{"id":7262,"date":"2021-12-16T07:20:05","date_gmt":"2021-12-16T12:20:05","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-untuk-anti-hiv\/"},"modified":"2021-12-16T07:20:05","modified_gmt":"2021-12-16T12:20:05","slug":"enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-untuk-anti-hiv","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/id\/product\/enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-untuk-anti-hiv\/","title":{"rendered":"Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 Untuk Anti HIV"},"content":{"rendered":"

Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 Untuk Anti HIV<\/strong><\/h2>\n

Nama Produk: Enfuvirtide
\nUrutan: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys< &>-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\nSinonim: Enfuvirtide; T-2;Enfuvirtide Acetate (T-20);ENFUVIRTIDE(T-20) 98+%;Enfurvitide(T-20);Pentafuside;Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH{2};Enfuvirtide;Aids059486
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-385-0
\nKategori Produk : protein;Peptide
\nMol File: 159519-65-0.mol<\/p>\n

Ini adalah inhibitor peptida sintetis dari fusi HIV, yang dapat mengikat glikoprotein amplop virus dan mencegah perubahan konformasi yang diperlukan untuk virus untuk menyatu dengan membran sel, sehingga menghambat replikasi peptida HIV-1.Enfevir berasal dari urutan asam amino alami dalam domain HR2 gp41. Dengan mensimulasikan aktivitas domain HR2 dan secara kompetitif mengikat ke domain HR1 gp41, peptida Enfevir mencegah interaksi antara HR1 dan HR2 dan perubahan konfigurasi Gp41, sehingga mencegah fusi virus dengan sel inang.<\/p>\n

Enfuvirtide adalah yang pertama dari kelas terapi HIV baru yang mengganggu masuknya HIV-1 dengan menghambat fusi virus dan membran sel. Ini mengikat heptad-repeat (HR1) pertama di subunit ghe gp41 dari glikoprotein amplop virus dan mencegah perubahan konformasi yang diperlukan untuk fusi dengan membran sel, sehingga mewakili mekanisme baru. Ini adalah penghambat kuat pengikatan ini dengan IC50 di laboratorium dan isolat primer (HIV-1 clades A\u2013G) mulai dari 4 hingga 280 nM (18-1260 ng\/mL), tetapi hampir tidak memiliki aktivitas melawan HIV-2. Karena mekanismenya yang unik, ia tidak menunjukkan resistensi silang terhadap NRTI, NNRTI dan PI. Ini disiapkan dengan sintesis kimia, menggunakan kombinasi langkah-langkah larutan dan fase padat. Tahap fase padat menggunakan proteksi fmoc dan resin 2-klorotritil klorida yang peka terhadap asam untuk menghasilkan peptida dengan panjang mulai dari sembilan hingga enam belas asam amino. <\/p>\n

Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 Sifat Kimia<\/strong>
\nsuhu penyimpanan. -20\u00b0C
\nbentuk bubuk
\nwarna putih sampai putih pudar<\/p>\n

Penggunaan Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0<\/strong>
\nDigunakan dalam kombinasi dengan obat reverse transcriptase untuk manusia infeksi virus imunodefisiensi (HIV).<\/p>\n","protected":false},"excerpt":{"rendered":"

Nama Produk: Enfuvirtide
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-385-0
\nBerkas Mol: 159519-65-0.mol<\/p>\n","protected":false},"featured_media":2125,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[514],"product_tag":[2500],"class_list":{"0":"post-7262","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptida-lainnya","7":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-id","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/id\/wp-json\/wp\/v2\/product\/7262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/id\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/id\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/id\/wp-json\/wp\/v2\/comments?post=7262"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/id\/wp-json\/wp\/v2\/media\/2125"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/id\/wp-json\/wp\/v2\/media?parent=7262"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/id\/wp-json\/wp\/v2\/product_brand?post=7262"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/id\/wp-json\/wp\/v2\/product_cat?post=7262"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/id\/wp-json\/wp\/v2\/product_tag?post=7262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}