{"id":8653,"date":"2021-12-17T01:51:53","date_gmt":"2021-12-17T06:51:53","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/glucagon-cas-16941-32-5-promoveaza-glicogenoliza-si-productia-de-glucoza-pentru-a-creste-glicemia\/"},"modified":"2021-12-17T01:51:53","modified_gmt":"2021-12-17T06:51:53","slug":"glucagon-cas-16941-32-5-promoveaza-glicogenoliza-si-productia-de-glucoza-pentru-a-creste-glicemia","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/ro\/product\/glucagon-cas-16941-32-5-promoveaza-glicogenoliza-si-productia-de-glucoza-pentru-a-creste-glicemia\/","title":{"rendered":"Glucagon CAS 16941-32-5 Promoveaz\u0103 glicogenoliza \u0219i produc\u021bia de glucoz\u0103 pentru a cre\u0219te glicemia"},"content":{"rendered":"<h2><strong>Glucagon CAS 16941-32-5 Promoveaz\u0103 glicogenoliza \u0219i produc\u021bia de glucoz\u0103 pentru a cre\u0219te glicemia<\/strong><\/h2>\n<p>Nume produs: Glucagon<br \/>\nSinome: GLUCAGON 1-37;GLUCAGON (1-37) (PORCIN);GLUCAGON 37;GLUCAGON ACETAT;HSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNKNNIA;H-HIS-SER-PHLY-GLN-PHLY-GLN-PHE -SER-ASP-TYR-SER-LYS-TYR-LEU-ASP-SER-ARG-ARG-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-LYS-ARG-ASN -LYS-ASN-ASN-ILE-ALA-OH;Glucagon 1-29;Glucagon(1-29) HCl uman<br \/>\nCAS: 16941-32-5<br \/>\nMF: C153H225N43O49S<br \/>\nMW: 3482,75&lt;&amp; &gt;EINECS: 685-611-6<br \/>\nCategorii de produse: Deriva\u021bi de aminoacizi;Peptide;Glucagon Biologia celulelor stem insulare;Diferen\u021bierea celulelor stem insulare;Hormoni;Al\u021bi hormoni proteici\/peptidici;Glucagon \u0219i peptide asem\u0103n\u0103toare glucagonuluiPeptide pentru biologia celular\u0103 Stemcagon Glucagon; Biologie celular\u0103; Factori de cre\u0219tere a citokinelor \u0219i hormoni (obezitate); Peptide gastrointestinale; GlucagonObesity Research; API; Diabetes Research<br \/>\nMol File: 16941-32-5.mol<\/p>\n<p>Glucagonul, cunoscut \u0219i sub numele de glucagon, este un hormon polipeptidic cu caten\u0103 liniar\u0103 secretat de celulele \u03b1 insulare pancreatice, care con\u021bine 29 de aminoacizi, cu formul\u0103 molecular\u0103 \u0219i relativ\u0103 molecular\u0103 masa C153H225N43O49S = 3482,8. China a sintetizat acest hormon. Este un fel de pulbere cristalin\u0103 fin\u0103 alb\u0103, inodor\u0103 \u0219i f\u0103r\u0103 gust, la temperatura camerei. Glucagonul este aproape insolubil \u00een ap\u0103 \u0219i \u00een majoritatea solven\u021bilor organici, \u00een timp ce este solubil \u00een acid diluat \u0219i solu\u021bie alcalin\u0103 diluat\u0103. Majoritatea preparatului sunt clorhidrat care se dizolv\u0103 \u00een ap\u0103. Se \u0219tie c\u0103 glucagonul trebuie s\u0103-\u0219i p\u0103streze integritatea molecular\u0103 pentru a-\u0219i exercita activitatea fiziologic\u0103. Structura glucagonului la om \u0219i la mamifer (iepurele, bovina, porcina, \u0219obolanul etc.) poate fi consistent\u0103, \u00een timp ce p\u0103s\u0103rile u\u0219or diferite.<\/p>\n<p>Glucagonul este o polipeptid\u0103 const\u00e2nd din 29 de aminoacizi \u0219i este secretat de celulele alfa. ale insulelor pancreasului. Glucagonul este produs din gena pro-glucagon, ini\u021bial ca precursor pro-glucagon, care este procesat specific \u021besuturilor \u00een celulele alfa pancreatice pentru a forma glucagon \u0219i \u00een celulele intestinale pentru a forma GLP-1 \u0219i GLP-2.