{"id":8379,"date":"2021-12-16T13:26:54","date_gmt":"2021-12-16T18:26:54","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/acetat-de-pramlintida-cas-196078-30-5-este-un-agent-antidiabetic-care-poate-fi-folosit-si-in-cercetarea-cancerului-intestinal\/"},"modified":"2021-12-16T13:26:54","modified_gmt":"2021-12-16T18:26:54","slug":"acetat-de-pramlintida-cas-196078-30-5-este-un-agent-antidiabetic-care-poate-fi-folosit-si-in-cercetarea-cancerului-intestinal","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/ro\/product\/acetat-de-pramlintida-cas-196078-30-5-este-un-agent-antidiabetic-care-poate-fi-folosit-si-in-cercetarea-cancerului-intestinal\/","title":{"rendered":"Acetat de pramlintid\u0103 CAS 196078-30-5 este un agent antidiabetic care poate fi folosit \u0219i \u00een cercetarea cancerului intestinal"},"content":{"rendered":"

Acetat de pramlintid\u0103 CAS 196078-30-5 este un agent antidiabetic care poate fi folosit \u0219i \u00een cercetarea cancerului intestinal<\/strong><\/h2>\n

Denumire produs: acetat de pramlintide
\nSinome: AMYLIN (UMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETAT (SARE), HIDRAT;acetat de pramlintid\u0103;acetat de pramlintid\u0103 hidrat ;25-L-Prolina-28-L-prolina-29-L-prolina-aMylin (uman) Acetat Hidrat;AC-137 Acetat Hidrat, SyMlin Acetat Hidrat;Tripo-aMylin Acetat Hidrat;Pramlintid\u0103 Acetat, Acetat de amilin\u0103;Pramlintid\u0103 fandachem
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027,46
\nEINECS:
\nCategorii de produse: aminoacizi \u0219i deriva\u021bi;baze \u0219i reactivi \u00eenrudi\u021bi;intermediari;analogi de medicamente; & Fine Chemicals;Nucleotides;Peptide;Pharmaceuticals
\nMol File: 196078-30-5.mol<\/p>\n

Acetatul de pramlintid\u0103 este un analog al amilinei umane injectabil care a fost lansat at\u00e2t pentru tratamentul de tip 1, c\u00e2t \u0219i de tip 2 diabet zaharat, \u00een combina\u021bie cu insulina. De\u0219i este, de asemenea, o peptid\u0103 cu 37 de aminoacizi, difer\u0103 de predecesorul s\u0103u p\u0103rinte prin \u00eenlocuirea Ala-25, Ser-28 \u0219i Ser-29 cu proline. Aceste modific\u0103ri nu numai c\u0103 \u00eembun\u0103t\u0103\u021besc solubilitatea peptidei, dar elimin\u0103 \u0219i agregarea observat\u0103 cu amilin\u0103, rezult\u00e2nd un analog sintetic stabil cu re\u021binerea activit\u0103\u021bii biologice, care este adecvat pentru uz farmaceutic. Ca o indica\u021bie a poten\u021bei, acetatul de pramlintid\u0103 inhib\u0103 legarea amilinei de \u0219obolan iodat radioactiv la membranele nucleului accumbens de \u0219obolan cu o valoare Ki de 23 pM. Mecanismul s\u0103u de ac\u021biune imit\u0103 amilina; ca neurohormon care este cosecretat cu insulina din celulele \u03b2 pancreatice ca r\u0103spuns la mese, este implicat \u00een homeostazia glucozei. Ambele peptide scad nivelurile postprandiale de glucoz\u0103 prin inhibarea glucagonului \u0219i prin restr\u00e2ngerea ratei de golire gastric\u0103 mediat\u0103 de vag, \u00eencetinind astfel absorb\u021bia intestinal\u0103 a carbohidra\u021bilor. \u00cen plus, amilina sau acetatul de pramlintid\u0103 are avantajul suplimentar de a induce sa\u021bietatea postprandial\u0103, ceea ce duce la pierderea \u00een greutate la pacien\u021bii cu diabet zaharat de tip 2. Deoarece acetatul de pramlintid\u0103 \u00eencetine\u0219te golirea gastric\u0103, este contraindicat la pacien\u021bii cu gastroparez\u0103 \u0219i la pacien\u021bii care iau medicamente care modific\u0103 motilitatea gastrointestinal\u0103 (agen\u021bi anticolinergici, cum ar fi atropina) sau \u00eencetinesc absorb\u021bia intestinal\u0103 a nutrien\u021bilor (cum ar fi inhibitorii de \u03b1-glucozidaz\u0103). Acetatul de pramlintid\u0103 este, de asemenea, contraindicat la pacien\u021bii cu tendin\u021be hipoglicemiante; din cauza administr\u0103rii concomitente cu insulin\u0103, hipoglicemia sever\u0103 indus\u0103 de insulin\u0103 reprezint\u0103 un risc. Cele mai frecvent raportate evenimente adverse includ grea\u021b\u0103, v\u0103rs\u0103turi, anorexie, dureri de cap, dureri abdominale, oboseal\u0103, ame\u021beli, tuse \u0219i faringit\u0103.<\/p>\n

Func\u021bia \u0219i aplicarea CAS 196078-30-5<\/strong> <\/p>\n

Pramlintide acetatul este un analog sintetic al polipeptidei amiloid pancreatice (Amylin, amilopectin) \u0219i este al doilea medicament aprobat pentru tratamentul diabetului de tip 1 dup\u0103 insulin\u0103. \u00cen practica clinic\u0103, pramlintida este utilizat\u0103 ca medicament adjuvant pentru tratamentul diabetului zaharat de tip 1 \u0219i tip 2, \u00een principal pentru pacien\u021bii cu diabet zaharat care nu au reu\u0219it s\u0103 ob\u021bin\u0103 rezultatele a\u0219teptate doar cu insulin\u0103 \u0219i cu combina\u021bia de insulin\u0103 \u0219i sulfoniluree \u0219i metformin\u0103. Pramlintida poate fi utilizat\u0103 \u00een combina\u021bie cu insulina, dar nu poate \u00eenlocui insulina.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nume produs: acetat de pramlintid\u0103
\nCAS: 196078-30-5
\nMF: C173H273N51O56S2
\nMW: 4027,46
\nMol Fi\u0219ier: 196078-30-5.mol<\/p>\n","protected":false},"featured_media":2214,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[348],"product_tag":[1292],"class_list":{"0":"post-8379","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptida-de-diabet","7":"product_tag-pramlintide-acetate-cas-196078-30-5-is-an-antidiabetic-agent-that-can-also-be-used-in-bowel-cancer-research-ro","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product\/8379","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/comments?post=8379"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media\/2214"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media?parent=8379"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_brand?post=8379"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_cat?post=8379"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_tag?post=8379"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}