{"id":8945,"date":"2021-12-17T03:38:47","date_gmt":"2021-12-17T08:38:47","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/linaclotide-cas-851199-59-2-pour-traiter-le-syndrome-du-colon-irritable-constipe-sci-c-et-la-constipation-idiopathique-chronique-cic\/"},"modified":"2021-12-17T03:38:47","modified_gmt":"2021-12-17T08:38:47","slug":"linaclotide-cas-851199-59-2-pour-traiter-le-syndrome-du-colon-irritable-constipe-sci-c-et-la-constipation-idiopathique-chronique-cic","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/fr\/product\/linaclotide-cas-851199-59-2-pour-traiter-le-syndrome-du-colon-irritable-constipe-sci-c-et-la-constipation-idiopathique-chronique-cic\/","title":{"rendered":"Linaclotide CAS 851199-59-2 pour traiter le syndrome du c\u00f4lon irritable constip\u00e9 (SCI-C) et la constipation idiopathique chronique (CIC)"},"content":{"rendered":"

Linaclotide CAS 851199-59-2 pour traiter le syndrome du c\u00f4lon irritable constip\u00e9 (SCI-C) et la constipation idiopathique chronique (CIC)<\/strong><\/h2>\n

Nom du produit\u00a0: Linaclotide
\nSynonymes\u00a0: Linacllotide;Linaclotide;Linaelotide Acetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine, L-cyst\u00e9inyl-L-cyst\u00e9inyl-L-\u03b1-glutamyl-L-tyrosyl -L-cyst\u00e9inyl-L-cyst\u00e9inyl-L-asparaginyl-L-prolyl-L-alanyl-L-cyst\u00e9inyl-L-thr\u00e9onylglycyl-L-cyst\u00e9inyl-, cyclique (1\u21926),(2\u219210),(5\u2192 13)-tris(disulfure)
\nCAS\u00a0: 851199-59-2
\nMF\u00a0: C59H79N15O21S6
\nMW\u00a0: 1526.74
\nEINECS\u00a0:
\nCat\u00e9gories de produits\u00a0: Inhibiteurs
\nFichier Mol\u00a0: 851199-59 -2.mol<\/p>\n

Sp\u00e9cification du Linaclotide<\/strong> <\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Contenu des tests<\/td>\n Caract\u00e9ristiques<\/td>\n<\/tr>\n
Apparence<\/td>\n Poudre cristalline blanche ou presque blanche<\/td>\n<\/tr>\n
Identit\u00e9 par HPLC<\/td>\n La r\u00e9action est la m\u00eame avec la substance de r\u00e9f\u00e9rence<\/td>\n<\/tr>\n
Composition en acides amin\u00e9s<\/td>\n \u00b120 % de la th\u00e9orie<\/td>\n<\/tr>\n
Puret\u00e9 (HPLC)<\/td>\n 98,0%<\/td>\n<\/tr>\n
Substance associ\u00e9e (par HPLC)<\/td>\n Impuret\u00e9s totales(%)\u2264 2,0%
\nLa plus grande impuret\u00e9 unique(%)\u2264 1,0%<\/td>\n<\/tr>\n
Teneur en ac\u00e9tate (par HPLC)<\/td>\n \u226415%<\/td>\n<\/tr>\n
Teneur en eau (par HPLC)<\/td>\n 5,0%<\/td>\n<\/tr>\n
Endotoxines bact\u00e9riennes<\/td>\n \u22645UI\/mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Fonction et application du linaclotide<\/strong>
\n Le linaclotide est un agoniste peptidique de la guanylate cyclase 2C.<\/p>\n

Ce compos\u00e9 r\u00e9duit l'activation des neurones sensoriels du c\u00f4lon, r\u00e9duisant ainsi la douleur\u00a0; et active les motoneurones du c\u00f4lon, ce qui augmente la contraction des muscles lisses et favorise ainsi les selles.<\/p>\n

Il a \u00e9t\u00e9 approuv\u00e9 par la FDA en ao\u00fbt 2012 pour le traitement de la constipation idiopathique chronique et du syndrome du c\u00f4lon irritable \u00e0 pr\u00e9dominance de constipation (IBS-C ) chez l'adulte.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nom du produit\u00a0: Linaclotide
\nCAS\u00a0: 851199-59-2
\nMF\u00a0: C59H79N15O21S6
\nMW\u00a0: 1526.74
\nEINECS\u00a0:
\nCat\u00e9gories de produits\u00a0: Inhibiteurs
\nFichier Mol\u00a0: 851199-59-2. mole<\/p>\n","protected":false},"featured_media":2122,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[452],"product_tag":[],"class_list":{"0":"post-8945","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptide-du-systeme-gastro-intestinal","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product\/8945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/comments?post=8945"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media\/2122"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/media?parent=8945"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_brand?post=8945"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_cat?post=8945"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/fr\/wp-json\/wp\/v2\/product_tag?post=8945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}