{"id":8577,"date":"2021-12-17T01:47:32","date_gmt":"2021-12-17T06:47:32","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/nesiritide-bnp-32-uman-cas-124584-08-3-peptida-natriuretica-cerebrala-pentru-insuficienta-cardiaca\/"},"modified":"2021-12-17T01:47:32","modified_gmt":"2021-12-17T06:47:32","slug":"nesiritide-bnp-32-uman-cas-124584-08-3-peptida-natriuretica-cerebrala-pentru-insuficienta-cardiaca","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/ro\/product\/nesiritide-bnp-32-uman-cas-124584-08-3-peptida-natriuretica-cerebrala-pentru-insuficienta-cardiaca\/","title":{"rendered":"Nesiritide \/ BNP-32 (UMAN) CAS 124584-08-3 Peptida natriuretic\u0103 cerebral\u0103 pentru insuficien\u021b\u0103 cardiac\u0103"},"content":{"rendered":"

Nesiritide \/ BNP-32 (UMAN) CAS 124584-08-3 Peptida natriuretic\u0103 cerebral\u0103 pentru insuficien\u021b\u0103 cardiac\u0103<\/strong><\/h2>\n

Numele produsului: Nesiritide \/ BNP-32 (UMAN)
\nSinoime: Nesiritide,Brain Natriuretic Peptide-32 uman,BNP-32, >98%;BNP-32 (uman) clorhidrat;Nesiritide [USAN:INN] ;SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (PUNTE DISULFUR\u0102: 10-26);SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER -SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS;H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY -ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH;H-SER-PRO-LYS -MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL -LEU-ARG-ARG-HIS-OH (PUNTE DISULFID\u0102: 10-26);PEPTID\u0102 NATRIURETIC\u0102 CEREBRAL\u0102 (1-32), UMAN
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nCategorii de produse:
\nFi\u0219ier Mol: 124584-08-3.mol<\/p>\n

Nesiritida a fost introdus\u0103 \u00een SUA ca un nou tratament intravenos pentru pacien\u021bii cu insuficienta cardiaca congestiva acut decompensata care prezinta dispnee in repaus sau cu activ minim ity. Nesiritida este prima form\u0103 uman\u0103 recombinat\u0103 a puternicei peptide natriuretice vasodilatatoare de tip B (cunoscut\u0103 \u0219i ca peptid\u0103 natriuretic\u0103 a creierului), o peptid\u0103 natural\u0103 de 32 de aminoacizi cu o structur\u0103 ineal\u0103 de 17 aminoacizi legat\u0103 de disulfur\u0103. Nesiritida se leag\u0103 de receptorul peptidei natriuretice Atip de pe suprafa\u021ba celulelor endoteliale \u0219i ale mu\u0219chilor netezi, stimul\u00e2nd producerea celui de-al doilea mesager cGMP, care mediaz\u0103 predominant relaxarea celulelor musculare netede vasculare. De asemenea, faciliteaz\u0103 eliminarea sodiului \u0219i a apei de c\u0103tre rinichi \u0219i scade secre\u021bia anumitor hormoni, cum ar fi adrenalina, angiotensina II, aldosteronul \u0219i endotelina, care provoac\u0103 efecte d\u0103un\u0103toare pe termen lung, inclusiv constric\u021bia vaselor de s\u00e2nge \u0219i cre\u0219terea tensiunii arteriale. \u00cen studiile clinice cu pacien\u021bi cu insuficien\u021b\u0103 cardiac\u0103, nesidtida a redus \u00een func\u021bie de doz\u0103 presiunea capilar\u0103 pulmonar\u0103, presiunea atrial\u0103 dreapt\u0103 \u0219i rezisten\u021ba vascular\u0103 sistemic\u0103 \u0219i a crescut indicele cardiac f\u0103r\u0103 a afecta ritmul cardiac. Efectul advers major observat a fost hipotensiunea dependent\u0103 de doz\u0103. \u00centr-un studiu comparativ de faz\u0103 III, nesiritida s-a dovedit a fi superioar\u0103 iv. nitroglicerina \u00een efectele ei hemodinamice precum \u0219i mai u\u0219or de administrat \u0219i mai bine tolerat. Nesiritida este eliminat\u0103 prin clivaj proteolitic de c\u0103tre enzima endopeptidaza neutr\u0103 NEP24.11 \u0219i prin legarea la receptorul peptidei natriuretice de tip C urmat\u0103 de endocitoz\u0103 \u0219i hidroliz\u0103 lizozomal\u0103 intracelular\u0103. Deoarece are un timp de \u00eenjum\u0103t\u0103\u021bire scurt (18 min), nesiritida se administreaz\u0103 ca perfuzie \u00een bolus de 21 \u03bcg\/kg urmat\u0103 de o perfuzie continu\u0103 de \u00eentre\u021binere la 0,011 \u03bcg\/kg\/min, de obicei, timp de 24-48 de ore.<\/p>\n

Nesiritida \/ BNP-32 (UMAN) CAS 124584-08-3 Propriet\u0103\u021bi chimice<\/strong>
\nBNP-32 (UMAN) Propriet\u0103\u021bi chimice
\ndensitate 1,52\u00b10,1 g\/cm3(Predic\u021bie)
\nRTECS EE1534000
\ntemp. \u221220\u00b0C
\nsub form\u0103 de pulbere
\nSolubilitate \u00een ap\u0103 Solubil \u00een ap\u0103 la 1mg\/ml
\nCAS DataBase Reference 124584-08-3<\/p>\n

Func\u021bia \u0219i aplicarea Nesiritidei \/ BNP-32 (UMAN) CAS 124584-08-3<\/strong>
\nTratamentul insuficien\u021bei cardiace congestive (antagonist al sistemului renin\u0103-angiotensin\u0103).<\/p>\n","protected":false},"excerpt":{"rendered":"

Nume produs: Nesiritide \/ BNP-32 (UMAN)
\nCAS: 124584-08-3
\nMF: C143H244N50O42S4
\nMW: 3464.04
\nEINECS: 1312995-182-4
\nCategorii de produse
\n &>Mol File: 124584-08-3.mol<\/p>\n","protected":false},"featured_media":2298,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[506],"product_tag":[1137],"class_list":{"0":"post-8577","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptida-sistemului-cardiovascular","7":"product_tag-nesiritide-bnp-32-human-cas-124584-08-3-brain-natriuretic-peptide-for-heart-failure-ro","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"shipping-taxable","15":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product\/8577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/comments?post=8577"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media\/2298"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media?parent=8577"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_brand?post=8577"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_cat?post=8577"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_tag?post=8577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}