{"id":8297,"date":"2021-12-16T13:20:58","date_gmt":"2021-12-16T18:20:58","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/acetat-de-somatostatina-peptidica-de-inalta-calitate-15-28-somatostatin-28-cas-38916-34-6\/"},"modified":"2021-12-16T13:20:58","modified_gmt":"2021-12-16T18:20:58","slug":"acetat-de-somatostatina-peptidica-de-inalta-calitate-15-28-somatostatin-28-cas-38916-34-6","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/ro\/product\/acetat-de-somatostatina-peptidica-de-inalta-calitate-15-28-somatostatin-28-cas-38916-34-6\/","title":{"rendered":"Acetat de somatostatina peptidic\u0103 de \u00eenalt\u0103 calitate\/ 15-28-Somatostatin-28 CAS 38916-34-6"},"content":{"rendered":"

Acetat de somatostatina peptidic\u0103 de \u00eenalt\u0103 calitate\/ 15-28-Somatostatin-28 CAS 38916-34-6<\/strong><\/h2>\n

Numele produsului: Acetat de somatostatina\/ 15-28-Somatostatin-28
\nSinome: Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH ;Factor de inhibare a eliber\u0103rii de SoMatotropin, SRIF, SRIF-14;Somatostatina ciclic\u0103;Acetat de SoMatostatin;FACTOR INHIBIT\u0102 A ELIBER\u0102RII HORMONULUI DE CRE\u0218TERE (OM, OVIN, PORCIN, \u0218OOL, \u0218ORICE); SOARECE) 2ACOH 6H2O;H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH;H-ALA-GLY-CYS-LYS-ASN-PHE -PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (CUPLAT LA BSA)
\nCAS: 38916-34-6
\nMF: C76H104N18O19S2
\nMW: 1637,88
\nEINECS: 254-186-5
\nCategorii de produse: Deriva\u021bi de aminoacizi;Aminoacizi \u0219i deriva\u021bi;Peptide;Aminoacizi 13C, 2H, 15N;Intermediari \u0219i produse chimice fine;Farmaceutice;peptide pharm
\nFi\u0219ier Mol: 389616 .mol<\/p>\n

Somatostatina este o 14-peptid\u0103 ciclic\u0103 care a fost izolat\u0103 pentru prima dat\u0103 de Guillemin \u00een 1973 \u0219i este probabil cel mai am\u0103nun\u021bit \u0219i cel mai important dintre factorii inhibitori produ\u0219i de hipota. lamus. Activitatea principal\u0103 a somatostatinei, care este de origine hipotalamic\u0103, este inhibarea eliber\u0103rii hormonului de cre\u0219tere (GH) din hipofiza anterioar\u0103. Prea mult\u0103 GH, ca \u00een tumorile hipofizare, provoac\u0103 acromegalie, o form\u0103 de giantism. Pe de alt\u0103 parte, prea pu\u021bin\u0103 GH duce la nanism. Somatostatina a fost g\u0103sit\u0103 \u0219i \u00een pancreas \u0219i tractul gastro-intestinal, unde inhib\u0103 at\u00e2t secre\u021bia de insulin\u0103, c\u00e2t \u0219i de glucagon din pancreas, precum \u0219i secre\u021bia unei variet\u0103\u021bi de peptide intestinale (de exemplu, gastrin\u0103, secretin\u0103, pepsin\u0103 \u0219i renina). Timpul scurt de \u00eenjum\u0103t\u0103\u021bire al somatostatinei, care este mai mic de 3 minute, a \u00eempiedicat utilizarea sa ca agent terapeutic. Mul\u021bi deriva\u021bi ai somatostatinei au fost preg\u0103ti\u021bi pentru a-\u0219i cre\u0219te durata de ac\u021biune \u0219i\/sau pentru a-\u0219i spori selectivitatea de ac\u021biune. Punctul culminant al acestor studii de structur\u0103-activitate a fost dezvoltarea acetatului de octreotid\u0103.<\/p>\n

Pe l\u00e2ng\u0103 hipotalamus, alte p\u0103r\u021bi precum cortexul cerebral, striatul, amigdala, hipocampul \u0219i m\u0103duva spin\u0103rii, nervul simpatic, gastrointestinal, insula, rinichii, glandele tiroide \u0219i paratiroide sunt larg distribuite \u00een somatostatina. \u00cen creier \u0219i tractul gastrointestinal, au fost purifica\u021bi 28 de aminoacizi ai GHRIH28, care este o extensie exterioar\u0103 a cap\u0103tului N-terminal al GHRIH14. Efectul somatostatinei in vitro este complicat \u0219i poate ac\u021biona ca transmi\u021b\u0103tor sau poate modula \u00een sistemul nervos; somatostatina are un anumit efect inhibitor asupra motilit\u0103\u021bii gastrointestinale \u0219i secre\u021biei hormonilor din tractul digestiv; de asemenea inhiba insulina si pancreasul Glucagonul, renina, hormonul paratiroidian si secretia de calcitonina<\/strong> . Propriet\u0103\u021bi chimice
\nPunctul de fierbere 1970,9\u00b165,0 \u00b0C(Predic\u021bie)
\ndensitate 1,43\u00b10,1 g\/cm3(Previzual)
\ntemp. \u221220\u00b0C
\nsolubilitate H2O: 1 mg\/mL
\npka 2,94\u00b10,70(Prevista)
\nform\u0103 pulbere
\nSolubilitate \u00een ap\u0103 Solubil \u00een ap\u0103(25,00\u00b0C 1,00 g\/L) , Metanol.
\nMerck 13,8788
\nBRN 6436064
\nInChIKey NHXLMOGPVYXJNR-ATOGVRKGSA-N<\/p>\n

Func\u021bia \u0219i aplicarea acetatului de somatostatina\/15-28-Somatostatin-28 CAS<\/strong> <& >
\n1 Poate inhiba secre\u021bia de hormon de cre\u0219tere, hormon de stimulare a tiroidei, insulin\u0103, glucagon.<\/p>\n

2 Poate inhiba secre\u021bia de acid gastric stimulat\u0103 de masa de testare \u0219i gastrin\u0103 cu 5 peptide \u0219i poate inhiba eliberarea de pepsin\u0103 \u0219i gastrin\u0103.<\/p>\n

3 Poate reduce semnificativ fluxul sanguin visceral, reduce presiunea portal\u0103, reduce fluxul sanguin \u0219i presiunea circula\u021biei colaterale, reduce fluxul sanguin la ficat.<\/p>\n

4 Reduce secre\u021bia a pancreasului \u0219i secre\u021bia intestinului sub\u021bire \u0219i a vezicii biliare, reduc activitatea enzimatic\u0103 \u0219i au un efect protector asupra celulelor pancreatice.<\/p>\n

5 Poate afecta absorb\u021bia \u0219i func\u021bia nutri\u021bional\u0103 a tractului gastrointestinal.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nume produs: Acetat de somatostatina\/ 15-28-Somatostatin-28
\nCAS: 38916-34-6
\nMF: C76H104N18O19S2
\nMW: 1637,88
\nEINECS: 254-186-5
\nMol File : 38916-34-6.mol<\/p>\n","protected":false},"featured_media":2130,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[517],"product_tag":[],"class_list":{"0":"post-8297","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alte-peptide","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product\/8297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/comments?post=8297"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media\/2130"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media?parent=8297"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_brand?post=8297"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_cat?post=8297"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_tag?post=8297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}