{"id":8105,"date":"2021-12-16T12:18:41","date_gmt":"2021-12-16T17:18:41","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/acetat-de-ziconotida-cas-107452-89-1-tratament-pentru-nevralgia-postherpetica-si-durerea-canceroasa\/"},"modified":"2021-12-16T12:18:41","modified_gmt":"2021-12-16T17:18:41","slug":"acetat-de-ziconotida-cas-107452-89-1-tratament-pentru-nevralgia-postherpetica-si-durerea-canceroasa","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/ro\/product\/acetat-de-ziconotida-cas-107452-89-1-tratament-pentru-nevralgia-postherpetica-si-durerea-canceroasa\/","title":{"rendered":"Acetat de ziconotid\u0103 CAS 107452-89-1 Tratament pentru nevralgia postherpetic\u0103 \u0219i durerea canceroas\u0103"},"content":{"rendered":"

Acetat de ziconotid\u0103 CAS 107452-89-1 Tratament pentru nevralgia postherpetic\u0103 \u0219i durerea canceroas\u0103<\/strong><\/h2>\n

Nume produs: acetat de ziconotid\u0103
\nSinome: OMEGA-CONOTOXIN MVIIA;OMEGA-CGTX MVII A;ZICONOTIDE ACETAT;snx111;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG -LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS -SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (PUNTE DISULFUR\u0102: 1-16, 8-20 \u0218I 15 -25);CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY- LYS-CYS-NH2;CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (PUNTE DISULFUR\u0102: 1-16,8-20 \u0218I 15-25)
\nCAS: 107452-89-1
\nMF: C102H172N36O32S7.
\n32S7
\n >EINECS:
\nCategorii de produse: Peptide
\nMol Fi\u0219ier: 107452-89-1.mol<\/p>\n

Ziconotide (Prialt) este un compus toxin\u0103 peptidic\u0103 cu 25 de aminoacizi \u0219i trei disulfuri legat\u0103 de peptide derivate din sud Melc marin din Pacific Conusmagus. Este primul agent neuroterapeutic nou – blocantul canalelor de calciu de tip N (NCCB). Ac\u021bioneaz\u0103 selectiv asupra canalelor de calciu Chemicalbook electrosensibile de tip N din ramurile terminale dendritice \u0219i axonale, inhib\u00e2nd astfel aferentele stimulului ini\u021bial ale leziunii. Este indicat pacientilor cu dureri cronice severe care necesita tratament intratecal si care sunt intoleranti sau au o eficacitate slaba la alte tratamente analgezice (de exemplu, aplicarea de analgezice sistemice sau morfina intratecala). Ziconotida intratecal\u0103 poate fi utilizat\u0103 pentru a trata nevralgia postherpetic\u0103, durerea la nivelul membrelor fantom\u0103, durerea neuropatic\u0103 legat\u0103 de HIV, durerea canceroas\u0103 refractar\u0103 \u0219i durerea post-chirurgical\u0103.<\/p>\n

Acetat de ziconotid\u0103 CAS 107452-89-1 Propriet\u0103\u021bi chimice<\/strong>
\ndensitate 1,60 \u00b1 0,1 g\/cm3 (prev\u0103zut)
\ntemp. -20\u00b0C
\nInChIKey BPKIMPVREBSLAJ-QTBYCLKRSA-N<\/p>\n

Utiliz\u0103ri ale acetatului de ziconotid\u0103 CAS 107452-89-1<\/strong>
\nLigand pentru studiile de legare a canalelor de calciu sensibile la tensiune.<\/p>\n

Ziconotide ( SNX-111; Prialt), numit\u0103 \u0219i ziconotid\u0103 intratecal\u0103 (ITZ) datorit\u0103 c\u0103ii de administrare, este un agent analgezic atipic pentru ameliorarea durerii severe \u0219i cronice. Derivat din Conus magus, un melc con, este forma sintetic\u0103 a unei peptide \u03c9-conotoxin\u0103.[1] Este de 1.000 de ori mai puternic dec\u00e2t morfina.<\/p>\n

Acest produs este potrivit pentru pacien\u021bii cu dureri cronice severe care necesit\u0103 tratament intratecal \u0219i care sunt intoleran\u021bi sau au o eficacitate slab\u0103 la alte tratamente analgezice (cum ar fi aplicarea de analgezice sistemice sau injec\u021bie intratecal\u0103 de morfin\u0103 etc.).<\/p>\n

Func\u021bia \u0219i aplicarea acetatului de ziconotid\u0103 CAS 107452-89-1<\/strong>
\n1. Eficacitate analgezic\u0103 Ziconotida este potrivit\u0103 pentru pacien\u021bii cu dureri cronice care nu pot tolera sau nu r\u0103spund la alte tratamente, inclusiv medica\u021bie sistemic\u0103, tratamentul adjuvant al inject\u0103rii intratecale de morfin\u0103. Injectarea intratecal\u0103 de ziconotid\u0103 are o eficacitate analgezic\u0103 semnificativ\u0103 clinic \u0219i statistic la pacien\u021bii cu cancer sau SIDA.<\/p>\n

2. Protec\u021bia m\u0103duvei spin\u0103rii Ischemia m\u0103duvei spin\u0103rii pe termen scurt C\u00e2nd neuronii m\u0103duvei spin\u0103rii sunt deteriora\u021bi, exist\u0103 activarea c\u0103ii calciului electrosensibile de tip N. Ziconotida poate oferi neuroprotec\u021bie \u0219i analgezie \u00een timpul interven\u021biei chirurgicale aortice.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nume produs: Acetat de ziconotid\u0103
\nCAS: 107452-89-1
\nMF: C102H172N36O32S7
\nMW: 2639,13
\nMol Fi\u0219ier: 107452-89-1.mol<\/p>\n","protected":false},"featured_media":2214,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[],"product_tag":[1585],"class_list":{"0":"post-8105","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_tag-ziconotide-acetate-cas-107452-89-1-treat-for-postherpetic-neuralgia-and-cancer-pain-ro","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product\/8105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/comments?post=8105"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media\/2214"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media?parent=8105"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_brand?post=8105"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_cat?post=8105"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_tag?post=8105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}