<br \/>\n&lt;&amp; &gt;Este general acceptat ca insulina si glucagonul sunt principalii hormoni implicati in patofiziologia diabetului, dar rolul glucagonului in diabet este complex si controversat in unele cazuri. Rolul glucagonului \u00een agen\u021bii hipoglicemici utiliza\u021bi \u00een prezent prime\u0219te o aten\u021bie din ce \u00een ce mai mare, iar dezvoltarea continu\u0103 a terapiei \u021bintite cu glucagon eviden\u021biaz\u0103 contribu\u021bia important\u0103 a glucagonului \u00een optimizarea managementului diabetului.<\/p>\n<p>Glucagonul este un hormon contrareglator care stimuleaz\u0103 glucoza hepatic\u0103. produc\u021bie pentru a evita hipoglicemia. Receptorii de glucagon sunt localiza\u021bi pe hepatocite, iar locurile de legare a glucagonului au fost identificate \u0219i \u00een rinichi, inim\u0103, tractul gastrointestinal, \u021besutul adipos, creier \u0219i splin\u0103. Pe baza studiilor la c\u00e2ini, aproximativ 17% din glucagon este degradat de rinichi \u0219i 20% p\u00e2n\u0103 la 25% este degradat \u00een ficat. Eliberarea de glucagon ca r\u0103spuns la hipoglicemie a fost bine stabilit\u0103 \u0219i este mediat\u0103 prin mecanisme autonome, endocrine \u0219i paracrine \u0219i, posibil, de asemenea prin detectarea direct\u0103 a nivelului de glucoz\u0103 din s\u00e2nge de c\u0103tre celulele alfa. Mecanismele moleculare exacte prin care celulele secret\u0103 glucagon nu sunt pe deplin \u00een\u021belese, dar implic\u0103 canalele de adenozin trifosfat de potasiu (KATP) \u0219i canalele de calciu. zinc \u0219i acid gamma-aminobutiric (GABA), care sunt eliberate ca r\u0103spuns la mese \u0219i la cre\u0219terea glicemiei. C\u00e2nd nivelurile de glucoz\u0103 din s\u00e2nge scad, celulele beta reduc produc\u021bia acestor produse, elimin\u00e2nd astfel efectul lor inhibitor asupra celulelor alfa. Acest mecanism, cunoscut sub numele de ipoteza \u201e\u00eenchiderii\u201d, duce \u00een cele din urm\u0103 la o cre\u0219tere a secre\u021biei de glucagon atunci c\u00e2nd glicemia este prea sc\u0103zut\u0103. Hormonul inhibitor de cre\u0219tere, care este produs de celulele \u03b4 \u0219i GLP-1 \u00een insuli\u021be, inhib\u0103, de asemenea, secre\u021bia de glucagon.<\/p>\n<p>At\u00e2t \u00een diabetul zaharat de tip 1 (T1DM) c\u00e2t \u0219i \u00een diabetul zaharat de tip 2 (T2DM), nivelurile plasmatice de glucagon sunt prea \u00eenalte. Glucagonul, un hormon de reglare care promoveaz\u0103 produc\u021bia hepatic\u0103 de glucoz\u0103, previne hipoglicemia \u00een condi\u021bii fiziologice normale. La pacien\u021bii cu diabet, secre\u021bia de glucagon poate fi necontrolat\u0103, ceea ce duce la probleme cu homeostazia glucozei. Unele tratamente pentru diabet sunt eficiente prin inhibarea secre\u021biei sau ac\u021biunii glucagonului, precum \u0219i prin terapia \u021bintit\u0103 specific\u0103 glucagonului.<\/p>\n<p> <strong>Glucagon CAS 16941-32-5 Propriet\u0103\u021bi chimice<\/strong><br \/>\ndensitate 1,53\u00b10,1 g\/cm3( Prev\u0103zut\u0103)<br \/>\ntemp. A se p\u0103stra la loc \u00eentunecat, Sigilat \u00een uscat, 2-8\u00b0C<br \/>\nsolubilitate Practic insolubil \u00een ap\u0103 \u0219i \u00een majoritatea solven\u021bilor organici. Este solubil \u00een acizi minerali dilua\u021bi \u0219i \u00een solu\u021bii diluate de hidroxizi alcalini.