{"id":8303,"date":"2021-12-16T13:22:10","date_gmt":"2021-12-16T18:22:10","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/acetate-de-somatostatine-peptidique-de-haute-qualite-15-28-somatostatine-28-cas-38916-34-6\/"},"modified":"2021-12-16T13:22:10","modified_gmt":"2021-12-16T18:22:10","slug":"acetate-de-somatostatine-peptidique-de-haute-qualite-15-28-somatostatine-28-cas-38916-34-6","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fr\/product\/acetate-de-somatostatine-peptidique-de-haute-qualite-15-28-somatostatine-28-cas-38916-34-6\/","title":{"rendered":"Ac\u00e9tate de somatostatine peptidique de haute qualit\u00e9\/15-28-Somatostatine-28 CAS 38916-34-6"},"content":{"rendered":"

Ac\u00e9tate de somatostatine peptidique de haute qualit\u00e9\/15-28-Somatostatine-28 CAS 38916-34-6<\/strong><\/h2>\n

Nom du produit\u00a0: Ac\u00e9tate de somatostatine\/ 15-28-Somatostatine-28
\nSynonymes\u00a0: Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH ; Facteur d'inhibition de la lib\u00e9ration de la SoMatotrophine, SRIF, SRIF-14\u00a0; Somatostatine cyclique\u00a0; Ac\u00e9tate de la SoMatostatine\u00a0; Facteur d'inhibition de la lib\u00e9ration d'hormones de croissance (HUMAIN, OVIN, PORCIN, RAT, SOURIS); SOURIS) 2ACOH 6H2O;H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH;H-ALA-GLY-CYS-LYS-ASN-PHE -PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (COUPL\u00c9 \u00c0 BSA)
\nCAS : 38916-34-6
\nMF : C76H104N18O19S2
\nMW : 1637.88
\nEINECS : 254-186-5
\nCat\u00e9gories de produits : D\u00e9riv\u00e9s d'acides amin\u00e9s;Acides amin\u00e9s et d\u00e9riv\u00e9s;Peptide;Acides amin\u00e9s 13C, 2H, 15N;Interm\u00e9diaires et chimie fine;Pharmaceutique;peptides pharm
\nMol File: 38916-34-6 .mol<\/p>\n

La somatostatine est un 14-peptide cyclique qui a \u00e9t\u00e9 isol\u00e9 pour la premi\u00e8re fois par Guillemin en 1973 et est probablement le plus \u00e9tudi\u00e9 et le plus important des facteurs inhibiteurs produits par l'hypotha lamus. L'activit\u00e9 principale de la somatostatine, qui est d'origine hypothalamique, est l'inhibition de la lib\u00e9ration de l'hormone de croissance (GH) par l'hypophyse ant\u00e9rieure. Trop de GH, comme dans les tumeurs hypophysaires, provoque l'acrom\u00e9galie, une forme de gigantisme. D'autre part, trop peu de GH conduit au nanisme. La somatostatine a \u00e9galement \u00e9t\u00e9 trouv\u00e9e dans le pancr\u00e9as et le tractus gastro-intestinal, o\u00f9 elle inhibe la s\u00e9cr\u00e9tion d'insuline et de glucagon par le pancr\u00e9as ainsi que la s\u00e9cr\u00e9tion d'une vari\u00e9t\u00e9 de peptides intestinaux (par exemple, gastrine, s\u00e9cr\u00e9tine, pepsine et r\u00e9nine). La courte demi-vie de la somatostatine, inf\u00e9rieure \u00e0 3 minutes, a emp\u00each\u00e9 son utilisation comme agent th\u00e9rapeutique. De nombreux d\u00e9riv\u00e9s de la somatostatine ont \u00e9t\u00e9 pr\u00e9par\u00e9s pour augmenter sa dur\u00e9e d'action et\/ou pour augmenter sa s\u00e9lectivit\u00e9 d'action. Le point culminant de ces \u00e9tudes structure-activit\u00e9 a \u00e9t\u00e9 le d\u00e9veloppement de l'ac\u00e9tate d'octr\u00e9otide.<\/p>\n

