{"id":8425,"date":"2021-12-16T13:29:07","date_gmt":"2021-12-16T18:29:07","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/vanzare-fierbinte-peptide-farmaceutice-pasireotide-cas-396091-73-9\/"},"modified":"2021-12-16T13:29:07","modified_gmt":"2021-12-16T18:29:07","slug":"vanzare-fierbinte-peptide-farmaceutice-pasireotide-cas-396091-73-9","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/ro\/product\/vanzare-fierbinte-peptide-farmaceutice-pasireotide-cas-396091-73-9\/","title":{"rendered":"V\u00e2nzare fierbinte Peptide farmaceutice Pasireotide CAS 396091-73-9"},"content":{"rendered":"

V\u00e2nzare fierbinte Peptide farmaceutice Pasireotide CAS 396091-73-9<\/strong><\/h2>\n

Nume produs: PASIREOTIDE
\nSinome: PASIREOTIDE;Ciclo[(2S)-2-fenilglicil-D-triptofil-L-lisil-O-(fenilmetil)-L-tirosil-L-fenilalanil-(4R)- 4-[[[(2-aminoetil)amino]carbonil]oxi]-L-prolil];SOM 230;SOM 320;[(3S,6S,9S,12R,15S,18S,20R)-9-(4- aminobutil)-3-benzil-12-(1 H-indol-3-ilmetil)-2,5,8,11,14,17-hexaoxo-15-fenil-6-[(4-fenilmetoxifenil)metil]-1, N-(2-aminoetil)carbamat de 4,7,10,13,16-hexazabiciclo[16.3.0]henicosan-20-il];SOM 230;SOM 320;CICLO((4R)-4-(2-AMINOETILCARBAMILOXY) -L-PROLIL-L-FENILGLICIL-D-TRIPTOFIL-L-LISIL-4-O-BENZIL-L-TIROSIL-L-FENILLANIL-)
\nCAS: 396091-73-9
\nMF: C58H66N10O9<& >MW: 1047.23
\nEINECS:
\nCategorii de produse:
\nFi\u0219ier Mol: 396091-73-9.mol<\/p>\n

\u00cen aprilie 2012, Comisia European\u0103 a aprobat pasireotida pentru tratamentul bolii Cushing ( CD) la pacien\u021bii adul\u021bi care nu au r\u0103spuns la interven\u021bia chirurgical\u0103 sau pentru care interven\u021bia chirurgical\u0103 nu este o op\u021biune. Pasireotida a fost aprobat\u0103 pentru aceea\u0219i indica\u021bie de FDA din SUA \u00een decembrie 2012. Pasireotida (de asemenea k acum SOM230) este o ciclohexapeptid\u0103 care ac\u021bioneaz\u0103 ca un analog al somatostatinei pentru a inhiba eliberarea de ACTH. Somatostatinele sunt peptide ciclice cu 14 \u0219i 28 de aminoacizi care joac\u0103 un rol important \u00een reglarea eliber\u0103rii endocrine \u0219i exocrine \u00een multe \u021besuturi printr-un mecanism inhibitor. Exist\u0103 cinci subtipuri cunoscute de receptori de somatostatina (SSTR). Somatostatinele naturale se leag\u0103 cu afinitate mare de toate cele cinci subtipuri, cu toate acestea, utilizarea lor terapeutic\u0103 este limitat\u0103 de degradarea rapid\u0103 \u00een plasm\u0103. Pasireotida a ap\u0103rut din eforturile de identificare a unui somatostatinmimetic cu efecte inhibitoare de lung\u0103 durat\u0103. Pornind de la o peptid\u0103 de somatostatin cu 14 aminoacizi, o scanare sistematic\u0103 cu alanin\u0103 a eviden\u021biat reziduuri care erau esen\u021biale pentru legarea subtipului de receptor, inclusiv regiunile cheie b-turn \u0219i reziduurile adiacente. Plasarea elementelor structurale cheie ca aminoacizi nenaturali \u00eentr-o coloan\u0103 vertebral\u0103 a ciclohexapeptidei a dat pasireotid\u0103.<\/p>\n

PASIREOTIDE CAS 396091-73-9<\/strong>
\nPunctul de fierbere 1351,4\u00b165,0 \u00b0C(Previzat)
\ndensitate 1,36\u00b10,1 g \/cm3(Predicted)
\npka 11,86\u00b10,46(Predicted)
\nCAS DataBase Reference 396091-73-9<\/p>\n

Func\u021bia \u0219i aplicarea PASIREOTIDE CAS 396091-73-9<\/strong>
\nCa inhibitor de cre\u0219tere analog care se leag\u0103 de receptori multipli, pasireotida s-a dovedit a fi mai eficient\u0103 dec\u00e2t analogii inhibitori de cre\u0219tere, cum ar fi octreotida \u0219i lanreotida, \u00een tratamentul acromegaliei, tumorilor carcinoide \u0219i bolii Cushing, at\u00e2t \u00een studiile preclinice, cum ar fi testele celulare \u0219i studiile pe animale, c\u00e2t \u0219i \u00een studii clinice. Rezultatele studiului de faz\u0103 II \u0219i ale unui studiu de faz\u0103 III asupra pasireotidei au confirmat c\u0103 pasireotida este un tratament nou pentru acromegalia nou\u0103 sau persistent\u0103 \u0219i tumorile carcinoide metastatice \u0219i poate fi prima alegere de tratament medicamentos pentru boala Cushing.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nume produs: PASIREOTIDE
\nMF: C58H66N10O9
\nMW: 1047,23
\nEINECS:
\nMol File: 396091-73-9.mol<\/p>\n","protected":false},"featured_media":2214,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[517],"product_tag":[1251],"class_list":{"0":"post-8425","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-alte-peptide","7":"product_tag-hot-sale-pharmaceutical-peptidespasireotide-cas-396091-73-9-ro","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product\/8425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/comments?post=8425"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media\/2214"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media?parent=8425"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_brand?post=8425"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_cat?post=8425"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_tag?post=8425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}