{"id":7259,"date":"2021-12-16T07:18:57","date_gmt":"2021-12-16T12:18:57","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/enfuvirtide-enfuvirtide-acetat-cas-159519-65-0-pentru-anti-hiv\/"},"modified":"2021-12-16T07:18:57","modified_gmt":"2021-12-16T12:18:57","slug":"enfuvirtide-enfuvirtide-acetat-cas-159519-65-0-pentru-anti-hiv","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/ro\/product\/enfuvirtide-enfuvirtide-acetat-cas-159519-65-0-pentru-anti-hiv\/","title":{"rendered":"Enfuvirtide\/ Enfuvirtide Acetat CAS 159519-65-0 pentru anti HIV"},"content":{"rendered":"

Enfuvirtide\/ Enfuvirtide Acetat CAS 159519-65-0 pentru anti HIV<\/strong><\/h2>\n

Nume produs: Enfuvirtide
\nSecven\u021b\u0103: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys< &>-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\n Sinonime: Enfuvirtide; T-2; Acetat de enfuvirtid\u0103 (T-20); ENFUVIRTIDE (T-20) 98+%; Enfurvitid\u0103 (T-20); Pentafuzid\u0103; Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH{2};Enfuvirtide;Aids059486
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-385-0
\nCategorii de produse
\n : proteins;Peptide
\nMol File: 159519-65-0.mol<\/p>\n

Este un inhibitor peptidic sintetic al fuziunii HIV, care se poate lega de glicoproteina \u00eenveli\u0219ului viral \u0219i poate preveni modific\u0103rile conforma\u021bionale necesare virusului pentru a fuziona cu membrana celular\u0103, inhib\u00e2nd astfel replicarea HIV-1. Peptida Enfevir este derivat\u0103 dintr-o secven\u021b\u0103 natural\u0103 de aminoacizi \u00een domeniul HR2 al gp41. Prin simularea activit\u0103\u021bii domeniului HR2 \u0219i legarea competitiv\u0103 de domeniul HR1 al gp41, peptida Enfevir previne interac\u021biunea dintre HR1 \u0219i HR2 \u0219i modific\u0103ri \u00een configura\u021bia Gp41, prevenind astfel fuziunea virusului cu celulele gazd\u0103.<\/p>\n

Enfuvirtida este primul dintr-o nou\u0103 clas\u0103 de terapii HIV care interfereaz\u0103 cu intrarea HIV-1 prin inhibarea fuziunii membranelor virale \u0219i celulare. Se leag\u0103 de prima heptad-repeat (HR1) din subunitatea ghe gp41 a glicoproteinei \u00eenveli\u0219ului viral \u0219i previne modific\u0103rile conforma\u021bionale necesare fuziunii cu membranele celulare, reprezent\u00e2nd astfel un nou mecanism. Este un inhibitor puternic al acestei leg\u0103turi cu un IC50 \u00een laborator \u0219i izolate primare (cladele HIV-1 A\u2013G) variind de la 4 la 280 nM (18\u20131260 ng\/mL), dar practic nu are activitate \u00eempotriva HIV-2. Datorit\u0103 mecanismului s\u0103u unic, nu prezint\u0103 rezisten\u021b\u0103 \u00eencruci\u0219at\u0103 la NRTI, NNRTI \u0219i PI. Se prepar\u0103 prin sintez\u0103 chimic\u0103, folosind o combina\u021bie de etape \u00een solu\u021bie \u0219i faz\u0103 solid\u0103. Etapele \u00een faz\u0103 solid\u0103 utilizeaz\u0103 protec\u021bia fmoc \u0219i r\u0103\u0219ina de clorur\u0103 de 2-clorotritil sensibil\u0103 la acid pentru a produce peptide cu lungimi cuprinse \u00eentre nou\u0103 \u0219i \u0219aisprezece aminoacizi. <\/p>\n

Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 Propriet\u0103\u021bi chimice<\/strong>
\ntemp. -20\u00b0C
\nform\u0103 pulbere
\nculoare alb p\u00e2n\u0103 la aproape alb<\/p>\n

Utiliz\u0103ri de Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0<\/strong>
\nSe utilizeaz\u0103 \u00een combina\u021bie cu medicamente cu revers transcriptaz\u0103 pentru om infec\u021bie cu virusul imunodeficien\u021bei (HIV).<\/p>\n","protected":false},"excerpt":{"rendered":"

Nume produs: Enfuvirtide
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491,92
\nEINECS: 641-385-0
\nMol File: 159519-65-0.mol<\/p>\n","protected":false},"featured_media":2130,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[517],"product_tag":[2497],"class_list":{"0":"post-7259","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alte-peptide","7":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-ro","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product\/7259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/comments?post=7259"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media\/2130"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media?parent=7259"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_brand?post=7259"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_cat?post=7259"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_tag?post=7259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}