En plus de l'hypothalamus, d'autres parties telles que le cortex c\u00e9r\u00e9bral, le striatum, l'amygdale, l'hippocampe et la moelle \u00e9pini\u00e8re, le nerf sympathique, gastro-intestinal, les \u00eelots, les reins, la thyro\u00efde et les glandes parathyro\u00efdes sont largement distribu\u00e9s dans la somatostatine. Dans le cerveau et le tractus gastro-intestinal, 28 acides amin\u00e9s de GHRIH28, qui est une extension vers l'ext\u00e9rieur de l'extr\u00e9mit\u00e9 N-terminale de GHRIH14, ont \u00e9t\u00e9 purifi\u00e9s. L'effet de la somatostatine in vitro est compliqu\u00e9, et il peut agir comme un transmetteur ou moduler dans le syst\u00e8me nerveux ; la somatostatine a un certain effet inhibiteur sur la motilit\u00e9 gastro-intestinale et la s\u00e9cr\u00e9tion d'hormones du tube digestif; il inhibe \u00e9galement la s\u00e9cr\u00e9tion d'insuline et de pancr\u00e9as, de glucagon, de r\u00e9nine, d'hormone parathyro\u00efdienne et de calcitonine.<\/p>\n

Ac\u00e9tate de somatostatine\/15-28-Somatostatine-28 CAS 38916-34-6 Propri\u00e9t\u00e9s chimiques<\/strong>
\n15-28-Somatostatine-28 Propri\u00e9t\u00e9s chimiques
\nPoint d'\u00e9bullition 1970,9\u00b165,0 \u00b0C(Pr\u00e9vu)
\ndensit\u00e9 1,43\u00b10,1 g\/cm3(Pr\u00e9vu)
\ntemp\u00e9rature de stockage. \u221220\u00b0C
\nsolubilit\u00e9 H2O\u00a0: 1 mg\/mL
\npka 2.94\u00b10.70(Predicted)
\nform powder
\nWater Solubilit\u00e9 Soluble in water(25,00\u00b0C 1,00 g\/L) , M\u00e9thanol.
\nMerck 13,8788
\nBRN 6436064
\nInChIKey NHXLMOGPVYXJNR-ATOGVRKGSA-N<\/p>\n

Fonction et application de l'ac\u00e9tate de somatostatine\/15-28-Somatostatine-28 CAS<\/strong> <& >
\n1 Il peut inhiber la s\u00e9cr\u00e9tion d'hormone de croissance, d'hormone thyr\u00e9ostimulante, d'insuline, de glucagon.<\/p>\n

2 Il peut inhiber la s\u00e9cr\u00e9tion d'acide gastrique stimul\u00e9e par le repas test et la gastrine \u00e0 5 peptides, et peut inhiber la lib\u00e9ration de pepsine et de gastrine.<\/p>\n

3 Il peut r\u00e9duire consid\u00e9rablement le d\u00e9bit sanguin visc\u00e9ral, r\u00e9duire la pression portale, r\u00e9duire le d\u00e9bit sanguin et la pression de la circulation collat\u00e9rale, r\u00e9duire le d\u00e9bit sanguin h\u00e9patique.<\/p>\n

4 Il r\u00e9duit la s\u00e9cr\u00e9tion du pancr\u00e9as et la s\u00e9cr\u00e9tion de l'intestin gr\u00eale et de la v\u00e9sicule biliaire, r\u00e9duisent l'activit\u00e9 enzymatique et ont un effet protecteur sur les cellules pancr\u00e9atiques.<\/p>\n

5 Cela peut affecter l'absorption et la fonction nutritionnelle du tractus gastro-intestinal.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nom du produit\u00a0: Ac\u00e9tate de somatostatine\/ 15-28-Somatostatine-28
\nCAS\u00a0: 38916-34-6
\nMF\u00a0: C76H104N18O19S2
\nMW\u00a0: 1637.88
\nEINECS\u00a0: 254-186-5
\nMol File : 38916-34-6.mol<\/p>\n","protected":false},"featured_media":2122,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[],"product_tag":[],"class_list":{"0":"post-8303","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"desktop-align-left","7":"tablet-align-left","8":"mobile-align-left","10":"first","11":"instock","12":"shipping-taxable","13":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product\/8303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/comments?post=8303"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media\/2122"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media?parent=8303"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_brand?post=8303"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_cat?post=8303"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_tag?post=8303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}