{"id":7274,"date":"2021-12-16T07:20:09","date_gmt":"2021-12-16T12:20:09","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/enfuvirtida-acetato-de-enfuvirtida-cas-159519-65-0-para-anti-hiv\/"},"modified":"2021-12-16T07:20:09","modified_gmt":"2021-12-16T12:20:09","slug":"enfuvirtida-acetato-de-enfuvirtida-cas-159519-65-0-para-anti-hiv","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/pt-br\/product\/enfuvirtida-acetato-de-enfuvirtida-cas-159519-65-0-para-anti-hiv\/","title":{"rendered":"Enfuvirtida \/ acetato de enfuvirtida CAS 159519-65-0 para anti HIV"},"content":{"rendered":"

Enfuvirtida \/ acetato de enfuvirtida CAS 159519-65-0 para anti HIV<\/strong><\/h2>\n

Nome do produto: Enfuvirtida
\n Sequ\u00eancia: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys < &> – Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\n Sin\u00f4nimos: Enfuvirtida; T-2; Acetato de Enfuvirtida (T-20); ENFUVIRTIDE (T-20) 98 +%; Enfurvitida (T-20); Pentafusida; Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH {2}; Enfuvirtide; Aids059486
\n CAS: 159519-65-0
\n MF: C204H301N51O64
\n MW: 4491,92
\n EINECS: 641-385-0
\n Categorias de produtos : prote\u00ednas; Pept\u00eddeo
\n Arquivo Mol: 159519-65-0.mol <\/p>\n

\u00c9 um inibidor de pept\u00eddeo sint\u00e9tico da fus\u00e3o do HIV, que pode se ligar \u00e0 glicoprote\u00edna do envelope viral e prevenir as altera\u00e7\u00f5es conformacionais necess\u00e1rias para o v\u00edrus para se fundir com a membrana celular, inibindo assim a replica\u00e7\u00e3o do HIV-1. O pept\u00eddeo Enfevir \u00e9 derivado de uma sequ\u00eancia de amino\u00e1cidos de ocorr\u00eancia natural no dom\u00ednio HR2 de gp41. Simulando a atividade do dom\u00ednio HR2 e ligando-se competitivamente ao dom\u00ednio HR1 da gp41, o pept\u00eddeo Enfevir evita a intera\u00e7\u00e3o entre HR1 e HR2 e altera\u00e7\u00f5es na configura\u00e7\u00e3o do Gp41, evitando assim a fus\u00e3o do v\u00edrus com as c\u00e9lulas hospedeiras. <\/p>\n

Enfuvirtide \u00e9 o primeiro de uma nova classe de terap\u00eauticas do HIV que interfere com a entrada do HIV-1, inibindo a fus\u00e3o das membranas virais e celulares. Liga-se \u00e0 primeira repeti\u00e7\u00e3o do heptal (HR1) na subunidade ghe gp41 da glicoprote\u00edna do envelope viral e evita as altera\u00e7\u00f5es conformacionais necess\u00e1rias \u00e0 fus\u00e3o com as membranas celulares, representando assim um novo mecanismo. \u00c9 um inibidor potente desta liga\u00e7\u00e3o com um IC50 em isolados de laborat\u00f3rio e prim\u00e1rios (HIV-1 clades A \u2013 G) variando de 4 a 280 nM (18\u20131260 ng \/ mL), mas n\u00e3o tem virtualmente nenhuma atividade contra o HIV-2. Devido ao seu mecanismo \u00fanico, n\u00e3o apresenta resist\u00eancia cruzada a NRTI, NNRTI e IPs. \u00c9 preparado por s\u00edntese qu\u00edmica, usando uma combina\u00e7\u00e3o de etapas de solu\u00e7\u00e3o e fase s\u00f3lida. As etapas de fase s\u00f3lida utilizam prote\u00e7\u00e3o fmoc e a resina de cloreto de 2-clorotritila sens\u00edvel a \u00e1cido para produzir pept\u00eddeos com comprimentos que variam de nove a dezesseis amino\u00e1cidos. <\/p>\n

Enfuvirtide \/ Enfuvirtide Acetate CAS 159519-65-0 Propriedades qu\u00edmicas<\/strong>
\n temp. -20 \u00b0 C
\n forma de p\u00f3
\n cor branca a esbranqui\u00e7ada <\/p>\n

Usos de Enfuvirtida \/ Acetato de Enfuvirtida CAS 159519-65-0<\/strong>
\n \u00c9 usado em combina\u00e7\u00e3o com drogas de transcriptase reversa para humanos infec\u00e7\u00e3o pelo v\u00edrus da imunodefici\u00eancia (HIV).<\/p>\n","protected":false},"excerpt":{"rendered":"

Nome do produto: Enfuvirtide
\n CAS: 159519-65-0
\n MF: C204H301N51O64
\n MW: 4491.92
\n EINECS: 641-385-0
\n Arquivo Mol: 159519-65-0.mol<\/p>\n","protected":false},"featured_media":2129,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[533],"product_tag":[2508],"class_list":{"0":"post-7274","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-outros-peptideos","7":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-pt-br","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/product\/7274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/comments?post=7274"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/media\/2129"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/media?parent=7274"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/product_brand?post=7274"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/product_cat?post=7274"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/product_tag?post=7274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}