{"id":8782,"date":"2021-12-17T03:06:08","date_gmt":"2021-12-17T08:06:08","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/acetat-de-goserelina-de-inalta-calitate-cas-145781-92-6-folosit-pentru-tratarea-cancerului-de-san\/"},"modified":"2021-12-17T03:06:08","modified_gmt":"2021-12-17T08:06:08","slug":"acetat-de-goserelina-de-inalta-calitate-cas-145781-92-6-folosit-pentru-tratarea-cancerului-de-san","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/ro\/product\/acetat-de-goserelina-de-inalta-calitate-cas-145781-92-6-folosit-pentru-tratarea-cancerului-de-san\/","title":{"rendered":"Acetat de goserelin\u0103 de \u00eenalt\u0103 calitate CAS 145781-92-6 folosit pentru tratarea cancerului de s\u00e2n"},"content":{"rendered":"

Acetat de goserelin\u0103 de \u00eenalt\u0103 calitate CAS 145781-92-6 folosit pentru tratarea cancerului de s\u00e2n<\/strong><\/h2>\n

Nume produs: acetat de goserelin\u0103
\nSinome: PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2;[(T-BU)DSER6, (AZA) )GLY10]-LH-RH;[(T-BU)DSER6, (AZA)GLY10]-HORMON DE ELIBERARE A HORMONULUI LUTEINIZANT; ICI-118630 acetat; GOSERELIN HCL[PYR-HIS-TRP-SER-TYR-D-SER( T-BU)-LEU-ARG-PRO-AZAGLY-NH2];Factor de eliberare a hormonului 1-9-luteinizant (porcin), 6-(o-(1,1-dimetiletil)-D-serin\u0103)-, 2- (aminocarbonil)hidrazid\u0103, acetat (sare);Fertilan;GLP-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZA-GLY-NH2
\nCAS: 145781-92-6
\nMF: C59H84N18O14
\nMW: 1269,41
\nEINECS: 652-995-1
\nCategorii de produse: Peptide;Pepetide;Deriva\u021bi de aminoacizi;Intermediari \u0219i produse chimice fine;Peptide;Fi\u0219iere farmaceutice
\n 145781-92-6.mol<\/p>\n

Acetatul de goserelin\u0103, ca \u0219i acetatul de leuprolid\u0103, este un analog nonapeptidic superagonist sintetic al GnRH care posed\u0103 o poten\u021b\u0103 mai mare dec\u00e2t hormonul natural. Re\u021bine\u021bi c\u0103 con\u021bine D-Ser(But) \u0219i NH-NHCONH2 \u00een loc de Gly6 \u0219i, respectiv, Gly10-NH2. Adic\u0103, modificarea C-terminal\u0103 are pur \u0219i simplu un NH care \u00eenlocuie\u0219te CH2 al Gly \u0219i, ca \u0219i modificarea C-terminal\u0103 a acetatului de leuprolid\u0103, aceasta inhib\u0103 degradarea enzimatic\u0103 a peptidei de c\u0103tre peptidaza postprolin\u0103 carboxiamid\u0103.
\nGoserelin acetat este disponibil \u00een forma unei granule mici, solide, care se administreaz\u0103 ca implant SC pentru tratamentul paliativ al cancerului de s\u00e2n avansat, metastatic, la femeile \u00een pre- \u0219i perimenopauz\u0103 sau, \u00een mod similar, ca paliativ \u00een cancerul de prostat\u0103 avansat. Motivul pentru utilizarea acestui medicament este, a\u0219a cum este descris mai sus, capacitatea sa ca superagonist de a aduce nivelurile de estradiol sau testosteron aproape de nivelurile de castrare, \u00eencetinind astfel progresia carcinomului de s\u00e2n sau, respectiv, de prostat\u0103. \u00cen plus, acetatul de goserelin\u0103 este aprobat pentru utilizare \u00een tratarea endometriozei timp de p\u00e2n\u0103 la 6 luni.<\/p>\n

Acetat de goserelin\u0103 CAS 145781-92-6 Propriet\u0103\u021bi chimice<\/strong>
\nPunctul de topire >190\u00b0C (dec.)
\ndepozitare temp. -20\u00b0C
\nsolubilitate H2O: 20 mg\/mL, limpede, incolor
\nform\u0103 pulbere alb\u0103
\nInChIKey IKDXDQDKCZPQSZ-JHYYTBFNSA-N
\nCAS DataBase Reference 145781-92-6<\/p>\n

Func\u021bie \u0219i aplicare Goserelin acetat CAS 145781-92-6<\/strong>
\n1. Anticancer
\n2. Supragonist al hormonului de eliberare a gonadotropinei injectabil (agonist GnRH) sau activitate antiproliferativ\u0103 a hormonului luteinizant \u00een cancerele de s\u00e2n, prostat\u0103 \u0219i endometrie
\n3. Agonist peptidic sintetic analog al LH-RH. Antineoplazice (hormonale).<\/p>\n","protected":false},"excerpt":{"rendered":"

Nume produs: Goserelin acetat
\nCAS: 145781-92-6
\nMF: C59H84N18O14
\nMW: 1269,41
\nEINECS: 652-995-1
\nMol File: 145781-92-6.mol<\/p>\n","protected":false},"featured_media":2214,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[],"product_tag":[968],"class_list":{"0":"post-8782","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_tag-goserelin-acetate-cas-145781-92-6-used-for-treat-breast-cancer-ro","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product\/8782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/comments?post=8782"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media\/2214"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/media?parent=8782"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_brand?post=8782"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_cat?post=8782"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/ro\/wp-json\/wp\/v2\/product_tag?post=8782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}