{"id":8418,"date":"2021-12-16T13:28:06","date_gmt":"2021-12-16T18:28:06","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/vente-chaude-peptides-pharmaceutiques-pasireotide-cas-396091-73-9\/"},"modified":"2021-12-16T13:28:06","modified_gmt":"2021-12-16T18:28:06","slug":"vente-chaude-peptides-pharmaceutiques-pasireotide-cas-396091-73-9","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fr\/product\/vente-chaude-peptides-pharmaceutiques-pasireotide-cas-396091-73-9\/","title":{"rendered":"Vente chaude Peptides pharmaceutiques Pasireotide CAS 396091-73-9"},"content":{"rendered":"

Vente chaude Peptides pharmaceutiques Pasireotide CAS 396091-73-9<\/strong><\/h2>\n

Nom du produit\u00a0: PASIREOTIDE
\nSynonymes\u00a0: PASIREOTIDE;Cyclo[(2S)-2-ph\u00e9nylglycyl-D-tryptophyl-L-lysyl-O-(ph\u00e9nylm\u00e9thyl)-L-tyrosyl-L-ph\u00e9nylalanyl-(4R)- 4-[[[(2-amino\u00e9thyl)amino]carbonyl]oxy]-L-prolyl];SOM 230;SOM 320;[(3S,6S,9S,12R,15S,18S,20R)-9-(4- aminobutyl)-3-benzyl-12-(1H-indol-3-ylm\u00e9thyl)-2,5,8,11,14,17-hexaoxo-15-ph\u00e9nyl-6-[(4-ph\u00e9nylm\u00e9thoxyph\u00e9nyl)m\u00e9thyl]-1, 4,7,10,13,16-hexazabicyclo[16.3.0]henicosan-20-yl] N-(2-amino\u00e9thyl)carbamate;SOM 230;SOM 320;CYCLO((4R)-4-(2-AMINOETHYLCARBAMOYLOXY) -L-PROLYL-L-PHENYLGLYCYL-D-TRYPTOPHYL-L-LYSYL-4-O-BENZYL-L-TYROSYL-L-PHENYLALANYL-)
\nCAS : 396091-73-9
\nMF : C58H66N10O9<& >MW\u00a0: 1047.23
\nEINECS\u00a0:
\nCat\u00e9gories de produits\u00a0:
\nFichier Mol\u00a0: 396091-73-9.mol<\/p>\n

En avril 2012, la Commission europ\u00e9enne a approuv\u00e9 le pasir\u00e9otide pour le traitement de la maladie de Cushing ( MC) chez les patients adultes qui n'ont pas r\u00e9pondu \u00e0 une intervention chirurgicale ou pour lesquels la chirurgie n'est pas une option. Le pasir\u00e9otide a \u00e9t\u00e9 approuv\u00e9 pour la m\u00eame indication par la FDA des \u00c9tats-Unis en d\u00e9cembre 2012. Le pasir\u00e9otide (\u00e9galement k maintenant appel\u00e9 SOM230) est un cyclohexapeptide qui agit comme un analogue de la somatostatine pour inhiber la lib\u00e9ration d'ACTH. Les somatostatines sont des peptides cycliques de 14 et 28 acides amin\u00e9s qui jouent un r\u00f4le important dans la r\u00e9gulation de la lib\u00e9ration endocrinienne et exocrine dans de nombreux tissus par le biais d'un m\u00e9canisme inhibiteur. Il existe cinq sous-types connus de r\u00e9cepteurs de la somatostatine (SSTR). Les somatostatines naturelles se lient avec une grande affinit\u00e9 aux cinq sous-types, cependant, leur utilisation th\u00e9rapeutique est limit\u00e9e par une d\u00e9gradation rapide dans le plasma. Le pasir\u00e9otide est n\u00e9 des efforts pour identifier un somatostatinmim\u00e9tique avec des effets inhibiteurs de longue dur\u00e9e. En commen\u00e7ant par un peptide de somatostatine de 14 acides amin\u00e9s, une analyse syst\u00e9matique de l'alanine a r\u00e9v\u00e9l\u00e9 des r\u00e9sidus essentiels \u00e0 la liaison du sous-type de r\u00e9cepteur, y compris les r\u00e9gions cl\u00e9s du virage b et les r\u00e9sidus adjacents. Le placement des \u00e9l\u00e9ments structurels cl\u00e9s en tant qu'acides amin\u00e9s non naturels dans un squelette cyclohexapeptidique a donn\u00e9 du pasir\u00e9otide.<\/p>\n

PASIREOTIDE CAS 396091-73-9<\/strong>
\nPoint d'\u00e9bullition 1351,4\u00b165,0 \u00b0C (pr\u00e9vu)
\ndensit\u00e9 1,36\u00b10,1 g \/cm3(Predicted)
\npka 11,86\u00b10.46(Predicted)
\nCAS DataBase Reference 396091-73-9<\/p>\n

Fonction et application de PASIREOTIDE CAS 396091-73-9<\/strong>
\nEn tant qu'inhibiteur de croissance analogue qui se lie \u00e0 de multiples r\u00e9cepteurs, le pasir\u00e9otide s'est av\u00e9r\u00e9 plus efficace que les analogues inhibiteurs de croissance tels que l'octr\u00e9otide et le lanr\u00e9otide dans le traitement de l'acrom\u00e9galie, des tumeurs carcino\u00efdes et de la maladie de Cushing, \u00e0 la fois dans des essais pr\u00e9cliniques tels que des tests cellulaires et des \u00e9tudes animales, et dans essais cliniques. Les r\u00e9sultats de l'essai de phase II et d'un essai de phase III sur le pasir\u00e9otide ont confirm\u00e9 que le pasir\u00e9otide est un nouveau traitement pour l'acrom\u00e9galie nouvelle ou persistante et les tumeurs carcino\u00efdes m\u00e9tastatiques, et peut \u00eatre le premier choix de traitement m\u00e9dicamenteux pour la maladie de Cushing.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nom du produit : PASIREOTIDE
\nMF : C58H66N10O9
\nMW : 1047.23
\nEINECS :
\nMol Dossier : 396091-73-9.mol<\/p>\n","protected":false},"featured_media":2206,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[526],"product_tag":[1244],"class_list":{"0":"post-8418","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-autres-peptides","7":"product_tag-hot-sale-pharmaceutical-peptidespasireotide-cas-396091-73-9-fr","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product\/8418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/comments?post=8418"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media\/2206"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media?parent=8418"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_brand?post=8418"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_cat?post=8418"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_tag?post=8418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}