{"id":8961,"date":"2021-12-17T03:40:02","date_gmt":"2021-12-17T08:40:02","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/linaclotide-cas-851199-59-2-para-tratar-sindrome-do-intestino-irritavel-constipado-ibs-c-e-constipacao-idiopatica-cronica-cic\/"},"modified":"2021-12-17T03:40:02","modified_gmt":"2021-12-17T08:40:02","slug":"linaclotide-cas-851199-59-2-para-tratar-sindrome-do-intestino-irritavel-constipado-ibs-c-e-constipacao-idiopatica-cronica-cic","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/pt-br\/product\/linaclotide-cas-851199-59-2-para-tratar-sindrome-do-intestino-irritavel-constipado-ibs-c-e-constipacao-idiopatica-cronica-cic\/","title":{"rendered":"Linaclotide CAS 851199-59-2 para Tratar s\u00edndrome do intestino irrit\u00e1vel constipado (IBS-C) e constipa\u00e7\u00e3o idiop\u00e1tica cr\u00f4nica (CIC)"},"content":{"rendered":"

Linaclotide CAS 851199-59-2 para Tratar s\u00edndrome do intestino irrit\u00e1vel constipado (IBS-C) e constipa\u00e7\u00e3o idiop\u00e1tica cr\u00f4nica (CIC)<\/strong><\/h2>\n

Nome do produto: Linaclotida
\n Sin\u00f4nimos: Linaclotida; Linaclotida; Acetato de Linaelotida; Linaelotida; CY-14; Liclotida; Argpessina; L-tirosina, L-cisteinil-L-cisteinil-L-\u03b1-glutamil-L-tirosil -L-cisteinil-L-cisteinil-L-asparaginil-L-prolil-L-alanil-L-cisteinil-L-treonilglicil-L-cisteinil-, c\u00edclico (1 \u2192 6), (2 \u2192 10), (5 \u2192 13) -tris (dissulfeto)
\n CAS: 851199-59-2
\n MF: C59H79N15O21S6
\n MW: 1526,74
\n EINECS:
\n Categorias de produtos: Inibidores
\n Arquivo Mol: 851199-59 -2.mol <\/p>\n

Especifica\u00e7\u00e3o de Linaclotide<\/strong> <\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Conte\u00fado do teste<\/td>\n Especifica\u00e7\u00f5es<\/td>\n<\/tr>\n
Apar\u00eancia<\/td>\n P\u00f3 cristalino branco ou quase branco<\/td>\n<\/tr>\n
Identidade por HPLC<\/td>\n A rea\u00e7\u00e3o \u00e9 a mesma com a subst\u00e2ncia de refer\u00eancia<\/td>\n<\/tr>\n
Composi\u00e7\u00e3o de Amino\u00e1cidos<\/td>\n \u00b1 20% do te\u00f3rico<\/td>\n<\/tr>\n
Pureza (HPLC)<\/td>\n \u2265 98,0%<\/td>\n<\/tr>\n
Subst\u00e2ncia Relacionada (por HPLC)<\/td>\n Total de impurezas (%) \u2264 2,0%
\n Maior impureza \u00fanica (%) \u2264 1,0%<\/td>\n<\/tr>\n
Conte\u00fado de acetato (por HPLC)<\/td>\n \u226415%<\/td>\n<\/tr>\n
Conte\u00fado de \u00e1gua (por HPLC)<\/td>\n \u22645,0%<\/td>\n<\/tr>\n
Endotoxinas bacterianas<\/td>\n \u22645IU \/ mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Fun\u00e7\u00e3o e aplica\u00e7\u00e3o de Linaclotide<\/strong>
\n Linaclotide \u00e9 um agonista pept\u00eddico da guanilato ciclase 2C. <\/p>\n

Este composto reduz a ativa\u00e7\u00e3o de neur\u00f4nios sensoriais do c\u00f3lon, reduzindo a dor; e ativa os neur\u00f4nios motores do c\u00f3lon, o que aumenta a contra\u00e7\u00e3o do m\u00fasculo liso e, portanto, promove os movimentos intestinais. <\/p>\n

Foi aprovado pelo FDA em agosto de 2012 para o tratamento de constipa\u00e7\u00e3o idiop\u00e1tica cr\u00f4nica e s\u00edndrome do intestino irrit\u00e1vel com predomin\u00e2ncia de constipa\u00e7\u00e3o (IBS-C ) em adultos.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nome do produto: Linaclotide
\n CAS: 851199-59-2
\n MF: C59H79N15O21S6
\n MW: 1526,74
\n EINECS:
\n Categorias de produto: Inibidores
\n Arquivo Mol: 851199-59-2. mol<\/p>\n","protected":false},"featured_media":2129,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[456],"product_tag":[],"class_list":{"0":"post-8961","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptideo-do-sistema-gastrointestinal","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/product\/8961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/comments?post=8961"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/media\/2129"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/media?parent=8961"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/product_brand?post=8961"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/product_cat?post=8961"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/pt-br\/wp-json\/wp\/v2\/product_tag?post=8961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}