{"id":7288,"date":"2021-12-16T07:20:55","date_gmt":"2021-12-16T12:20:55","guid":{"rendered":"https:\/\/puyapeptide.net\/product\/enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv\/"},"modified":"2021-12-16T07:20:55","modified_gmt":"2021-12-16T12:20:55","slug":"enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv","status":"publish","type":"product","link":"https:\/\/puyapeptide.net\/sv\/product\/enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv\/","title":{"rendered":"Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 f\u00f6r anti-HIV"},"content":{"rendered":"

Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 f\u00f6r anti-HIV<\/strong><\/h2>\n

Produktnamn: Enfuvirtide
\nSekvens: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys< &>-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
\nSynonymer: Enfuvirtide; T-2;Enfuvirtidacetat (T-20);ENFUVIRTIDE(T-20) 98+%;Enfurvitide(T-20);Pentafusid;Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile -Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn -Trp-Phe-NH{2};Enfuvirtide;Aids059486
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-&>385-0 Produktkategorier< : proteiner;Peptid
\nMol Fil: 159519-65-0.mol<\/p>\n

Det \u00e4r en syntetisk peptidh\u00e4mmare av HIV-fusion, som kan binda till det virala h\u00f6ljesglykoproteinet och f\u00f6rhindra de konformationsf\u00f6r\u00e4ndringar som \u00e4r n\u00f6dv\u00e4ndiga f\u00f6r viruset att sm\u00e4lta samman med cellmembranet, och p\u00e5 s\u00e5 s\u00e4tt h\u00e4mma replikationen av HIV-1. Enfevir-peptiden h\u00e4rr\u00f6r fr\u00e5n en naturligt f\u00f6rekommande aminosyrasekvens i HR2-dom\u00e4nen av gp41. Genom att simulera aktiviteten hos HR2-dom\u00e4nen och kompetitivt binda till HR1-dom\u00e4nen av gp41, f\u00f6rhindrar Enfevir-peptiden interaktionen mellan HR1 och HR2 och f\u00f6r\u00e4ndringar i konfigurationen av Gp41, vilket f\u00f6rhindrar fusionen av viruset med v\u00e4rdceller.<\/p>\n

Enfuvirtide \u00e4r den f\u00f6rsta i en ny klass av HIV-l\u00e4kemedel som interfererar med intr\u00e4det av HIV-1 genom att h\u00e4mma sammansm\u00e4ltning av virala och cellul\u00e4ra membran. Det binder till den f\u00f6rsta heptad-upprepningen (HR1) i ghe gp41-subenheten av det virala h\u00f6ljesglykoproteinet och f\u00f6rhindrar de konformationsf\u00f6r\u00e4ndringar som kr\u00e4vs f\u00f6r fusionen med cellmembran, vilket representerar en ny mekanism. Det \u00e4r en potent h\u00e4mmare av denna bindning med en IC50 i laboratorie- och prim\u00e4risolat (HIV-1 clades A\u2013G) som str\u00e4cker sig fr\u00e5n 4 till 280 nM (18\u20131260 ng\/mL), men har praktiskt taget ingen aktivitet mot HIV-2. P\u00e5 grund av sin unika mekanism visar den inte korsresistens mot NRTI, NNRTI och PI. Den framst\u00e4lls genom kemisk syntes, med en kombination av l\u00f6snings- och fastfassteg. Fastfasstegen anv\u00e4nder fmoc-skydd och det syrak\u00e4nsliga 2-klorotritylkloridhartset f\u00f6r att producera peptider med l\u00e4ngder fr\u00e5n nio till sexton aminosyror. <\/p>\n

Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0 Kemiska egenskaper<\/strong>
\nlagringstemp. -20\u00b0C
\nform pulver
\nf\u00e4rg vit till benvit<\/p>\n

Anv\u00e4ndning av Enfuvirtide\/ Enfuvirtide Acetate CAS 159519-65-0<\/strong>
\nDet anv\u00e4nds i kombination med l\u00e4kemedel f\u00f6r omv\u00e4nt transkriptas f\u00f6r m\u00e4nniskor infektion med immunbristvirus (HIV).<\/p>\n","protected":false},"excerpt":{"rendered":"

Produktnamn: Enfuvirtide
\nCAS: 159519-65-0
\nMF: C204H301N51O64
\nMW: 4491.92
\nEINECS: 641-385-0
\nMol Fil: 159519-65-0.mol.<\/p>\n","protected":false},"featured_media":2133,"comment_status":"open","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[],"product_tag":[2513],"class_list":{"0":"post-7288","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_tag-enfuvirtide-enfuvirtide-acetate-cas-159519-65-0-for-anti-hiv-sv","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product\/7288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/comments?post=7288"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/media\/2133"}],"wp:attachment":[{"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/media?parent=7288"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_brand?post=7288"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_cat?post=7288"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/puyapeptide.net\/sv\/wp-json\/wp\/v2\/product_tag?post=7288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}