{"id":8573,"date":"2021-12-17T01:47:30","date_gmt":"2021-12-17T06:47:30","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/nesiritide-bnp-32-menselijk-cas-124584-08-3-brain-natriuretic-peptide-voor-hartfalen\/"},"modified":"2021-12-17T01:47:30","modified_gmt":"2021-12-17T06:47:30","slug":"nesiritide-bnp-32-menselijk-cas-124584-08-3-brain-natriuretic-peptide-voor-hartfalen","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/nl\/product\/nesiritide-bnp-32-menselijk-cas-124584-08-3-brain-natriuretic-peptide-voor-hartfalen\/","title":{"rendered":"Nesiritide \/ BNP-32 (MENSELIJK) CAS 124584-08-3 Brain Natriuretic Peptide voor hartfalen"},"content":{"rendered":"

Nesiritide \/ BNP-32 (MENSELIJK) CAS 124584-08-3 Brain Natriuretic Peptide voor hartfalen<\/strong><\/h2>\n

Productnaam: Nesiritide \/ BNP-32 (HUMAN)
\n Synoniemen: Nesiritide, Brain Natriuretic Peptide-32 human,BNP-32, >98%;BNP-32 (human) hydrochloride;Nesiritide [USAN:INN] ;SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (DISULFIDEBRUG: 10-26);SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER -SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS;H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY -ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH;H-SER-PRO-LYS -MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL -LEU-ARG-ARG-HIS-OH (DISULFIDEBRUG: 10-26); BRAIN NATRIURETIC PEPTIDE (1-32), HUMAN
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nProductcategorie\u00ebn:
\nMol File: 124584-08-3.mol<\/p>\n

Nesiritide werd in de VS ge\u00efntroduceerd als een nieuwe intraveneuze behandeling voor pati\u00ebnten met acuut gedecompenseerd congestief hartfalen die kortademigheid hebben in rust of met minimale activiteit iteit. Nesiritide is de eerste menselijke recombinante vorm van het krachtige vaatverwijdende B-type natriuretisch peptide (ook bekend als natriuretisch peptide van de hersenen), een van nature voorkomend peptide van 32 aminozuren met een disulfide-gebonden ringstructuur van 17 aminozuren. Nesiritide bindt aan de Atype natriuretische peptidereceptor op het oppervlak van endotheliale en gladde spiercellen en stimuleert de productie van de tweede boodschapper cGMP die voornamelijk de relaxatie van vasculaire gladde spiercellen medieert. Het vergemakkelijkt ook de eliminatie van natrium en water door de nieren en vermindert de afscheiding van bepaalde hormonen, zoals adrenaline, angiotensine II, aldosteron en endotheline, die op lange termijn schadelijke effecten veroorzaken, waaronder vernauwing van bloedvaten en verhoging van de bloeddruk. In klinische onderzoeken met pati\u00ebnten met hartfalen verminderde nesidtide dosisafhankelijk de pulmonale capillaire wiggedruk, rechter atriumdruk en systemische vasculaire weerstand en verhoogde de hartindex zonder de hartslag te be\u00efnvloeden. De belangrijkste waargenomen bijwerking was dosisafhankelijke hypotensie. In een fase III vergelijkende studie bleek nesiritide superieur te zijn aan iv. nitroglycerine in zijn hemodynamische effecten, evenals gemakkelijker toe te dienen en beter te verdragen. Nesiritide wordt geklaard door proteolytische splitsing door het enzymneutrale endopeptidase NEP24.11 en door binding aan de C-type natriuretische peptidereceptor gevolgd door endocytose en intracellulaire lysosomale hydrolyse. Omdat het een korte halfwaardetijd heeft (18 min), wordt nesiritide toegediend als een bolusinfusie van 21 g\/kg, gevolgd door een continue onderhoudsinfusie van 0,011 \u03bcg\/kg\/min, gewoonlijk gedurende 24-48 uur.<\/p>\n

Nesiritide \/ BNP-32 (MENSELIJK) CAS 124584-08-3 Chemische eigenschappen<\/strong>
\nBNP-32 (MENSELIJK) Chemische eigenschappen
\ndichtheid 1,52\u00b10,1 g\/cm3 (voorspeld)
\nRTECS EE1534000
\nopslagtemp. \u221220\u00b0C
\nvorm poeder
\nOplosbaarheid in water Oplosbaar in water bij 1mg\/ml
\nCAS DataBase Reference 124584-08-3<\/p>\n

Functie en toepassing van Nesiritide \/ BNP-32 (HUMAN) CAS 124584-08-3<\/strong>
\nBehandeling van congestief hartfalen (renine-angiotensinesysteemantagonist).<\/p>\n","protected":false},"excerpt":{"rendered":"

Productnaam: Nesiritide \/ BNP-32 (HUMAN)
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nProductcategorie\u00ebn: < &>Mol-bestand: 124584-08-3.mol<\/p>\n","protected":false},"featured_media":2288,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[509],"product_tag":[1133],"class_list":{"0":"post-8573","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cardiovasculair-systeempeptide-carperitide-acetate-anp-1-28-human-cas-89213-87-6-nesiritide-bnp-32-human-cas-124584-08-3","7":"product_tag-nesiritide-bnp-32-human-cas-124584-08-3-brain-natriuretic-peptide-for-heart-failure-nl","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/nl\/wp-json\/wp\/v2\/product\/8573","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/nl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/nl\/wp-json\/wp\/v2\/comments?post=8573"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/nl\/wp-json\/wp\/v2\/media\/2288"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/nl\/wp-json\/wp\/v2\/media?parent=8573"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/nl\/wp-json\/wp\/v2\/product_brand?post=8573"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/nl\/wp-json\/wp\/v2\/product_cat?post=8573"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/nl\/wp-json\/wp\/v2\/product_tag?post=8573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}