{"id":8950,"date":"2021-12-17T03:39:58","date_gmt":"2021-12-17T08:39:58","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/linaclotide-cas-851199-59-2-per-trattare-la-sindrome-dellintestino-irritabile-stitico-ibs-c-e-la-costipazione-idiopatica-cronica-cic\/"},"modified":"2021-12-17T03:39:58","modified_gmt":"2021-12-17T08:39:58","slug":"linaclotide-cas-851199-59-2-per-trattare-la-sindrome-dellintestino-irritabile-stitico-ibs-c-e-la-costipazione-idiopatica-cronica-cic","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/it\/product\/linaclotide-cas-851199-59-2-per-trattare-la-sindrome-dellintestino-irritabile-stitico-ibs-c-e-la-costipazione-idiopatica-cronica-cic\/","title":{"rendered":"Linaclotide CAS 851199-59-2 Per trattare la sindrome dell&#39;intestino irritabile stitico (IBS-C) e la costipazione idiopatica cronica (CIC)"},"content":{"rendered":"<h2><strong>Linaclotide CAS 851199-59-2 Per trattare la sindrome dell&#39;intestino irritabile stitico (IBS-C) e la costipazione idiopatica cronica (CIC)<\/strong><\/h2>\n<p>Nome prodotto: Linaclotide<br \/>\nSinonimi: Linacllotide;Linaclotide;Linaelotide acetato;Linaelotide;CY-14;Liclotide;Argpessin;L-tirosina, L-cisteinil-L-cisteinil-L-\u03b1-glutamil-L-tirosile -L-cisteinil-L-cisteinil-L-asparaginil-L-prolil-L-alanil-L-cisteinil-L-treonilglicil-L-cisteinil-, ciclico (1\u21926),(2\u219210),(5\u2192 13)-tris(disolfuro)<br \/>\nCAS: 851199-59-2<br \/>\nMF: C59H79N15O21S6<br \/>\nMW: 1526.74<br \/>\nEINECS:<br \/>\nCategorie di prodotto: Inibitori<br \/>\nMol File: 851199-59 -2.mol<\/p>\n<p> <strong>Specifica del linaclotide<\/strong> <\/p>\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td> Contenuto del test<\/td>\n<td colspan=\"3\"> Specifiche<\/td>\n<\/tr>\n<tr>\n<td> Aspetto esteriore<\/td>\n<td colspan=\"3\"> Polvere cristallina bianca o quasi bianca<\/td>\n<\/tr>\n<tr>\n<td> Identit\u00e0 di HPLC<\/td>\n<td colspan=\"3\"> La reazione \u00e8 la stessa con la sostanza di riferimento<\/td>\n<\/tr>\n<tr>\n<td> Composizione degli aminoacidi<\/td>\n<td colspan=\"3\"> \u00b120% del teorico<\/td>\n<\/tr>\n<tr>\n<td> Purezza (HPLC)<\/td>\n<td colspan=\"3\"> \u2265 98,0%<\/td>\n<\/tr>\n<tr>\n<td> Sostanza correlata (da HPLC)<\/td>\n<td colspan=\"3\"> Impurit\u00e0 totali(%)\u2264 2,0%<br \/>\nImpurit\u00e0 singola maggiore (%)\u2264 1,0%<\/td>\n<\/tr>\n<tr>\n<td> Contenuto di acetato (mediante HPLC)<\/td>\n<td colspan=\"3\"> \u2264 15%<\/td>\n<\/tr>\n<tr>\n<td> Contenuto d&#39;acqua (mediante HPLC)<\/td>\n<td colspan=\"3\"> \u2264 5,0%<\/td>\n<\/tr>\n<tr>\n<td> Endotossine batteriche<\/td>\n<td colspan=\"3\"> 5UI\/mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p> <strong>Funzione e applicazione del linaclotide<\/strong><br \/>\nIl linaclotide \u00e8 un agonista peptidico della guanilato ciclasi 2C.<\/p>\n<p>Questo composto riduce l&#39;attivazione dei neuroni sensoriali del colon, riducendo il dolore; e attiva i motoneuroni del colon, che aumenta la contrazione della muscolatura liscia e quindi promuove i movimenti intestinali.<\/p>\n<p>\u00c8 stato approvato dalla FDA nell&#39;agosto 2012 per il trattamento della costipazione idiopatica cronica e della sindrome dell&#39;intestino irritabile con stipsi predominante (IBS-C ) negli adulti.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nome del prodotto: Linaclotide<br \/>\nCAS: 851199-59-2<br \/>\nMF: C59H79N15O21S6<br \/>\nMW: 1526.74<br \/>\nEINECS:<br \/>\nCategorie di prodotto: Inibitori<br \/>\nMol File: 851199-59-2. mole<\/p>\n","protected":false},"featured_media":2126,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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