<br \/>\nform\u0103 pulbere<\/p>\n<p> <strong>Func\u021bia \u0219i aplicarea glucagonului CAS 16941-32-5<\/strong><br \/>\n1\u3001Cre\u0219te efectul glucozei din s\u00e2nge: poate activa fosforilaza hepatic\u0103, promoveaz\u0103 descompunerea glicogenului hepatic \u0219i izogenizarea glicogenului \u0219i cre\u0219te glicemia.<br \/>\n2, Efect inotrop pozitiv: poate cre\u0219te con\u021binutul de cAMP intracelular, poate cre\u0219te contractilitatea miocardic\u0103, poate cre\u0219te debitul cardiac \u0219i poate func\u021biona pe b\u0103taie. Efectul s\u0103u inotrop pozitiv poate fi \u00eenc\u0103 exercitat dup\u0103 aplicarea unei cantit\u0103\u021bi suficiente de glicozid\u0103 cardiac\u0103 \u0219i nu este blocat de propranolol. De\u0219i poate cre\u0219te ritmul cardiac \u0219i tensiunea arterial\u0103, nu provoac\u0103 aritmie. Mecanismele sunt: (1) activarea adenilat ciclazei pentru a converti adenozin trifosfat \u00een adenozin monofosfat ciclizat, ceea ce cre\u0219te contractilitatea miocardic\u0103; (2) promovarea glicogenolizei hepatice \u0219i cre\u0219terea nivelului de glucoz\u0103 din s\u00e2nge; (3) promovarea eliber\u0103rii de insulin\u0103 eliberarea Chemicalbook, \u00eembun\u0103t\u0103\u021birea utiliz\u0103rii miocardice a glucozei \u0219i promovarea enzimelor anaerobe miocardice, \u00eembun\u0103t\u0103\u021bind astfel metabolismul energetic miocardic. Combinat cu glicozide cardiace asem\u0103n\u0103toare digitalicelor, poate cre\u0219te eficacitatea.<br \/>\n3. Efecte asupra rinichilor: dilat\u0103 vasele de s\u00e2nge renale, \u00eembun\u0103t\u0103\u021be\u0219te fluxul sanguin renal \u0219i promoveaz\u0103 excre\u021bia de sodiu, potasiu \u0219i calciu.<br \/>\n4. Efecte asupra sistemului digestiv: poate provoca relaxarea mu\u0219chilor netezi ai stomacului \u0219i duodenului, intestinului sub\u021bire \u0219i colonului, inhib\u0103 peristaltismul stomacului, intestinului sub\u021bire \u0219i colonului \u0219i cre\u0219te secre\u021bia de bil\u0103 \u0219i lichid intestinal.<br \/>\n5. Efecte asupra sistemului secretor: excita medula suprarenal\u0103, promoveaz\u0103 eliberarea de catecolamine. De asemenea, poate promova secre\u021bia de insulin\u0103, hormon tiroidian, calcitonin\u0103 \u0219i hormon de cre\u0219tere.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nume produs: Glucagon<br \/>\nCAS: 16941-32-5<br \/>\nMF: C153H225N43O49S<br \/>\nMW: 3482,75<br \/>\nEINECS: 685-611-6<br \/>\nMol File: 16941-32-5.mol<\/p>\n","protected":false},"featured_media":2130,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[],"product_tag":[1103],"class_list":{"0":"post-8653","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_tag-glucagon-cas-16941-32-5-promotes-glycogenolysis-and-glucose-production-to-raise-blood-sugar-ro","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product\/8653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/comments?post=8653"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media\/2130"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media?parent=8653"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_brand?post=8653"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_cat?post=8653"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_tag?post=8653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}