr\u00e9sente une dur\u00e9e d'action plus longue. C'est le seul analogue de la somatostatine \u00e0 avoir d\u00e9montr\u00e9 des b\u00e9n\u00e9fices statistiquement significatifs dans le traitement pr\u00e9coce de l'EVB en association avec un traitement endoscopique, dans une \u00e9tude clinique contr\u00f4l\u00e9e versus placebo (Cal\u00e8s et al. New England Journal of Medicine, 2001). Le contr\u00f4le des saignements avec survie \u00e0 cinq jours a \u00e9t\u00e9 obtenu plus souvent avec Sanvar (p=0,021) qu'avec le placebo. Suppl\u00e9mentaire<\/p>\n","protected":false},"excerpt":{"rendered":"

Nom du produit : VAPREOTIDE
\nCAS : 103222-11-3
\nMF : C57H70N12O9S2
\nMW : 1131.37
\nMol Dossier : 103222-11-3.mol<\/p>\n","protected":false},"featured_media":2122,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[526],"product_tag":[1541],"class_list":{"0":"post-8156","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-autres-peptides","7":"product_tag-vapreotide-acetate-rc-160-cas-103222-11-3-treatment-for-acute-esophageal-variceal-bleeding-fr","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product\/8156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/comments?post=8156"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media\/2122"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media?parent=8156"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_brand?post=8156"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_cat?post=8156"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_tag?post=8156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}